Alphavirus

Type: Keyphrase
Name: Alphavirus
First reported 17 hours ago - Updated 17 hours ago - 1 reports

Nanocrystalline cellulose modified into an efficient viral inhibitor

By a News Reporter-Staff News Editor at Life Science Weekly -- There are many viral diseases in the world for which no pharmaceutical treatment exists. These include, among others, dengue fever, which is spread by mosquitoes in the tropics, as well as ... [Published 4 Traders - 17 hours ago]
First reported Apr 23 2014 - Updated Apr 23 2014 - 1 reports

Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development

Chikungunya virus (CHIKV) is an Alphavirus that causes chronic and incapacitating arthralgia in humans. Although patient cohort studies have shown the production of CHIKV specific antibodies, the fine specificity of the antibody response against CHIKV ... [Published PLoS medicine - Apr 23 2014]
Entities: Macaque, Antibody, Protein, Serum
First reported Apr 15 2014 - Updated Apr 15 2014 - 1 reports

UAB Building Drug Discovery Center To Combat West Nile Virus And Influenza

By Marcus JohnsonThe University of Alabama at Birmingham announced last month that it is building a new drug discovery center in order to develop drug treatments for viral infections with limited options for treatment. The UAB School of Medicine is leading ... [Published Bioresearch Online - Apr 15 2014]
First reported Apr 15 2014 - Updated Apr 15 2014 - 2 reports

Research shows bone loss causes joint pain from alphaviral diseases

Osteoblasts actively synthesizing osteoid. Credit: Robert M. Hunt; Wikipedia.(Medical Xpress)—Arthritogenic alphaviruses such as Ross River virus (RRV) cause disabling joint pain. To understand what causes this pain, Suresh Mahalingam of Griffith University ... [Published Medical Xpress - Apr 15 2014]
First reported Apr 02 2014 - Updated Apr 02 2014 - 1 reports

Study Data from Tulane National Primate Research Center Update Understanding of Encephalitis Viruses

By a News Reporter-Staff News Editor at Vaccine Weekly -- Investigators publish new report on RNA Viruses. According to news originating from Covington, Louisiana, by NewsRx correspondents, research stated, "Eastern equine encephalitis virus (EEEV) is ... [Published HighBeam Research - Apr 02 2014]
First reported Mar 25 2014 - Updated Mar 25 2014 - 1 reports

Synthesis of Cellulose Nanocrystals Carrying Tyrosine Sulfate Mimetic Ligands and Inhibition of Alphavirus Infection

We present two facile approaches for introducing multivalent displays of tyrosine sulfate mimetic ligands on the surface of cellulose nanocrystals (CNCs) for application as viral inhibitors. We tested the efficacy of cellulose nanocrystals, prepared either ... [Published Biomacromolecules - Mar 25 2014]
First reported Mar 25 2014 - Updated Mar 25 2014 - 1 reports

VLP Therapeutics Appoints Dr. Ryuji Ueno as Chair and Chief Medical Officer

/PRNewswire/ -- VLP Therapeutics, Inc. ("VLP"), a Rockville-based biotechnology company focusing on the research and development of next generation antibody agents and therapeutic as well as preventive vaccines based upon a novel and proprietary i-αVLP ... [Published BusinessWeek - Mar 25 2014]
First reported Mar 20 2014 - Updated Mar 21 2014 - 2 reports

Multimillion-Dollar Antiviral Drug Discovery Center Aims to Take on West Nile, Influenza

Viral infections with limited or no treatment options can pose a major global health threat, but a new national research consortium centered at the University of Alabama at Birmingham is focused on the discovery of new and better drug therapies as these ... [Published Infection Control Today - Mar 21 2014]
First reported Mar 19 2014 - Updated Mar 19 2014 - 1 reports

Patent Application Titled "Methods and Compositions for Pseudoinfectious Alphaviruses" Published Online

By a News Reporter-Staff News Editor at Life Science Weekly -- According to news reporting originating from Washington, D.C. , by NewsRx journalists, a patent application by the inventors Frolov, Ilya ( Birmingham, AL ); Frolova, Elena ( Birmingham, AL ... [Published 4 Traders - Mar 19 2014]
First reported Feb 12 2014 - Updated Feb 13 2014 - 3 reports

PRO/EDR> Chikungunya (16): Caribbean (Anguilla)

Chikungunya -- Worldwide/UnknownThe Ministry of Health wishes to advise that 4 more additional cases of chikungunya [virus infection] have been diagnosed in Anguilla and confirmed by the Public Health Agency (CARPHA) office located in Trinidad and Tobago. ... [Published HealthMap Global Disease Alerts - Feb 13 2014]
First reported Feb 07 2014 - Updated Feb 07 2014 - 1 reports

[Correspondence] Chikungunya in the Americas

Chikungunya is an arthropod-borne disease transmitted by aedes mosquitoes, characterised by febrile arthralgia and responsible for devastating outbreaks. No licensed vaccine or specific treatment is currently available. Since 2005, the East Central South ... [Published The Lancet - Feb 07 2014]
First reported Jan 30 2014 - Updated Jan 30 2014 - 1 reports

Trick that aids viral infection is identified

Fred Murphy, Sylvia Whitfield/CDC Scientists have discovered a defense system — built into some viruses — that may be vulnerable to treatment. The researchers studied alphaviruses similar to the Eastern equine encephalitis virus, pictured above in red. ... [Published WUSTL Medicine & Healthcare News - Jan 30 2014]
Entities: Virus, Stem-Loop, RNA, Infectious

