DNA Methylation

Type: Keyphrase
Name: DNA Methylation
First reported 2 hours ago - Updated 2 hours ago - 1 reports

Virginia Bioinformatics Institute researchers use new technique to shed light on inherited diseases

BLACKSBURG, Va., Sept. 2, 2014 – In 1957, Conrad Waddington published a landmark essay collection that explained a concept he called "the epigenetic landscape."It described how a cell moves through the process of cellular differentiation, becoming a blood ... [Published Virginia Tech - 2 hours ago]
First reported Sep 01 2014 - Updated Sep 01 2014 - 1 reports

A Long Line of LINEs

Different mechanisms repress mobile DNA elements in human embryonic stem cells depending on the elements’ evolutionary ages.ROUTES TO REPRESSION: The oldest LINE-1 transposons in the human genome are no longer transcribed due to the accumulation of mutations ... [Published The Scientist - Sep 01 2014]
First reported Aug 30 2014 - Updated Aug 30 2014 - 1 reports

Can we predict stress-related illnesses?

By Rosanne Fohn - SAN ANTONIO―Scientists studying depression in teens have discovered that subtle changes in a gene can predict how the brain reacts to stress, which can cause such health issues as depression, post-traumatic stress disorder and obesi ... [Published Health Canal - Aug 30 2014]
First reported Aug 29 2014 - Updated Aug 29 2014 - 1 reports

Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study

by Aldo Córdova-Palomera, Silvia Alemany, Mar Fatjó-Vilas, Ximena Goldberg, Juan Carlos Leza, Ana González-Pinto, Igor Nenadic, Lourdes FañanásNeurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes ... [Published Plosone.org - Aug 29 2014]
First reported Aug 28 2014 - Updated Aug 28 2014 - 1 reports

How silent genes are activated

DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation have been documented, involving genome-wide and gene-specific DNA demethylation. How demethylating ... [Published Health Canal - Aug 28 2014]
First reported Aug 28 2014 - Updated Aug 28 2014 - 1 reports

"Method to Estimate Age of Individual Based on Epigenetic Markers in Biological Sample" in Patent Application Approval Process

By a News Reporter-Staff News Editor at Life Science Weekly -- A patent application by the inventors Vilain, Eric ( Los Angeles, CA ); Bocklandt, Sven ( Los Angeles, CA ); Horvath , Steve ( Los Angeles, CA ); Sinsheimer, Janet ( Los Angeles, CA ), filed ... [Published HispanicBusiness.com - Aug 28 2014]
First reported Aug 28 2014 - Updated Aug 28 2014 - 1 reports

Is society being reshaped on a microbiological and epigenetic level by the way women give birth?

In this fascinating piece, Hannah Dahlen, Professor of Midwifery, University of Western Sydney, approaches the issue from a microbiological and epigenetic perspective and discusses the evidence for a causal link between labor and birthing processes and ... [Published Crikey Media - Aug 28 2014]
First reported Aug 26 2014 - Updated Aug 26 2014 - 1 reports

Illumina : Presolicitation Notice - DNA Samples for Library Construction

Notice Type: Presolicitation NoticePosted Date: 25-AUG-14Office Address: Department of Health and Human Services; National Institutes of Health ; National Heart, Lung and Blood Institute , Rockledge Dr. Bethesda, MD ; Office of Acquisitions6701 Rockledge ... [Published 4 Traders - Aug 26 2014]
First reported Aug 26 2014 - Updated Aug 26 2014 - 1 reports

Marked methylation changes in intestinal genes during the perinatal period of preterm neonates

Research articleFei Gao , Juyong Zhang , Pingping Jiang , Desheng Gong , Jun-Wen Wang , Yudong Xia , Mette Viberg Østergaard , Jun Wang and Per Torp SangildBMC Genomics 2014, 15 :716doi:10.1186/1471-2164-15-716Published: 26 August 2014Abstract (provisional) ... [Published BMC - Aug 26 2014]
First reported Aug 26 2014 - Updated Aug 26 2014 - 1 reports

Modeling DNA methylation dynamics with approaches from phylogenetics

Motivation: Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates. Genome-wide DNA methylation assays have become increasingly common, and this has enabled characterization of DNA ... [Published Bioinformatics - Aug 26 2014]
First reported Aug 22 2014 - Updated Aug 22 2014 - 2 reports

Gene silencing via DNA methylation in naturally occurring Tragopogon miscellus (Asteraceae) ...

Hybridization coupled with whole-genome duplication (allopolyploidy) leads to a variety of genetic and epigenetic modifications in the resultant merged genomes. In particular, gene loss and gene silencing are commonly observed post-polyploidization.Here, ... [Published 7thSpace - Aug 22 2014]
First reported Aug 17 2014 - Updated Aug 18 2014 - 5 reports

DNA methylation in brain 'linked to Alzheimer's disease'

Ratings require JavaScript to be enabled. DNA methylation - the biochemical alteration of the building blocks of DNA - can indicate whether DNA is biologically active within a region of the human genome. Now, researchers at Brigham and Women's ... [Published Medical News Today - Aug 18 2014]

Quotes

...sequencing data with various '-omics' data to scrutinize the inheritance of DNA methylation patterns that are difficult to track," Xie said. "We made a number of interesting observations. For instance, accurate methylation inheritance is highly dependent on the binding of specific trans-factors to local sequences. In addition, the genome-wide hairpin bisulfite sequencing technique we developed provides several advantages over traditional strategies for DNA methylation studies and does not add to the cost of sequencing."
...First author Khelifa Arab says: "The results reveal a function of lncRNAs, serving as a genomic address label for GADD45A-mediated demethylation of specific target genes."
"As discussed in detail below, the methods of the invention can be adapted for use with a variety of art accepted processes. For example, in certain embodiments of the invention, a bisulfite conversion process is performed so that cytosine residues in the genomic DNA are transformed to uracil, while 5-methylcytosine residues in the genomic DNA are not transformed to uracil. Optionally, the genomic DNA is transformed from its natural state via amplification by a polymerase chain reaction process. In certain embodiments of the invention, the genomic DNA is hybridized to a complimentary sequence (e g. a synthetic polynucleotide sequence) that is coupled to a matrix (e g. one disposed within a microarray)."

