Active Site

Type: Keyphrase
Name: Active Site
First reported Apr 17 2014 - Updated Apr 17 2014 - 1 reports

Thermodynamics of Water in an Enzyme Active Site: Grid-Based Hydration Analysis of Coagulation Factor Xa

Water molecules in the active site of an enzyme occupy a complex, heterogeneous environment, and the thermodynamic properties of active-site water are functions of position. As a consequence, it is thought that an enzyme inhibitor can gain affinity by ... [Published Journal of Chemical Theory and Computation - Apr 17 2014]
Entities: Enzyme, Ligand, Molecule
First reported Apr 17 2014 - Updated Apr 17 2014 - 1 reports

Synthesizing Nitrogen-Doped Activated Carbon and Probing its Active Sites for Oxygen Reduction Reaction in Microbial Fuel Cells

Cost-effective cathode catalysts are critical to the development of microbial fuel cell (MFC) technology. Herein, a synthesis route is presented to improve the nitrogen content and nitrogen functionality in the nitrogen-doped activated carbon (AC) as ... [Published ACS Applied Materials & Interfaces - Apr 17 2014]
First reported Apr 13 2014 - Updated Apr 13 2014 - 1 reports

Half a million widely trusted websites vulnerable to Heartbleed bug

Posted in: Legal & Security at 13/04/2014 20:41A serious overrun vulnerability in the OpenSSL cryptographic library affects around 17% of SSL web servers which use certificates issued by trusted certificate authorities. Already commonly known as the Heartbleed ... [Published Goldstein Report - Apr 13 2014]
First reported Apr 11 2014 - Updated Apr 11 2014 - 1 reports

Researchers at Cornell University College of Medicine Target Tuberculosis

(NewsRx) -- By a News Reporter-Staff News Editor at Tuberculosis Week -- Research findings on Mycobacterium Infections are discussed in a new report. According to news reporting from New York City, New York, by NewsRx journalists, research stated, "The ... [Published NewsRX - Apr 11 2014]
First reported Apr 10 2014 - Updated Apr 10 2014 - 1 reports

Molecular Dynamics Study of Helicobacter pylori Urease

Helicobacter pylori have been implicated in an array of gastrointestinal disorders including, but not limited to, gastric and duodenal ulcers and adenocarcinoma. This bacterium utilizes an enzyme, urease, to produce copious amounts of ammonia through ... [Published Journal of Chemical Theory and Computation - Apr 10 2014]
First reported Apr 10 2014 - Updated Apr 10 2014 - 1 reports

Molecular basis of NpmA action on the 30S subunit [Biochemistry]

, Kellie Vinal , Pooja M. Desai , Natalia Zelinskaya , Miloje Savic , Dayne M. West , Graeme L. Conn 1 , and Christine M. Dunham 1 Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322Edited by Rachel Green, The Johns ... [Published PNAS - Apr 10 2014]
First reported Apr 08 2014 - Updated Apr 08 2014 - 1 reports

Enzyme catalysis of the hydrogen-oxygen reaction [Chemistry]

Philip Wulff a , Christopher C. Day b , Frank Sargent c , and Fraser A. Armstrong a , 1 a Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, United Kingdom; b Department of Earth Sciences, University of ... [Published PNAS - Apr 08 2014]
First reported Apr 07 2014 - Updated Apr 07 2014 - 1 reports

Isolation of cyanoformate suggests new carbon capture approaches

The formation of the cyanoformate ion helps to explain why plants' ethylene producing enzymes aren't poisoned by cyanide © Science/AAASResearchers have for the first time isolated the fragile and elusive cyanoformate ion , and in doing so have not only ... [Published RSC - Apr 07 2014]
First reported Apr 05 2014 - Updated Apr 05 2014 - 1 reports

Tanks protest in Cornwall needs to be more effective

The ever-unfolding saga of the off-again, on-again construction of chemical storage tanks on the Cornwall waterfront has been producing a healthy quantity of news in the last two weeks.For those catching up (like me), we've gone from a stagnant site with ... [Published Cornwall Standard-Freeholder - Apr 05 2014]
First reported Apr 02 2014 - Updated Apr 02 2014 - 1 reports

Studies from University of Wisconsin Reveal New Findings on Cell Biology

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Life Science Research . According to news reporting out of Madison, Wisconsin , by NewsRx editors, research stated, "Proper activation of protein phosphatase ... [Published 4 Traders - Apr 02 2014]
First reported Apr 02 2014 - Updated Apr 02 2014 - 1 reports

Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal

Reactive dicarbonyl species, such as methylglyoxal (MGO), are considered as the major precursors of advanced glycation end products (AGEs), which are believed to be one of the physiological causes of diabetes and its complications. Scavenging of reactive ... [Published Journal of Agricultural and Food Chemistry - Apr 02 2014]
First reported Mar 31 2014 - Updated Mar 31 2014 - 1 reports

Chelator Fragment Library from OTAVA

- OTAVA Ltd. offers new Chelator Fragment Library that comprises 575 compounds. The assembled library contains compounds with chelating groups only.Approximately half of all proteins contain metal ions in the active site for their biological activity. ... [Published PR inside - Mar 31 2014]
Entities: Protein, Active Site, Ion

Quotes

The following quote was obtained by the news editors from the background information supplied by the inventors: "While there are numerous compositions and methods known in the art to treat pain and/or inflammation, numerous difficulties remain. Most significantly, side effects over long administration periods and/or higher dosages often prevent successful use of such drugs. For example, certain COX-2 inhibitors have recently been implicated in adverse cardiovascular events, while aspirin-type pain medication often increases the risk of intestinal bleeding. In other examples, ibuprofen and acetaminophen tend to negatively impact hepatic function, especially at higher dosages."

