Active Site

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Name: Active Site
First reported Aug 21 2014 - Updated Aug 21 2014 - 1 reports

Dublin Road stretch north of Glick reopens

A stretch of Dublin Road north of Glick Road was reopened Thursday, Aug. 21, a day ahead of schedule.The road was closed starting Aug. 11 as construction on left-turn lanes for the Dublin-Glick intersection began.Although roads will remain open during ... [Published This Week Dublin - Aug 21 2014]
First reported Aug 19 2014 - Updated Aug 19 2014 - 1 reports

Antimicrobial Peptide Resistance of Vibrio cholerae Results from an LPS Modification Pathway Related to Nonribosomal Peptide Synthetases

The current pandemic El Tor biotype of O1 Vibrio cholerae is resistant to polymyxins, whereas the previous pandemic strain of the classical biotype is polymyxin sensitive. The almEFG operon found in El Tor V. cholerae confers >100-fold resistance to ... [Published ACS Chemical Biology - Aug 19 2014]
Entities: El Tor, Peptide, Protein
First reported Aug 15 2014 - Updated Aug 15 2014 - 1 reports

Insights into the mechanistic details of protein synthesis could inform efforts to manipulate the genetic code

In the naturally occurring guanine–uracil ‘identity set’ pairing (top), the tRNA acceptor region (yellow) is properly positioned at the enzyme’s active site for chemical modification with the amino acid alanine. In the adenine–uracil mutant (bottom), ... [Published PhysOrg.com - Aug 15 2014]
First reported Aug 15 2014 - Updated Aug 15 2014 - 1 reports

A candidate for HER2

NEW YORK—DepYmed Inc., a joint venture of and , announced recently the validation of Trodusquemine as a therapeutic candidate for HER2-positive breast cancer. The results were published online May 20 in . Trodusquemine (or MSI-1436) is the company’s inhibitor ... [Published Drug Discovery News - Aug 15 2014]
First reported Aug 14 2014 - Updated Aug 14 2014 - 1 reports

MnO2 spontaneously coated on carbon nanotubes for enhanced water oxidation

δ-MnO2/o-MWCNTs were synthesised by simple immersion of the o-MWCNTs into a KMnO4 solution. This catalyst possesses high catalytic activity as well as durability in photocatalytic water oxidation with Na2S2O8 and [Ru(bpy)3]2+. A series of control experiments ... [Published RSC - Aug 14 2014]
First reported Aug 13 2014 - Updated Aug 13 2014 - 1 reports

Redesigning Human 2′-Deoxycytidine Kinase Enantioselectivity for l-Nucleoside Analogues as Reporters in Positron Emission Tomography

Recent advances in nuclear medicine have allowed for positron emission tomography (PET) to track transgenes in cell-based therapies using PET reporter gene/probe pairs. A promising example for such reporter gene/probe pairs are engineered nucleoside kinases ... [Published ACS Chemical Biology - Aug 13 2014]
First reported Aug 13 2014 - Updated Aug 13 2014 - 1 reports

Cryo-EM enters a new era

Related research article Scheres SHW. 2014. Beam-induced motion correction for sub-megadalton cryo-EM particles. eLife 3 :e03665. doi: 10.7554/eLife.03665Image Electron micrograph of showing particles of the enzyme γ-secretaseThe development of new detector ... [Published Elifesciences - Aug 13 2014]
First reported Aug 13 2014 - Updated Aug 13 2014 - 1 reports

Enhancing treatment options for schizophrenia

Expanding the options for treating central nervous system disorders such as schizophrenia has emerged with a new approach and a potential new class of drug.The research, conducted by Dr Rob Lane and colleagues from the  Monash Institute for Pharmaceutical ... [Published Australian Life Scientist - Aug 13 2014]
First reported Aug 12 2014 - Updated Aug 12 2014 - 1 reports

