Publication: Ecancer Medicalscience

First reported Jul 31 2014 - Updated Aug 01 2014 - 1 reports

Study identifies rational drug combinations that may overcome mantle cell lymphoma resistance to ibrutinib

Genomic analyses of tumour and healthy tissue from patients with mantle cell lymphomas that fail to respond to treatment with the anticancer drug ibrutinib (Imbruvica) or initially respond but then stop responding and progress, provided explanations for ... [Published Ecancer Medicalscience - Jul 31 2014]
First reported Jul 31 2014 - Updated Jul 31 2014 - 1 reports

European Medicines Agency approves lenvatinib for accelerated assessment in radioiodine-refractory differentiated thyroid cancer

The European Medicines Agency (EMA) has approved the accelerated assessment of the investigational oral multiple receptor tyrosine kinase (RTK) inhibitor lenvatinib, for the treatment of patients with progressive radioiodine-refractory, differentiated ... [Published Ecancer Medicalscience - Jul 31 2014]
First reported Jul 31 2014 - Updated Jul 31 2014 - 1 reports

Cause of rare childhood cancer discovered

Scientists have made a breakthrough in understanding the cause of a rare childhood muscle cancer, called Rhabdomyosarcoma (RMS).The discovery could lead to the development of improved therapies to treat the disease and other types of cancer in the fu ... [Published Ecancer Medicalscience - Jul 31 2014]
First reported Jul 30 2014 - Updated Jul 31 2014 - 1 reports

Minor sub-clones of cancer cells drive tumour growth

by ecancer reporter Clare SansomTumours arise through an evolutionary process involving the multiplication of somatic cells that bear mutations in or epigenetic changes to their DNA.Until recently, it was thought that this process was a linear one involving ... [Published Ecancer Medicalscience - Jul 30 2014]
First reported Jul 30 2014 - Updated Jul 30 2014 - 1 reports

Research: Anaplastic thyroid cancer: multimodal treatment results

/ DOI: 10.3332/ecancer.2014.449Zaki Antonio Taissoun Aslan, Martín Granados-García, Kuauhyama Luna-Ortiz, Francisco Javier Guerrero-Huerta, Antonio Gómez-Pedraza, Silvio A Ñamendys-Silva, Abelardo Meneses-García and Juliana María Ordoñez-MosqueraBackground: ... [Published Ecancer Medicalscience - Jul 30 2014]
First reported Jul 29 2014 - Updated Jul 30 2014 - 1 reports

New treatment combination benefited patients with lung cancer resistant to EGFR inhibitors

A combination of the EGFR-targeted anticancer therapeutics afatinib (Gilotrif) and cetuximab (Erbitux) yielded clinical responses in 29 percent of patients who had lung cancer harbouring epidermal growth factor receptor (EGFR) mutations that had stopped ... [Published Ecancer Medicalscience - Jul 29 2014]
First reported Jul 29 2014 - Updated Jul 29 2014 - 1 reports

New study finds that stem cells are far more behaviourally diverse than previously thought

Biologists at the University of Sheffield’s Centre for Stem Cell Biology led by Professor Peter Andrews and engineers in the Complex Systems and Signal Processing Group led by Professor Daniel Coca have completed a landmark study of human pluripotent ... [Published Ecancer Medicalscience - Jul 29 2014]
First reported Jul 28 2014 - Updated Jul 28 2014 - 1 reports

New accurate epigenetic test could eliminate unnecessary repeat biopsies for prostate cancer

More than one million prostate biopsies are performed each year in the USA alone, including many repeat biopsies for fear of cancer missed.Therefore there is a need to develop diagnostic tests that will help avoid unnecessary repeat biopsies.Two independent ... [Published Ecancer Medicalscience - Jul 28 2014]
First reported Jul 25 2014 - Updated Jul 25 2014 - 1 reports

NICE recommends single does intrabeam radiotherapy for early breast cancer

An innovative new type of radiotherapy for breast cancer is set to be recommended for NHS patients in England under carefully controlled circumstances.The National Institute for Health and Care Excellence (NICE) has published draft guidance on the use ... [Published Ecancer Medicalscience - Jul 25 2014]
First reported Jul 25 2014 - Updated Jul 25 2014 - 1 reports

FDA approves idelalisib for the treatment of patients with relapsed chronic lymphocytic leukemia

The U.S. Food and Drug Administration (FDA) has approved idelalisib (Zydelig tablets, GileadSciences, Inc.) for the treatment of patients with relapsed chronic lymphocytic leukemia (CLL), in combination with rituximab, for whom rituximab alone would be ... [Published Ecancer Medicalscience - Jul 25 2014]
First reported Jul 24 2014 - Updated Jul 24 2014 - 1 reports

Research: Clinicopathologic subtypes and compromise of lymph nodes in patients with breast cancer