More Content

All (93) | News (88) | Reports (0) | Blogs (4) | Audio/Video (0) | Fact Sheets (1) | Press Releases (0)
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Target-Specific Oral Anticoagulants [Published U.S.Pharmacist - 8 hours ago]
Polyethyleneimine as a Promoter Layer for the I... [Published Analytical Chemistry - 10 hours ago]
"Compositions and Methods of Inhibiting N-Acyle... [Published 4 Traders - Apr 17 2014]
Bioinspired manganese(II) complexes with a clic... [Published RSC - Apr 17 2014]
Celgene : Patent Issued for Preparation of Romi... [Published 4 Traders - Apr 17 2014]
Patent Issued for Method for Treating Thrombosi... [Published HispanicBusiness.com - Apr 17 2014]
Thermodynamics of Water in an Enzyme Active S... [Published Journal of Chemical Theory and Computation - Apr 17 2014]
Synthesizing Nitrogen-Doped Activated Carbon an... [Published ACS Applied Materials & Interfaces - Apr 17 2014]
QUIDEL : Patent Issued for Methods of Use for a... [Published 4 Traders - Apr 16 2014]
Discovery of Novel Allosteric Effectors Based o... [Published PLoS medicine - Apr 15 2014]
Evolution of the F-Box Gene Family in Euarchont... [Published PLoS medicine - Apr 14 2014]
Half a million widely trusted websites vulnerab... [Published Goldstein Report - Apr 13 2014]
Researchers at Cornell University College of Me... [Published NewsRX - Apr 11 2014]
Oxygen Pathways and Allostery in Monomeric Sar... [Published Journal of Chemical Theory and Computation - Apr 11 2014]
Molecular Dynamics Study of Helicobacter pylor... [Published Journal of Chemical Theory and Computation - Apr 10 2014]
Patent Issued for Cyclosporin Analogues [Published 4 Traders - Apr 10 2014]
Molecular basis of NpmA action on the 30S subun... [Published PNAS - Apr 10 2014]
Researchers from Technion-Israel Institute of T... [Published HispanicBusiness.com - Apr 10 2014]
No! Not the list of stumpers again! [Pharyngula] [Published ScienceBlogs : Combined Feed - Apr 09 2014]
NWR to delay Paskov coal mine closure in Czech ... [Published Mining Technology - Apr 09 2014]
Half a million widely trusted websites vulnerab... [Published Netcraft - Apr 09 2014]
F-box protein complex FBXL19 regulates TGFβ1-in... [Published MOLECULAR CANCER - Apr 08 2014]
Enzyme catalysis of the hydrogen-oxygen reactio... [Published PNAS - Apr 08 2014]
New family of Cu-only SODs in a fungal pathogen... [Published PNAS - Apr 08 2014]
Isolation of cyanoformate suggests new carbon c... [Published RSC - Apr 07 2014]
Tanks protest in Cornwall needs to be more effe... [Published Cornwall Standard-Freeholder - Apr 05 2014]
Taming a poison: Saving plants from cyanide wit... [Published PhysOrg.com - Apr 03 2014]
NZ Post quits unprofitable online service [Published MSN New Zealand - Apr 03 2014]
NZ Post quits unprofitable Localist experiment [Published Scoop - Apr 03 2014]
Studies from University of Wisconsin Reveal New... [Published 4 Traders - Apr 02 2014]
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Blogs

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No! Not the list of stumpers again! [Pharyngula] [Published ScienceBlogs : Combined Feed - Apr 09 2014]
There’s a common tactic used by creationists, and I’ve encountered it over and over again. It’s a form of the Gish Gallop: present the wicked evolutionist with a long list of assertions, questions, and non sequiturs, and if they answer with “I don’t ...
Across an ocean, finding his dream [Published MIT News feed - Feb 21 2014]
In 11th grade, when many high-school students are working on college applications, juggling extracurriculars, and taking multiple AP courses, Suan Tuang was doing the same. But at 16, Tuang was also striving to learn English, settle into a new home in ...
New family of enzymes to degrade biomass into c... [Published Green Car Congress - Dec 23 2013]
Researchers from the University of York (UK) and Aix-Marseille Université (France) have discovered a new family of enzymes that can degrade hard-to-digest biomass into its constituent sugars. They report on the new family of lytic polysaccharide monooxygenases ...
Unraveling An Off-Rate [Published In the Pipeline - Oct 29 2013]
Medicinal chemists talk a lot more about residence time and off rate than they used to. It's become clear that (at least in some cases) a key part of a drug's action is its kinetic behavior, specifically how quickly it leaves its binding site. You'd ...
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