Tarceva

Type: Product
Name: Tarceva
First reported 28 mins ago - Updated 28 mins ago - 1 reports

Improved tyrosine kinase inhibitor (TKI) selectively activates in tumor tissue, minimizing side effects in patients

Share this article:A new strategy has been developed to reduce the often-serious side effects of tyrosine kinase inhibitors (TKIs), an important class of modern anticancer drugs. The novel drug is designed to restrict its activity with high selectivity ... [Published Chemotherapy Advisor - 28 mins ago]
First reported Oct 22 2014 - Updated Oct 22 2014 - 1 reports

For Patients With Advanced Non-Small Cell Lung Cancer (NSCLC), Dacomitinib Not Superior to Erlotinib

the Cancer Therapy Advisor take:According to a new study published in the journal The Lancet Oncology , researchers have found that dacomitinib was not superior to erlotinib in patients with advanced non-small cell lung cancer (NSCLC) or in patients with ... [Published Chemotherapy Advisor - Oct 22 2014]
First reported Oct 21 2014 - Updated Oct 21 2014 - 2 reports

Emerging Markets Earnings Roundup: Roche (Part 2)

Roche feels the heat still from Tarceva competition in China, but Japan regains luster as sales tax hit dims and diagnostics benefit as governments in emerging markets ramp up health care spending. ... [Published Health News Daily - Oct 21 2014]
First reported Oct 19 2014 - Updated Oct 19 2014 - 1 reports

New Treatment Strategies Emerge for Non-Small Cell Lung Cancer

Philippe Bishop, MDThe treatment of patients with non-small cell lung cancer (NSCLC) who harbor an actionable mutation in EGFR or ALK continues evolve, as clinical trials begin exploring next-generation agents and combination strategies.Two studies recently ... [Published OncLive - Oct 19 2014]
First reported Oct 19 2014 - Updated Oct 19 2014 - 1 reports

NCI Launches ALCHEMIST Precision Medicine Trials for Patients with Certain Types of Early Lung Cancer

Image ToolsThe National Cancer Institute has launched a series of trials called ALCHEMIST, designed to identify early-stage lung cancer patients with tumors that harbor certain uncommon genetic changes and evaluate whether drug treatments targeted against ... [Published Oncology Times - Oct 19 2014]
First reported Oct 16 2014 - Updated Oct 16 2014 - 1 reports

Epidermal Growth Factor Inhibition, a Novel Pathway to Prevent Chronic Allograft Injury

BackgroundChronic allograft injury remains a major problem in clinical kidney transplantation and different growth factors participate in its development. Epidermal growth factor (EGF) affects cell proliferation and mitogenesis through its tyrosine kinase ... [Published Transplantation - Oct 16 2014]
First reported Oct 14 2014 - Updated Oct 14 2014 - 1 reports

Tarceva Forecast

LONDON, Oct. 14, 2014 /PRNewswire/ -- The BCC Research Tarceva Forecast is a quantitative forecast model in an easily accessible Microsoft Excel spreadsheet, segmented by specific parameters.The introductory sample of the Tarceva Forecast Model was ... [Published PR Newswire: Entertainment & Media - Oct 14 2014]
First reported Oct 09 2014 - Updated Oct 09 2014 - 1 reports

Atypical response to erlotinib in a patient with metastatic lung adenocarcinoma: a case report

IntroductionTyrosine kinase inhibitors are widely prescribed in thoracic oncology and have excellent responses as a first-line treatment for locally advanced or metastatic lung cancer with epidermal growth factor receptor mutations. The side effects of ... [Published 7thSpace - Oct 09 2014]
First reported Oct 07 2014 - Updated Oct 07 2014 - 1 reports