/ DOI: 10.3332/ecancer.2014.448ResearchB Jaime Jans, M Nicolás Escudero, B Dahiana Pulgar, C Francisco Acevedo, R César Sánchez and A Mauricio CamusBreast cancer (BC) is currently a heterogeneous disease with variations in clinical behaviour. Classification ... [Published Ecancer Medicalscience - Jul 24 2014]
First reported Jul 15 2014 - Updated Jul 16 2014 - 2 reports

Gene signature may predict breast cancer treatment response to tamoxifen

A gene signature identified using a new approach has the potential to be used in the clinic to predict which patients with of oestrogen receptor-positive breast cancer will benefit from tamoxifen therapy after surgery, according to data published in Cancer ... [Published Ecancer Medicalscience - Jul 15 2014]

Quotes

Dr Janet Shipley, leader of the Sarcoma Molecular Pathology team at The Institute of Cancer Research, London, said: "This study has promising therapeutic implications for targeting YAP1-driven pathways for the treatment of children with RMS. Through our analyses of human tumour samples, we were able to demonstrate that the findings in the mouse model are highly relevant to these cancers in humans."
"This epigenetic assay is a significant, independent predictor and has been shown to be the most valuable diagnostic aid of all evaluated risk factors in two independent trials" comments Alan W Partin, MD, PhD, of the James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore Maryla...
"One of the most exciting things about this project was the ability to work with experts in multiple fields to find new drug class and new mechanism that promises to actually help people with cancer" Liu said
...echolamines), a decrease in protective growth factor (neuregulin), and an increase in blood pressure," says lead author Dr Carrie Geisberg Lenneman. "This may contribute to why certain patients have a decline in heart function during chemotherapy treatment."

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All (58) | News (58) | Reports (0) | Blogs (0) | Audio/Video (0) | Fact Sheets (0) | Press Releases (0)
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European Medicines Agency approves lenvatinib f... [Published Ecancer Medicalscience - Jul 31 2014]
Study identifies rational drug combinations tha... [Published Ecancer Medicalscience - Jul 31 2014]
Cause of rare childhood cancer discovered [Published Ecancer Medicalscience - Jul 31 2014]
Minor sub-clones of cancer cells drive tumour g... [Published Ecancer Medicalscience - Jul 30 2014]
Research: Anaplastic thyroid cancer: multimodal... [Published Ecancer Medicalscience - Jul 30 2014]
New study finds that stem cells are far more be... [Published Ecancer Medicalscience - Jul 29 2014]
New treatment combination benefited patients wi... [Published Ecancer Medicalscience - Jul 29 2014]
New accurate epigenetic test could eliminate un... [Published Ecancer Medicalscience - Jul 28 2014]
FDA approves idelalisib for the treatment of pa... [Published Ecancer Medicalscience - Jul 25 2014]
NICE recommends single does intrabeam radiother... [Published Ecancer Medicalscience - Jul 25 2014]
Research: Clinicopathologic subtypes and compro... [Published Ecancer Medicalscience - Jul 24 2014]
Does cycling increase prostate cancer risk? [Published Ecancer Medicalscience - Jul 23 2014]
New genetic loci associated with breast cancer ... [Published Ecancer Medicalscience - Jul 22 2014]
Case Report: Spindle cell carcinoma of the tong... [Published Ecancer Medicalscience - Jul 22 2014]
Improving tumour radiation therapy: when basic ... [Published Ecancer Medicalscience - Jul 21 2014]
New combination drug controls tumour growth and... [Published Ecancer Medicalscience - Jul 21 2014]
Research: Clinical and epidemiological profile ... [Published Ecancer Medicalscience - Jul 18 2014]
Clinical Study: Sympathetic nervous system alte... [Published Ecancer Medicalscience - Jul 18 2014]
Keeping the heart in breast cancer treatment [Published Ecancer Medicalscience - Jul 17 2014]
New online video diary programme “Cancerstories... [Published Ecancer Medicalscience - Jul 17 2014]
Trastuzumab emtansine superior to physicians’ p... [Published Ecancer Medicalscience - Jul 16 2014]
Depressed men with prostate cancer are diagnose... [Published Ecancer Medicalscience - Jul 16 2014]
New insights into role of immune system in meta... [Published Ecancer Medicalscience - Jul 15 2014]
Gene signature may predict breast cancer treatm... [Published Ecancer Medicalscience - Jul 15 2014]
Tamoxifen gel effective when applied to breast,... [Published Ecancer Medicalscience - Jul 15 2014]
Testicular cancer rates are on the rise in youn... [Published Ecancer Medicalscience - Jul 14 2014]
Differences in treatment likely to be behind di... [Published Ecancer Medicalscience - Jul 14 2014]
RNA helicases DDX5 and DDX17 orchestrate gene e... [Published Ecancer Medicalscience - Jul 11 2014]
Policy: The Repurposing Drugs in Oncology (ReDO... [Published Ecancer Medicalscience - Jul 10 2014]
Clinical Study: Repurposing Drugs in Oncology (... [Published Ecancer Medicalscience - Jul 10 2014]
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