Active Site

Type: Keyphrase
Name: Active Site
First reported 16 hours ago - Updated 16 hours ago - 1 reports

Depsipeptides and their therapeutic use

A compound of the general Structure (VII) or (VIII) including isoteres and pharmaceutically acceptable salts thereof, wherein R1, R2 (where X=—CONR6—), R3 and R7 are the same or different and each represents an amino-acid side chain moiety; R2 (where ... [Published Free Patents Online - 16 hours ago]
Entities: Moiety, In Vivo, Carbon
First reported Oct 18 2014 - Updated Oct 18 2014 - 1 reports

Understanding the Mechanism of Atovaquone Drug Resistance in Plasmodium falciparum Cytochrome b Mutation Y268S Using Computational Methods

by Bashir A. Akhoon, Krishna P. Singh, Megha Varshney, Shishir K. Gupta, Yogeshwar Shukla, Shailendra K. GuptaThe rapid appearance of resistant malarial parasites after introduction of atovaquone (ATQ) drug has prompted the search for new drugs as even ... [Published - Oct 18 2014]
First reported Oct 17 2014 - Updated Oct 17 2014 - 1 reports

Active site engineering in UiO-66 type metal-organic frameworks by intentional creation of defects: a theoretical rationalization

The catalytic activity of the Zr-benzenedicarboxylate (Zr-BDC) UiO-66 can be drastically increased if some BDC linkers are missing, as this removes the full coordination of the framework metal ions. As a result, metal centers become more accessible and ... [Published RSC - Oct 17 2014]
First reported Oct 16 2014 - Updated Oct 16 2014 - 1 reports

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures

IntroductionCleavage of transmembrane domains (TMDs) by intramembrane proteases has emerged as an important and evolutionarily widespread signalling and quality control mechanism with medical significance (Brown et al , 2000 ; Lemberg, 2011 ), but a full ... [Published EMBO Journal - Oct 16 2014]
First reported Oct 13 2014 - Updated Oct 13 2014 - 1 reports

How bacteria evolve defenses to antibiotics

High-resolution cryo-electron microscopy has now revealed in unprecedented detail the structural changes in the bacterial ribosome which results in resistance to the antibiotic erythromycin.Multiresistant bacterial pathogens that are insensitive to virtually ... [Published - Oct 13 2014]
First reported Oct 10 2014 - Updated Oct 10 2014 - 1 reports

Dual Effects of Alpha-Arbutin on Monophenolase and Diphenolase Activities of Mushroom Tyrosinase

by Liang Qin, Yang Wu, Youting Liu, Yiming Chen, Peng ZhangThe effects of α-arbutin on the monophenolase and diphenolase activities of mushroom tyrosinase were investigated. The results showed that α-arbutin inhibited monophenolase activity but it activated ... [Published - Oct 10 2014]
First reported Oct 07 2014 - Updated Oct 07 2014 - 1 reports

Unique properties of cbb3 H+ channel [Biophysics and Computational Biology]

Young O. Ahn a , Paween Mahinthichaichan a , Hyun Ju Lee b , Hanlin Ouyang a , Daniel Kaluka c , Syun-Ru Yeh c , Davinia Arjona b , Denis L. Rousseau c , Emad Tajkhorshid a , Pia Ädelroth b , and Robert B. Gennis a , 1 a Department of Biochemistry, ... [Published PNAS - Oct 07 2014]
First reported Oct 07 2014 - Updated Oct 07 2014 - 1 reports

Structure and regulation of the plant CIPKs [Plant Biology]

Antonio Chaves-Sanjuan a , Maria Jose Sanchez-Barrena a , Juana Maria Gonzalez-Rubio a , Maria Moreno a , Paula Ragel b , Marta Jimenez a , Jose M. Pardo b , Martin Martinez-Ripoll a , Francisco J. Quintero b , and Armando Albert a , 1 a Departamento ... [Published PNAS - Oct 07 2014]
Entities: Kinase, Active Site, Ion
First reported Sep 30 2014 - Updated Sep 30 2014 - 1 reports

Neuronal pain pathway modulators

The present invention relates to compounds that may be used to inhibit activation of protein kinase G (“PKG”). It is based, at least in part, on the discovery of the tertiary structure of PKG and the identification of molecules that either bind to the ... [Published Free Patents Online - Sep 30 2014]
First reported Sep 29 2014 - Updated Sep 29 2014 - 1 reports

Multi-Mode Binding of Cellobiohydrolase Cel7A from Trichoderma reesei to Cellulose

by Jürgen Jalak, Priit VäljamäeEnzymatic hydrolysis of recalcitrant polysaccharides like cellulose takes place on the solid-liquid interface. Therefore the adsorption of enzymes to the solid surface is a pre-requisite for catalysis. Here we used enzymatic ... [Published - Sep 29 2014]
First reported Sep 29 2014 - Updated Sep 29 2014 - 2 reports

Unlocking Enzyme Synthesis of Rare Sugars to Create Drugs with Fewer Side Effects

Contact InformationAvailable for logged-in reporters onlyNewswise — A team led by the U.S. Department of Energy's Oak Ridge National Laboratory has unlocked the enzymatic synthesis process of rare sugars, which are useful in developing drugs with low ... [Published Newswise - Sep 29 2014]
Entities: Enzyme, Neutron, Sugar
First reported Sep 22 2014 - Updated Sep 22 2014 - 1 reports

The Selective Interaction between Silica Nanoparticles and Enzymes from Molecular Dynamics Simulations

IntroductionNanoscale particles have become promising materials in many fields, such as cancer therapeutics, diagnosis, imaging, drug delivery, catalysis, as well as biosensors. However, very little is known about exactly how a protein interacts with ... [Published - Sep 22 2014]
Entities: Rnase, Active Site, Enzyme