Forum Post: ERLOTINIB (TARCEVA) - TREATMENT IN WALES

A group for anyone affected by lung cancer to get together, ask questions, share experiences and support each other.ERLOTINIB (TARCEVA) - TREATMENT IN WALESPosted by SCOTTIE B on7 Oct 2014 11:52 AMHi Everyone,After seeing an item on the One Show last ... [Published Macmillan Cancer Support - Oct 07 2014]
Entities: Tarceva, Wales, Drugs, Wrexham, Wirral
First reported Oct 02 2014 - Updated Oct 02 2014 - 2 reports

New trial results for advanced squamous cell carcinoma of the lung

News, Oct 2 2014.Phase III data from the LUX-Lung 8 trial, the first study to directly compare the efficacy of afatinib versus erlotinib patients with advanced squamous cell carcinoma (SCC) of the lung, demonstrated superior progression-free survival ... [Published GM Journal - Oct 02 2014]
First reported Sep 27 2014 - Updated Sep 28 2014 - 2 reports

SAPA - PR-LUX-LUNG-8-TRIAL

PR-LUX-LUNG-8-TRIALContributed by NAMPA / SAPA.SAPA PR -- LUX-LUNG 8 TRIAL MET IS PRIMARY ENDPOINTIssued by: Business WireAttention: Health EditorsFor immediate release:Head-to-head Phase III trial demonstrates superior progression-free survival for afatinib ... [Published Namibia Press Agency - Sep 27 2014]
First reported Sep 26 2014 - Updated Sep 27 2014 - 2 reports

Strategy to reduce side effects in modern cancer therapy -- ScienceDaily

The occurrence of severe side effects and the development of resistance are two of the biggest problems facing modern cancer therapy. Even the latest, highly targeted cancer drugs such as the tyrosine kinase inhibitors Tarceva(R) or Sutent(R) are affected ... [Published DailyMe.Com - Sep 27 2014]
Entities: Cancer, Strategy, Sutent, Tarceva

Quotes

...outcomes for patients with advanced lung cancer," said Natasha B Leighl, MD, MSc, co-chair of ASCO's Expert Panel that endorsed the guideline. "It describes the current evidence and helps oncologists and pathologists understand and put molecular testing into clinical practice."
"The guideline recommends that small tumor samples of other histologies, for which an adenocarcinoma component cannot be excluded because of sampling, can be considered for testing, particularly if clinical criteria are suggestive (eg, younger age, lack of smoking history)" write the ASCO authors
News editors obtained the following quote from the background information supplied by the inventors: "Germline and somatic mutations affecting various cell proliferation pathways are known to affect the development of cancer in patients. For example, the acquisition of somatic mutations that confer growth advantage on the cells possessing such mutations is considered an important factor in the emergence and progression of cancerous tumors. As a number of such mutations was identified, the therapies were developed that target the proteins encoded by the mutated genes, as well as the therapies targeting the signaling pathways in which these mutated genes are involved. As these targeted therapies were implemented into clinical practice, it was discovered that mutations conferring the resistance to the targeted therapies develop and accumulate in the patients' cancerous tumors, over time rendering the therapy ineffective and making it necessary to change the course of treatment."