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All (210) | News (168) | Reports (0) | Blogs (40) | Audio/Video (0) | Fact Sheets (0) | Press Releases (2)
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Virginia Bioinformatics Institute researchers u... [Published Virginia Tech - 2 hours ago]
Cerebral palsy may be hereditary [Published Health Canal - 22 hours ago]
Chromatin Immunoprecipitation: 10 Technical Tip... [Published Select Science - 22 hours ago]
A Long Line of LINEs [Published The Scientist - Sep 01 2014]
Can we predict stress-related illnesses? [Published Health Canal - Aug 30 2014]
Birth Weight, Working Memory and Epigenetic Sig... [Published Plosone.org - Aug 29 2014]
Specificity, propagation, and memory of pericen... [Published Molecular Systems Biology - Aug 28 2014]
How silent genes are activated [Published Health Canal - Aug 28 2014]
"Method to Estimate Age of Individual Based on ... [Published HispanicBusiness.com - Aug 28 2014]
Is society being reshaped on a microbiological ... [Published Crikey Media - Aug 28 2014]
Scientists map the ‘editing marks’ on fly, worm... [Published WUSTL Science & Technology News - Aug 27 2014]
Scientists map the 'editing marks' on fly, worm... [Published EurekAlert! - Aug 27 2014]
Illumina : Presolicitation Notice - DNA Samples... [Published 4 Traders - Aug 26 2014]
Epigenetic changes linked to Alzheimer's [Published BioNews - Aug 26 2014]
Do Breast Cancer Cell Lines Provide a Relevant ... [Published Plosone.org - Aug 26 2014]
Common Epigenomic Fingerprint Found in Multiple... [Published Genetic Engineering News - Aug 26 2014]
Marked methylation changes in intestinal genes ... [Published BMC - Aug 26 2014]
Modeling DNA methylation dynamics with approach... [Published Bioinformatics - Aug 26 2014]
One cancer – many tumors [Published Health Canal - Aug 26 2014]
Identification and Characterization of Germ Cel... [Published Plosone.org - Aug 26 2014]
Stock Update: Agilent Technologies Inc (NYSE:A)... [Published Jutia Group - Aug 25 2014]
Genetic Analysis Reveals How Honeybees Respond ... [Published Red Orbit - Aug 25 2014]
Change in DNA Methylation Patterns of SLC6A4 Ge... [Published Plosone.org - Aug 22 2014]
Methyl Donor-Deficient Diet during Development ... [Published Plosone.org - Aug 22 2014]
Encyclopedia of stem cells – Identification of ... [Published Health Canal - Aug 22 2014]
Gene silencing via DNA methylation in naturally... [Published 7thSpace - Aug 22 2014]
Gene silencing via DNA methylation in naturally... [Published BMC - Aug 22 2014]
Genome-wide DNA methylation profiles in progres... [Published 7thSpace - Aug 22 2014]
MethylAid: Visual and interactive quality contr... [Published Bioinformatics - Aug 22 2014]
Researchers Show Involvement Of DNA Modificatio... [Published Bioresearch Online - Aug 21 2014]
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Blogs

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Scientists map the ‘editing marks’ on fly, worm... [Published WUSTL Science & Technology News - Aug 27 2014]
iStock and Creative CommonsD. melanogaster, the fruit fly, (top) has served for more than 100 years as a model for human biology, while the transparent worm C. elegans (bottom) is a comparative newcomer with a 40-year service record.   The genome ...
Scientists discover how ‘jumping genes’ help bl... [Published UCLA Newsroom - Aug 05 2014]
Black truffles have a syrupy sweet flavor and are highly prized in haute cuisine. A study by an international team of scientists sheds new light on their unique pattern of DNA methylation, a biochemical process. ...
The dynamics of DNA methylation fidelity during... [Published Genome Research current issue - Aug 01 2014]
The faithful transmission of DNA methylation patterns through cell divisions is essential for the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment of methylation fidelity, we implemented a genome-scale hairpin bisulfite ...
Nucleosome repositioning links DNA (de)methylat... [Published Genome Research current issue - Aug 01 2014]
During differentiation of embryonic stem cells, chromatin reorganizes to establish cell type-specific expression programs. Here, we have dissected the linkages between DNA methylation (5mC), hydroxymethylation (5hmC), nucleosome repositioning, and binding ...
Interplay of TRIM28 and DNA methylation in cont... [Published Genome Research current issue - Aug 01 2014]
Reverse transcription-derived sequences account for at least half of the human genome. Although these retroelements are formidable motors of evolution, they can occasionally cause disease, and accordingly are inactivated during early embryogenesis through ...
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Press Releases

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Karyopharm Announces Initiation of a Phase 1 St... [Published GlobeNewswire: Acquisitions News - Apr 15 2014]
DBV Technologies and CEA conclude a scientific ... [Published GlobeNewswire: Advertising News - Apr 09 2014]
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