According to the news editors, the research concluded: "A similar orientation of the superoxide ligand in the putative Fe(III)-superoxo reaction intermediate would promote the attack of the distal oxygen atom on the sulfur of substrate Cys."
...insights into the ultrastructural changes in an intracellular machine associated with the acquisition of resistance to the antibiotic erythromycin. "A better understanding of this mechanism is an important step towards the development of new and more potent antibiotics" Wilson says
"It's very difficult. These decisions to actually downsize and to make sure that each mine stays competitive, because if a mine's not competitive, then job security is not present."
More information: Gwang Hyeon Gwon et al, "Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates" EMBO J 33 (9), 937 (2014). DOI: 10.1002/embj.201487820

More Content

All (98) | News (87) | Reports (0) | Blogs (9) | Audio/Video (0) | Fact Sheets (1) | Press Releases (1)
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Depsipeptides and their therapeutic use [Published Free Patents Online - 16 hours ago]
Bacterial defense policies [Published Health Canal - Oct 21 2014]
Low Dose Protease Inhibitor Discovery for HIV-AIDS [Published Medianet - Oct 18 2014]
Understanding the Mechanism of Atovaquone Drug ... [Published - Oct 18 2014]
Inhibition of Human Aldehyde Oxidase Activity b... [Published Drug Metabolism And Disposition - Oct 17 2014]
Active site engineering in UiO-66 type metal-or... [Published RSC - Oct 17 2014]
New WSU palladium-iron catalyst could improve d... [Published Green Car Congress - Oct 17 2014]
New WSU palladium-iron catalyst could improve d... [Published Green Car Congress - Oct 17 2014]
The evolution of metazoan α-carbonic anhydrase... [Published 7thSpace - Oct 17 2014]
The severity of irritable bowel syndrome or the... [Published 7thSpace - Oct 17 2014]
The severity of irritable bowel syndrome or the... [Published BMC - Oct 17 2014]
Review of Selected NMEs 2014 [Published U.S.Pharmacist - Oct 16 2014]
How Cloud has Changed Data Center Technology [Published Data Center Knowledge - Oct 16 2014]
Highly Efficient and Enzymatic Regioselective U... [Published - Oct 16 2014]
Dynamic architecture of a protein kinase [Bioph... [Published PNAS - Oct 16 2014]
DNA end recognition by the Mre11 nuclease dimer... [Published EMBO Journal - Oct 16 2014]
Substrate binding and specificity of rhomboid i... [Published EMBO Journal - Oct 16 2014]
Studies from University of Wisconsin Yield New ... [Published 4 Traders - Oct 16 2014]
Is There a 4G Problem? [Published Radio World Newspaper - Oct 15 2014]
Tracking metal ions through a Cu/Ag efflux pump... [Published PNAS - Oct 14 2014]
How bacteria evolve defenses to antibiotics [Published - Oct 13 2014]
Coal good for humanity, says Abbott [Published Northern Territory News - Oct 13 2014]
South Pacific cruise visits Indonesian islands [Published Redlands Daily Facts - Oct 12 2014]
Novel Nucleophiles Enhance the Human Serum Para... [Published Toxicological Sciences - Oct 11 2014]
The SH2 Domain Regulates c-Abl Kinase Activatio... [Published - Oct 11 2014]
Dual Effects of Alpha-Arbutin on Monophenolase ... [Published - Oct 10 2014]
Enhancement of Synthetic Trichoderma-Based Enzy... [Published - Oct 08 2014]
How to remove tangles in your DNA [Published - Oct 08 2014]
Engineering the elongation factor Tu for effici... [Published - Oct 08 2014]
Plans advance in Evesham to develop vacant plaza [Published - Oct 08 2014]
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In Focus
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New WSU palladium-iron catalyst could improve d... [Published Green Car Congress - Oct 17 2014]
The addition of palladium (Pd) prevents deactivation (addition of oxygen, red spheres) of an iron catalyst in the reaction that removes oxygen from biofuel feedstock. Credit: ACS, Hensley et al. . Click to enlarge. Washington State University ...
Beaufort Securities Breakfast Today including S... [Published Proactiveinvestors United Kingdom website - Sep 11 2014]
The Markets Market opening: Markets are likely to open higher today. FTSE 100 futures were trading 12.5 points up at 7:00 am. New York: Wall Street partially rebounded from its earlier losses, aided by a rally in social media stocks. Speculation over ...
New catalytic system for conversion of CO2 to m... [Published Green Car Congress - Aug 01 2014]
Scanning tunneling microscope image of a cerium-oxide and copper catalyst (CeOx-Cu) used in the transformation of CO2 and H2 to methanol (CH3OH) and water. In the presence of hydrogen, the Ce4+ and Cu1+ are reduced to Ce3+ and Cu0 with a change in ...
Altered Microbial Enzyme Eats Up Cocaine, Could... [Published Popular Science - New Technology, Science News, ... - Jun 24 2014]
A Pile Of Cocainevia STV Glasgow Bacteria that live in the soil near coca plants make an enzyme called cocaine esterase , which rapidly breaks down the drug. The enzyme could theoretically be useful to  destroy cocaine ingested by people before ...
Covalent Fragments [Published In the Pipeline - May 30 2014]
Many drug discovery researchers now have an idea of what to expect when a fragment library is screened against a new target. And some have had the experience of screening covalent, irreversible inhibitor structures against targets (a hot topic in recent ...
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Press Releases

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Successful Test of Solve H2O(TM) Treatment Syst... [Published GlobeNewswire: Acquisitions News - May 20 2014]
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