ATPase

Type: Keyphrase
Name: ATPase
First reported 5 hours ago - Updated 5 hours ago - 1 reports

Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase

Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation ... [Published Free Patents Online - 5 hours ago]
First reported Oct 20 2014 - Updated Oct 20 2014 - 1 reports

Regulation of PKC Mediated Signaling by Calcium during Visceral Leishmaniasis

by Nivedita Roy, Supriya Chakraborty, Bidisha Paul Chowdhury, Sayantan Banerjee, Kuntal Halder, Saikat Majumder, Subrata Majumdar, Parimal C. SenCalcium is an ubiquitous cellular signaling molecule that controls a variety of cellular processes and is ... [Published Plosone.org - Oct 20 2014]
First reported Oct 18 2014 - Updated Oct 18 2014 - 1 reports

Investigation of membrane protein-protein interactions using correlative FRET-PLA

Investigation of membrane protein–protein interactions using correlative FRET-PLAAbstractFluorescence resonance energy transfer (FRET) analysis and the recently developed proximity ligation assay (PLA) are widely used to study protein–protein interactions ... [Published Bio Techniques - Oct 18 2014]
First reported Oct 17 2014 - Updated Oct 17 2014 - 1 reports

Biosensors : Change - Announcement Of Appointment Non-Executive Independent Director

Dr Jinsong Bian, is an Associate Professor in Department of Pharmacology, Yong Loo Ling School of Medicine, National University of Singapore, Singapore. He was first appointed as an assistant professor in 2003 and then an associate professor with tenure ... [Published 4 Traders - Oct 17 2014]
First reported Oct 16 2014 - Updated Oct 16 2014 - 1 reports

New Peptides and Proteins Findings from RIKEN Described (CHARMM Force-Fields with Modified Polyphosphate Parameters Allow Stable Simulation of the...

New Peptides and Proteins Findings from RIKEN Described (CHARMM Force-Fields with Modified Polyphosphate Parameters Allow Stable Simulation of the ATP-Bound Structure of Ca2+-ATPase)By a News Reporter-Staff News Editor at Life Science Weekly -- Current ... [Published 4 Traders - Oct 16 2014]
First reported Oct 09 2014 - Updated Oct 09 2014 - 1 reports

Suramin Inhibits Hsp104 ATPase and Disaggregase Activity

IntroductionFor proteins to perform their biological function, folding into the appropriate three-dimensional shape is of paramount importance [1] . Protein misfolding can result in cellular toxicity and lead to catastrophic diseases, such as Parkinson ... [Published Plosone.org - Oct 09 2014]
First reported Oct 08 2014 - Updated Oct 08 2014 - 1 reports

Vertex Pharmaceuticals : Patent Issued for Solid Forms of 3-(6-(1-(2,2-Difluorobenzodioxo1-5-Yl) Cyclopropanecarboxamido)-3-Methylpyridin-2-Yl) Benzoic Acid

By a News Reporter-Staff News Editor at Pharma Business Week -- From Alexandria, Virginia , NewsRx journalists report that a patent by the inventors Keshavarz-Shokri, Ali ( San Diego, CA ); Zhang, Beili ( San Diego, CA ); Krawiec, Mariusz ( Marlborough, ... [Published 4 Traders - Oct 08 2014]
First reported Sep 30 2014 - Updated Sep 30 2014 - 1 reports

XPD - Different Jobs in Repair and Transcription

Comparative Mutagenesis of Human and Fungal XPDProteins from the fungus Chaetomium thermophilum provide an ideal basis to perform biochemical studies, as they are closely related to their human homologues but are significantly more stable and thus amenable ... [Published PLoS Biology - Sep 30 2014]
First reported Sep 26 2014 - Updated Sep 26 2014 - 1 reports

Acuminolide A: Structure and Bioactivity of a New Polyether Macrolide from Dinoflagellate Dinophysis acuminata

Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was ... [Published Organic Letters - Sep 26 2014]
First reported Sep 26 2014 - Updated Sep 26 2014 - 1 reports

Plasma membrane H+-ATPase regulation is required for auxin gradient formation preceding phototropic growth

IntroductionThe ability of plants to adjust their growth to the direction of incoming light already intrigued Greek philosophers in ancient times (Whippo & Hangarter, 2006 ) and lost nothing of its fascination today. Several key steps of this process ... [Published Molecular Systems Biology - Sep 26 2014]
First reported Sep 26 2014 - Updated Sep 26 2014 - 1 reports

Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in ...

Glioblastoma multiforme (GBM) is very difficult to treat with conventional anti-cancer/anti-apoptotic drugs. We tested the hypothesis that inhibition of Na+/K+-ATPase causess a mixed or hybrid form of concurrent apoptosis and necrosis and therefore should ... [Published 7thSpace - Sep 26 2014]
First reported Sep 25 2014 - Updated Sep 25 2014 - 1 reports

Derlin-1 Regulates Mutant VCP-Linked Pathogenesis and Endoplasmic Reticulum Stress-Induced Apoptosis

by Cyong-Jhih Liang, Ya-Chu Chang, Henry C. Chang, Chung-Kang Wang, Yu-Chien Hung, Ying-Er Lin, Chia-Ching Chan, Chun-Hong Chen, Hui-Yun Chang, Tzu-Kang SangMutations in VCP (Valosin-containing protein), an AAA ATPase critical for ER-associated degradation, ... [Published Plosone.org - Sep 25 2014]