9 Ways To Become Content Marketing King

Why is it that most small businesses are ignorant about content marketing? The few businesses that try it usually fail at it. Why? Content marketing seems simple. Write some stuff; sit back and relax. Unfortunately, most of the “content” is useless. As ... [Published Business 2 Community - Aug 12 2014]
First reported Aug 12 2014 - Updated Aug 12 2014 - 1 reports

'Enzyme-Search Engine' Reveals Hidden Possibilities of Nature

A new search engine, including a database with more than 100.000 proteins, opens up new possibilities in the search for industrial usable enzymes or for alternatives to patented biocatalysts. The method was published in Nature Communications.GRAZ, AUSTRIA, ... [Published Pettinga Financial Advisors - Aug 12 2014]
First reported Aug 05 2014 - Updated Aug 05 2014 - 1 reports

A Multiscale Approach to Modelling Drug Metabolism by Membrane-Bound Cytochrome P450 Enzymes

by Richard Lonsdale, Sarah L. Rouse, Mark S. P. Sansom, Adrian J. MulhollandCytochrome P450 enzymes are found in all life forms. P450s play an important role in drug metabolism, and have potential uses as biocatalysts. Human P450s are membrane-bound proteins. ... [Published Plosone.org - Aug 05 2014]
First reported Aug 04 2014 - Updated Aug 04 2014 - 1 reports

Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

by Carl I. Webster, Matthew Burrell, Lise-Lotte Olsson, Susan B. Fowler, Sarah Digby, Alan Sandercock, Arjan Snijder, Jan Tebbe, Ulrich Haupts, Joanna Grudzinska, Lutz Jermutus, Christin AnderssonNeprilysin is a transmembrane zinc metallopeptidase that ... [Published Plosone.org - Aug 04 2014]

Quotes

..."It was a complete mystery how these nucleotides indirectly affect the active site of the enzyme," says Yokoyama. "Furthermore, it seemed almost impossible that a tRNA could depend so strictly on a single base-pair interaction."
"In this regard we will have an active site office at Lucky Bay"
"Nevertheless, while this disclosure preferably comprises nanoceria compositions and treatments directed to eye conditions and, particularly, to glaucoma, the invention includes within its scope the concept of associating a drug with the nanoceria particles as carriers. The range of drugs that can be employed in the invention is rather broad and includes any drug or pharmaceutical composition that can be complexed, associated with or otherwise bound to the nanoceria particles without significantly adversely affecting the biological activity of the drug."
The "Catalophor System" has a high practical benefit for science and industry. "Based on the protein structures we can discover new possible reaction pathways of enzymes that have not been described yet. For the chemical industry our approach opens up new reaction pathways that were not possible until now" says Prof. K Gruber...

