DNA Methylation

Type: Keyphrase
Name: DNA Methylation
First reported 23 hours ago - Updated 23 hours ago - 1 reports

DNA Methylation Signatures Triggered by Prenatal Maternal Stress Exposure to a Natural Disaster: Project Ice Storm

by Lei Cao-Lei, Renaud Massart, Matthew J. Suderman, Ziv Machnes, Guillaume Elgbeili, David P. Laplante, Moshe Szyf, Suzanne KingBackgroundPrenatal maternal stress (PNMS) predicts a wide variety of behavioral and physical outcomes in the offspring. Although ... [Published Plosone.org - 23 hours ago]
First reported Sep 20 2014 - Updated Sep 20 2014 - 1 reports

Global loss of DNA methylation uncovers intronic enhancers in genesshowing expression changes

Gene expression is epigenetically regulated by a combination of histone modifications and methylation of CpG dinucleotides in promoters. In normal cells, CpG-rich promoters are typically unmethylated, marked with histone modifications such as H3K4me3, ... [Published 7thSpace - Sep 20 2014]
First reported Sep 19 2014 - Updated Sep 19 2014 - 1 reports

Abnormal Ovarian DNA Methylation Programming during Gonad Maturation in Wild Contaminated Fish

There is increasing evidence that pollutants may cause diseases via epigenetic modifications. Epigenetic mechanisms such as DNA methylation participate in the regulation of gene transcription. Surprisingly, epigenetics research is still limited in ecotoxicology. ... [Published Environmental Science & Technology - Sep 19 2014]
First reported Sep 19 2014 - Updated Sep 19 2014 - 1 reports

Evaluation of microarray-based DNA methylation measurement using technical replicates: the ...

DNA methylation is a widely studied epigenetic phenomenon; alterations in methylation patterns influence human phenotypes and risk of disease. As part of the Atherosclerosis Risk in Communities (ARIC) study, the Illumina Infinium HumanMethylation450 (HM450) ... [Published 7thSpace - Sep 19 2014]
First reported Sep 19 2014 - Updated Sep 19 2014 - 1 reports

Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels

by Nicholas E. Banovich, Xun Lan, Graham McVicker, Bryce van de Geijn, Jacob F. Degner, John D. Blischak, Julien Roux, Jonathan K. Pritchard, Yoav GiladDNA methylation is an important epigenetic regulator of gene expression. Recent studies have revealed ... [Published Plosone.org - Sep 19 2014]
First reported Sep 16 2014 - Updated Sep 16 2014 - 1 reports

Lifestyle and Cancer-Associated DNA Change in the Colon

You JS, Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell . 2012;22(1):9–20.De Carvalho DD, Sharma S, You JS, et al. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell . ... [Published General Medicine eJournal - Sep 16 2014]
First reported Sep 13 2014 - Updated Sep 13 2014 - 1 reports

Lung Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis Exhibit Genome-Wide Differences in DNA Methylation Compared to Fibroblasts from Nonfibrotic Lung

by Steven K. Huang, Anne M. Scruggs, Richard C. McEachin, Eric S. White, Marc Peters-GoldenExcessive fibroproliferation is a central hallmark of idiopathic pulmonary fibrosis (IPF), a chronic, progressive disorder that results in impaired gas exchange ... [Published Plosone.org - Sep 13 2014]
First reported Sep 12 2014 - Updated Sep 12 2014 - 1 reports

TARGETING DNA METHYLATION TO THE GENOME

Patrick C.H. Lo, Ph.D.BioTechniques, Vol. 57, No. 3, September 2014, pp. 106–110AbstractProving direct relationships between DNA alterations and phenotypes is challenging. For epigenetics researchers, linking DNA methylation with human disease is no exception. ... [Published Bio Techniques - Sep 12 2014]
First reported Sep 09 2014 - Updated Sep 09 2014 - 1 reports

eMethylsorb: Electrochemical quantification of DNA methylation at CpG resolution using DNA-gold affinity interactions