Quotes

"It would be possible to provide protection against viruses, spread by mosquitoes, by applying ointment containing nanocrystalline cellulose onto the skin. Nanocrystalline cellulose applied on hospital door handles could kill viruses and prevent them from spreading. However, we first need to ascertain if the compounds will remain effective in a non-liquid form and how they work in animal tests" she ponders
...According to news originating from Covington, Louisiana, by NewsRx correspondents, research stated, "Eastern equine encephalitis virus (EEEV) is a mosquito-borne alphavirus that causes sporadic, often fatal disease outbreaks in humans and equids, and is also a biological threat agent. Two chimeric vaccine candidates were constructed using a cDNA clone with a Sindbis virus (SINV) backbone and structural protein genes from either a North (SIN/NAEEEV) or South American (SIN/SAEEEV) strain of EEEV."
...Wataru Akahata, Ph D , Co-Founder and Chief Executive Officer of VLP. "I established VLP in order to create a revolutionary vaccine therapy that provides the greater social impact and is accessible by the patients globally who are underserved by or cannot access the current treatments. With the expertise of Dr. Ueno, I believe we can now facilitate the researchresearch and development of our compounds to initiate the clinical development to create new medication for a number of patients with unmet medical need" continued Dr. Akahata
"The present invention overcomes previous shortcomings in the art by providing pseudoinfectious alphaviruses (PIV), combining the efficiency of live attenuated vaccines (LAVs), which results from the ability of the PIV genome to replicate and produce subviral particles (SVPs), with the safety of inactivated (INV) viral vaccines, due to the inability of PIV to develop a spreading infection."

More Content

All (20) | News (15) | Reports (0) | Blogs (5) | Audio/Video (0) | Fact Sheets (0) | Press Releases (0)
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Nanocrystalline cellulose modified into an effi... [Published 4 Traders - 17 hours ago]
Unique Epitopes Recognized by Antibodies Induce... [Published PLoS medicine - Apr 23 2014]
UAB Building Drug Discovery Center To Combat We... [Published Bioresearch Online - Apr 15 2014]
Research shows bone loss causes joint pain from... [Published Medical Xpress - Apr 15 2014]
Alphaviral infection triggers pathologic bone l... [Published PNAS - Apr 15 2014]
Small Bite: Big Threat: Chikungunya [Published Sify - Apr 04 2014]
Chikungunya outbreak in the Caribbean region, D... [Published Eurosurveillance - Apr 03 2014]
Study Data from Tulane National Primate Researc... [Published HighBeam Research - Apr 02 2014]
Synthesis of Cellulose Nanocrystals Carrying Ty... [Published Biomacromolecules - Mar 25 2014]
VLP Therapeutics Appoints Dr. Ryuji Ueno as Cha... [Published BusinessWeek - Mar 25 2014]
Multimillion-Dollar Antiviral Drug Discovery Ce... [Published Infection Control Today - Mar 21 2014]
Multimillion-Dollar Antiviral Drug Discovery Ce... [Published Newswise - Mar 20 2014]
Patent Application Titled "Methods and Composit... [Published 4 Traders - Mar 19 2014]
PRO/EDR> Chikungunya (16): Caribbean (Anguilla) [Published HealthMap Global Disease Alerts - Feb 13 2014]
BH : Chikungunya Outbreak / Caribean Area / Ang... [Published RSOE EDIS - EBHWM - Feb 12 2014]
Biological Hazard - Caribean Area - Anguilla [Published RSOE EDIS - Emergency and Disaster Information - Feb 12 2014]
[Correspondence] Chikungunya in the Americas [Published The Lancet - Feb 07 2014]
Trick that aids viral infection is identified [Published WUSTL Medicine & Healthcare News - Jan 30 2014]
More on chikungunya in St. Martin/Sint Maarten [Published H5N1 - Dec 31 2013]
Treatment of conditions involving demyelination [Published PharmCast - Aug 02 2013]
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BH : Chikungunya Outbreak / Caribean Area / Ang... [Published RSOE EDIS - EBHWM - Feb 12 2014]
EDIS Number: BH-20140212-42653-AIA Date / time: 12/02/2014 04:23:45 [UTC] Event: Biological Hazard Name of Hazard: Chikungunya Outbreak Area: Caribean Area Country: Anguilla Description: The Ministry of Health wishes to advise that four (4) more ...
Biological Hazard - Caribean Area - Anguilla [Published RSOE EDIS - Emergency and Disaster Information - Feb 12 2014]
EDIS Number: BH-20140212-42653-AIA Date / time: 12/02/2014 04:23:45 [UTC] Event: Biological Hazard Area: Caribean Area Country: Anguilla State/County: Location: [Nationwide] Number of Deads: N/A Number of Injured: N/A Number of Infected: ...
[Correspondence] Chikungunya in the Americas [Published The Lancet - Feb 07 2014]
Chikungunya is an arthropod-borne disease transmitted by aedes mosquitoes, characterised by febrile arthralgia and responsible for devastating outbreaks. No licensed vaccine or specific treatment is currently available. Since 2005, the East Central South ...
Trick that aids viral infection is identified [Published WUSTL Medicine & Healthcare News - Jan 30 2014]
Fred Murphy, Sylvia Whitfield/CDC Scientists have discovered a defense system — built into some viruses — that may be vulnerable to treatment. The researchers studied alphaviruses similar to the Eastern equine encephalitis virus, pictured above in red. ...
More on chikungunya in St. Martin/Sint Maarten [Published H5N1 - Dec 31 2013]
Via St. Martin News Network, a December 27 report: Ministry of Public Health reports one confirmed case of Chikungunya; Residents urgently advised to be proactive in eliminating mosquito breeding sites. Excerpt:Collective Prevention Services (CPS), an ...
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