Quotes

According to the news editors, the research concluded: "These simulations suggest that the modified parameters will be useful in studies of ATP in solution and of the many ATP-utilizing proteins."
"Processes described herein can be used to prepare the compositions of this invention comprising Form I The amounts and the features of the components used in the processes would be as described herein."
"A number of such reagents have been tested for their potential in protecting the dopaminergic neurons against oxidative cell stress in rodent models of PD. For example, crocetin was proved to ameliorate symptoms in a hemi-parkinsonian rat model by increasing SOD activity and the GSH level (Ahmad et al., 'Neuroprotection by crocetin in a hemi-parkinsonian rat model,' Pharmacol Biochem Behav, 81:805-813 (2005)). In addition, one study suggested that coenzyme Q10 reduced the depletion of TH-positive DA neurons in a chronic dosing model of PD induced by 1-methyl-4-phenylpyridinium (MPP.sup.+) (Cleren et al., 'Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism J Neurochem, 104:1613-1621 (2008)). Other anti-oxidant reagents with similar properties include N-acetylcysteine ( Bagh et al., 'Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's disease,' Free Radic Res, 42:574-581 (2008)), polyhydroxylated fullerene derivative such as C(60)(OH) (Cai et al., 'Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+)-induced cellular model of Parkinson's disease,' J Neurosci Res, 86:3622-3634 (2008)), and herbal extracts such as green tea polyphenols or catechins (Chung et al., 'Epigallocatechin gallate (EGCG) potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y cells,' Brain Res , 1176:133-142 (2007); Wang et al., 'Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins,' Neurochem Int, 54:43-48 (2009); Rojas et al., 'Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson's disease,' Nutrition, 25:482-485 (2009))."

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Methods and compositions for inhibition of the ... [Published Free Patents Online - 5 hours ago]
Impairment of Lysosomal Activity as a Therapeut... [Published Plosone.org - 15 hours ago]
Regulation of PKC Mediated Signaling by Calcium... [Published Plosone.org - Oct 20 2014]
Investigation of membrane protein-protein inter... [Published Bio Techniques - Oct 18 2014]
Biosensors : Change - Announcement Of Appointme... [Published 4 Traders - Oct 17 2014]
New Peptides and Proteins Findings from RIKEN D... [Published 4 Traders - Oct 16 2014]
Suramin Inhibits Hsp104 ATPase and Disaggregase... [Published Plosone.org - Oct 09 2014]
Vertex Pharmaceuticals : Patent Issued for Soli... [Published 4 Traders - Oct 08 2014]
Researchers Submit Patent Application, "Use of ... [Published 4 Traders - Oct 08 2014]
Molecular Medicine : New Cellular and Molecular... [Published 4 Traders - Oct 08 2014]
Gene Expression Analysis in Tubule Interstitial... [Published Sexual Development - Oct 06 2014]
Effects of Human Parvovirus B19 and Bocavirus V... [Published Plosone.org - Sep 30 2014]
Ultraslow Myosin Molecular Motors of Placental ... [Published Plosone.org - Sep 30 2014]
XPD - Different Jobs in Repair and Transcription [Published PLoS Biology - Sep 30 2014]
The Role of Mitochondria in T-2 Toxin-Induced H... [Published Plosone.org - Sep 29 2014]
Changes in brain metabolites in experimental ce... [Published JPMA - Sep 29 2014]
Sodium glucose transporter 2 (sglt2) inhibitors... [Published JPMA - Sep 29 2014]
Acuminolide A: Structure and Bioactivity of a N... [Published Organic Letters - Sep 26 2014]
Plasma membrane H+-ATPase regulation is require... [Published Molecular Systems Biology - Sep 26 2014]
Inhibition of Na+/K+-ATPase induces hybrid cell... [Published 7thSpace - Sep 26 2014]
Derlin-1 Regulates Mutant VCP-Linked Pathogenes... [Published Plosone.org - Sep 25 2014]
Anterograde Activin Signaling Regulates Postsyn... [Published Plosone.org - Sep 25 2014]
Ganglioside Regulation of AMPA Receptor Traffic... [Published Journal of Neuroscience - Sep 24 2014]
Masked mycotoxins [Published Engormix.com - Sep 23 2014]
The Chromatin Remodeling Factor CHD5 Is a Trans... [Published Plosone.org - Sep 23 2014]
Reports from National Heart Lung and Blood Inst... [Published HispanicBusiness.com - Sep 18 2014]
Cassava leaves, roots show promise against colo... [Published The Guardian Nigeria - Sep 18 2014]
In Silico Drug Discovery Conference Announces S... [Published BioSpace - Sep 17 2014]
Studies from ONIRIS Describe New Findings in Ge... [Published HispanicBusiness.com - Sep 17 2014]
Confirmation of Cause and Manner of Death Via a... [Published Insurance News Net - Sep 17 2014]
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Medical marijuana and the new herbalism, part 2... [Published ScienceBlogs : Combined Feed - Aug 18 2014]
About five weeks ago a month ago, I finally wrote the post I had been promising to write for months before about medical marijuana . At the time, I also promised that there would be follow-up posts. Like Dug the Dog seeing a squirrel, I kept running ...
Medical marijuana as the new herbalism, part 2:... [Published Science-Based Medicine - Aug 11 2014]
About a month ago, I finally wrote the post I had been promising to write for months before about medical marijuana . At the time, I also promised that there would be follow up posts. Like Dug the Dog seeing a squirrel, I kept running into other ...
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