We report a simple electrochemical method referred to as “eMethylsorb” for the detection of DNA methylation. The method relies on the base dependent affinity interaction of DNA with gold. The methylation status of DNA is quantified by monitoring electrochemical ... [Published RSC - Sep 09 2014]
First reported Sep 03 2014 - Updated Sep 03 2014 - 1 reports

Epigenome-Wide DNA Methylation in Hearing Ability: New Mechanisms for an Old Problem

by Lisa E. Wolber, Claire J. Steves, Pei-Chien Tsai, Panos Deloukas, Tim D. Spector, Jordana T. Bell, Frances M. K. WilliamsEpigenetic regulation of gene expression has been shown to change over time and may be associated with environmental exposures ... [Published Plosone.org - Sep 03 2014]
First reported Sep 02 2014 - Updated Sep 02 2014 - 2 reports

Researchers use new technique to shed light on inherited diseases

Hehuang Xie and two students at a laboratory bench look at samples.In 1957, Conrad Waddington published a landmark essay collection that explained a concept he called "the epigenetic landscape."It described how a cell moves through the process of cellular ... [Published Medical Xpress - Sep 02 2014]
First reported Aug 22 2014 - Updated Aug 22 2014 - 2 reports

Gene silencing via DNA methylation in naturally occurring Tragopogon miscellus (Asteraceae) ...

Hybridization coupled with whole-genome duplication (allopolyploidy) leads to a variety of genetic and epigenetic modifications in the resultant merged genomes. In particular, gene loss and gene silencing are commonly observed post-polyploidization.Here, ... [Published 7thSpace - Aug 22 2014]

Quotes

The work comes out of the molecular therapeutic laboratory directed by Richard G Moore, MD, of Women & Infants Program in Women's Oncology. Entitled "HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation" the research was recently published in the international science journal Scientific Reports, a Nature publishing group
...abiotic and biotic stress responses, DNA double-strand break repair, and plant development have been demonstrated," they state in the article. "These advancements in basic research have greatly increased our knowledge of plant ncRNAs and facilitated the effective design of ncRNA-based strategies for crop improvement. ncRNAs function by repressing the expression of endogenous or exogenous genes at the transcriptional, post-transcriptional, or translational levels in a sequence-specific manner … [and] can be used to specifically control the expression of target genes."
"Jim is a senior scientist who brings extensive experience to UPCI. He will assume leadership of the UPCI Lung Cancer SPORE grant and work closely with Dr. Mark Socinski in our Lung Cancer Program, strengthening an already impressive team" said Nancy E Davidson, M D , director of UPCI and the UPMC CancerCenter...
...Cecil, lead author of the study, from the InstituteInstitute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London says: "We were particularly interested in studying the oxytocin receptor gene, often referred to as the 'love hormone'. We know from previous studies that higher levels of DNA methylation in this gene relate to lower levels of oxytocin in the body. In turn, Oxytocin, has been shown to promote prosocial behaviour, such as empathy, trust, attachment and bonding, which are typically impaired in youth with CU traits. " The reers found that in youth with low levels of anxiety/depression, CU traits at 13 were associated with higher DNA methylation at the oxytocin receptor...