More Content

All (92) | News (80) | Reports (0) | Blogs (10) | Audio/Video (0) | Fact Sheets (1) | Press Releases (1)
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Dublin Road stretch north of Glick reopens [Published This Week Dublin - Aug 21 2014]
The Cytoplasmic Capping Complex Assembles on Ad... [Published PLoS Biology - Aug 19 2014]
Antimicrobial Peptide Resistance of Vibrio cho... [Published ACS Chemical Biology - Aug 19 2014]
Ibrutinib in Previously Treated CLL and CLL Wit... [Published The ASCO Post - Aug 15 2014]
Insights into the mechanistic details of protei... [Published PhysOrg.com - Aug 15 2014]
A candidate for HER2 [Published Drug Discovery News - Aug 15 2014]
Lucky Bay-Wallaroo ferry to stop [Published Murray Valley Standard - Aug 15 2014]
MnO2 spontaneously coated on carbon nanotubes f... [Published RSC - Aug 14 2014]
Patent Issued for Functionalized Nanoceria Comp... [Published HispanicBusiness.com - Aug 14 2014]
Highly Available Hybrid [Published Linux Developer's Journal - Aug 13 2014]
Redesigning Human 2′-Deoxycytidine Kinase Enant... [Published ACS Chemical Biology - Aug 13 2014]
Cryo-EM enters a new era [Published Elifesciences - Aug 13 2014]
Enhancing treatment options for schizophrenia [Published Australian Life Scientist - Aug 13 2014]
9 Ways To Become Content Marketing King [Published Business 2 Community - Aug 12 2014]
The dUTPase-related gene of bovine immunodefici... [Published 7thSpace - Aug 12 2014]
'Enzyme-Search Engine' Reveals Hidden Possibili... [Published Pettinga Financial Advisors - Aug 12 2014]
PLS in CcO [Biophysics and Computational Biology] [Published PNAS - Aug 12 2014]
Structure of the VipD-Rab5 complex [Biophysics ... [Published PNAS - Aug 12 2014]
Crystal Structures of PRK1 in Complex with the ... [Published Plosone.org - Aug 12 2014]
Crystal Structure Confirmation of JHP933 as a N... [Published Plosone.org - Aug 07 2014]
Findings from Council of Scientific and Industr... [Published HispanicBusiness.com - Aug 07 2014]
Findings from National Institutes of Health Bro... [Published HispanicBusiness.com - Aug 07 2014]
Systems Pharmacology Dissection of Multi-Scale ... [Published Plosone.org - Aug 06 2014]
Diverse Functionalization of Aurora-A Kinase at... [Published Plosone.org - Aug 06 2014]
Characterization of a Novel BCHE “Silent” Allel... [Published Plosone.org - Aug 06 2014]
Inhibitor of the Tyrosine Phosphatase STEP Reve... [Published PLoS Biology - Aug 06 2014]
A Multiscale Approach to Modelling Drug Metabol... [Published Plosone.org - Aug 05 2014]
Structure of a Membrane-Embedded Prenyltransfer... [Published Plosone.org - Aug 05 2014]
HIV protease dimerization occurs through two st... [Published PNAS - Aug 05 2014]
Meet the 'Lego Death Star' Designed to Kill Can... [Published Motherboard Magazine - Aug 04 2014]
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Blogs

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New catalytic system for conversion of CO2 to m... [Published Green Car Congress - Aug 01 2014]
Scanning tunneling microscope image of a cerium-oxide and copper catalyst (CeOx-Cu) used in the transformation of CO2 and H2 to methanol (CH3OH) and water. In the presence of hydrogen, the Ce4+ and Cu1+ are reduced to Ce3+ and Cu0 with a change in ...
Altered Microbial Enzyme Eats Up Cocaine, Could... [Published Popular Science - New Technology, Science News, ... - Jun 24 2014]
A Pile Of Cocainevia STV Glasgow Bacteria that live in the soil near coca plants make an enzyme called cocaine esterase , which rapidly breaks down the drug. The enzyme could theoretically be useful to  destroy cocaine ingested by people before ...
Covalent Fragments [Published In the Pipeline - May 30 2014]
Many drug discovery researchers now have an idea of what to expect when a fragment library is screened against a new target. And some have had the experience of screening covalent, irreversible inhibitor structures against targets (a hot topic in recent ...
Successful Test of Solve H2O™ Treatment System ... [Published EnviroLib - May 20 2014]
Las Vegas,NV (PRWEB) May 20, 2014 Acqua Innovations, Inc. today announced the results of a successful bench scale test of the company’s pilot Solve H2O™ Treatment System to remove 1,4-dioxane from groundwater extracted from an active site. 1,4-dioxane ...
In Culture News: Lynn Shelton Films a Pilot, Th... [Published The Stranger, Seattle's Only Newspaper - May 15 2014]
Schmeater Schnannouncement: Almost exactly a year ago, Theater Schmeater got kicked out of its basement home on Capitol Hill , where it had produced scrappy basement performances—sometimes deadly serious, sometimes terminally goofy—for 21 years. On ...
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Press Releases

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Successful Test of Solve H2O(TM) Treatment Syst... [Published GlobeNewswire: Acquisitions News - May 20 2014]
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