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All (182) | News (140) | Reports (0) | Blogs (40) | Audio/Video (0) | Fact Sheets (0) | Press Releases (2)
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DNA Methylation Signatures Triggered by Prenata... [Published Plosone.org - 23 hours ago]
Global loss of DNA methylation uncovers introni... [Published 7thSpace - Sep 20 2014]
Abnormal Ovarian DNA Methylation Programming d... [Published Environmental Science & Technology - Sep 19 2014]
Evaluation of microarray-based DNA methylation ... [Published 7thSpace - Sep 19 2014]
The Pathogenesis, Diagnosis and Treatment of Lu... [Published General Medicine eJournal - Sep 19 2014]
Methylation QTLs Are Associated with Coordinate... [Published Plosone.org - Sep 19 2014]
Rosa26 Locus Supports Tissue-Specific Promoter ... [Published Plosone.org - Sep 18 2014]
Primary piRNA biogenesis: caught up in a Maelstrom [Published EMBO Journal - Sep 17 2014]
Researchers examine role of hormone in response... [Published EurekAlert! - Sep 17 2014]
A Gene Panel, Including LRP12, Is Frequently Hy... [Published Plosone.org - Sep 17 2014]
Lifestyle and Cancer-Associated DNA Change in t... [Published General Medicine eJournal - Sep 16 2014]
Aberrant Promoter Methylation of Caveolin-1 Is ... [Published Plosone.org - Sep 15 2014]
In-Utero Methadone or Subutex Exposure Could Al... [Published Hospital Newspaper - Sep 15 2014]
Comparative Transcriptome Analysis of Climacter... [Published Plosone.org - Sep 13 2014]
Lung Fibroblasts from Patients with Idiopathic ... [Published Plosone.org - Sep 13 2014]
Human Stem Cell Clock Reset to Zero [Published Genetic Engineering News - Sep 12 2014]
TARGETING DNA METHYLATION TO THE GENOME [Published Bio Techniques - Sep 12 2014]
Human stem cells can be reset to their native u... [Published News-Medical.Net - Sep 12 2014]
Seasonality Modifies Methylation Profiles in He... [Published Plosone.org - Sep 12 2014]
Scientists revert human stem cells to pristine ... [Published Nanowerk - Sep 11 2014]
Crop improvement and resistance to pathogens be... [Published EurekAlert! - Sep 11 2014]
G9a co-suppresses LINE1 elements in spermatogonia [Published 7thSpace - Sep 11 2014]
Analysis of Tumor Suppressor Genes Based on Gen... [Published Plosone.org - Sep 10 2014]
G9a/GLP-dependent H3K9me2 patterning alters chr... [Published 7thSpace - Sep 10 2014]
This Researcher Hopes to Find a Way to Slow Aging [Published Slate Magazine - Sep 09 2014]
Internationally Acclaimed Scientist Named Co-Le... [Published Noodls - Sep 09 2014]
eMethylsorb: Electrochemical quantification of ... [Published RSC - Sep 09 2014]
Study uncovers different routes to problem beha... [Published Noodls - Sep 09 2014]
Role of Epigenetics in EBV Regulation and Patho... [Published General Medicine eJournal - Sep 09 2014]
Ikaros and RAG-2-Mediated Antisense Transcripti... [Published Plosone.org - Sep 08 2014]
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Blogs

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Reconfiguration of nucleosome-depleted regions ... [Published Genome Research current issue - Sep 02 2014]
It is well established that cancer-associated epigenetic repression occurs concomitant with CpG island hypermethylation and loss of nucleosomes at promoters, but the role of nucleosome occupancy and epigenetic reprogramming at distal regulatory elements ...
Scientists map the ‘editing marks’ on fly, worm... [Published WUSTL Science & Technology News - Aug 27 2014]
iStock and Creative CommonsD. melanogaster, the fruit fly, (top) has served for more than 100 years as a model for human biology, while the transparent worm C. elegans (bottom) is a comparative newcomer with a 40-year service record.   The genome ...
Scientists discover how ‘jumping genes’ help bl... [Published UCLA Newsroom - Aug 05 2014]
Black truffles have a syrupy sweet flavor and are highly prized in haute cuisine. A study by an international team of scientists sheds new light on their unique pattern of DNA methylation, a biochemical process. ...
The dynamics of DNA methylation fidelity during... [Published Genome Research current issue - Aug 01 2014]
The faithful transmission of DNA methylation patterns through cell divisions is essential for the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment of methylation fidelity, we implemented a genome-scale hairpin bisulfite ...
Nucleosome repositioning links DNA (de)methylat... [Published Genome Research current issue - Aug 01 2014]
During differentiation of embryonic stem cells, chromatin reorganizes to establish cell type-specific expression programs. Here, we have dissected the linkages between DNA methylation (5mC), hydroxymethylation (5hmC), nucleosome repositioning, and binding ...
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Press Releases

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Karyopharm Announces Initiation of a Phase 1 St... [Published GlobeNewswire: Acquisitions News - Apr 15 2014]
DBV Technologies and CEA conclude a scientific ... [Published GlobeNewswire: Advertising News - Apr 09 2014]
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