More Content

All (142) | News (130) | Reports (0) | Blogs (10) | Audio/Video (0) | Fact Sheets (2) | Press Releases (0)
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Improved tyrosine kinase inhibitor (TKI) select... [Published Chemotherapy Advisor - 28 mins ago]
High EGFR Gene Copy Number in Triple-Negative B... [Published General Medicine eJournal - 7 hours ago]
A conversation with a cancer patient about pall... [Published Health Canal - Oct 23 2014]
Afatinib active against NSCLC nervous system me... [Published MedWire News - Oct 22 2014]
For Patients With Advanced Non-Small Cell Lung ... [Published Chemotherapy Advisor - Oct 22 2014]
Highmark Insurance Company Announces Coverage f... [Published Clinical Lab Products - Oct 21 2014]
Emerging Markets Earnings Roundup: Roche (Part 2) [Published Health News Daily - Oct 21 2014]
Emerging Markets Earnings Roundup: Roche (Part 2) [Published BioPortfolio - Oct 21 2014]
ASCO Endorses Lung Cancer Guidelines for Molecu... [Published Cancernetwork.com - Oct 20 2014]
Green Tea and Fighting Cancer [Published Examiner.com - Oct 20 2014]
New Treatment Strategies Emerge for Non-Small C... [Published OncLive - Oct 19 2014]
NCI Launches ALCHEMIST Precision Medicine Trial... [Published Oncology Times - Oct 19 2014]
Epidermal Growth Factor Inhibition, a Novel Pat... [Published Transplantation - Oct 16 2014]
Roche Holding's (RHHBY) CEO Severin Schwan on Q... [Published Seeking Alpha - Oct 16 2014]
Roche posts solid sales performance for first n... [Published Pharma Letter - Oct 16 2014]
Comment PanHER inhibition in EGFR wildtype nons... [Published BioPortfolio - Oct 16 2014]
Novel Approach of MALDI Drug Imaging, Immunohis... [Published Analytical Chemistry - Oct 16 2014]
Managing Resistance to Targeted Agents: The Fut... [Published The ASCO Post - Oct 15 2014]
Tarceva Forecast [Published PR Newswire: Entertainment & Media - Oct 14 2014]
ASCO Endorses CAP/IASLC/AMP Guideline on EGFR a... [Published American Society of Clinical Oncology - Oct 13 2014]
ASCO Endorses Guideline on EGFR and ALK Testing... [Published Oncology Times - Oct 13 2014]
ASCO: Molecular Testing for All Lung Adenocarci... [Published American Journal of Public Health - Oct 13 2014]
Forum Post: RE: Treatment Plan [Published Macmillan Cancer Support - Oct 13 2014]
Forum Post: RE: living in 3 months sections [Published Macmillan Cancer Support - Oct 13 2014]
Tarceva Forecast: New research released [Published Live-PR.com - Oct 10 2014]
Atypical response to erlotinib in a patient wit... [Published 7thSpace - Oct 09 2014]
Researchers Submit Patent Application, "EGFR Bl... [Published 4 Traders - Oct 08 2014]
Forum Post: ERLOTINIB (TARCEVA) - TREATMENT IN ... [Published Macmillan Cancer Support - Oct 07 2014]
Humanized AXL antibodies [Published PharmCast - Oct 07 2014]
ARIAD Gets Breakthrough Therapy Designation for... [Published Zacks.com - Oct 06 2014]
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Blogs

sort by: Date | Relevance
Tarceva Forecast [Published PR Newswire: Entertainment & Media - Oct 14 2014]
LONDON, Oct. 14, 2014 /PRNewswire/ -- The BCC Research Tarceva Forecast is a quantitative forecast model in an easily accessible Microsoft Excel spreadsheet, segmented by specific parameters.The introductory sample of the Tarceva Forecast Model was ...
Head-to-head Phase III trial demonstrates super... [Published PR Newswire: Health - Sep 29 2014]
RIDGEFIELD, Conn., Sept. 29, 2014 /PRNewswire/ -- Phase III data from Boehringer Ingelheim's LUX-Lung 8 trial, the first study to evaluate the superiority of afatinib versus erlotinib in patients with advanced squamous cell carcinoma (SCC) of the lung, ...
Head-to-head Phase III trial demonstrates super... [Published Business Wire Health News - Sep 27 2014]
INGELHEIM, Germany--(BUSINESS WIRE)--For Ex-US and Ex-UK Media Only Phase III data from Boehringer Ingelheim’s LUX-Lung 8 trial, the first study to directly compare the efficacy of two different targeted agents in patients with advanced squamous cell ...
Advancing medicine, layer by layer [Published MIT News feed - Jul 01 2014]
Personalized cancer treatments and better bone implants could grow from techniques demonstrated by graduate students Stephen W. Morton and Nisarg J. Shah, who are both working in chemical engineering professor Paula Hammond's lab at MIT. Morton's work ...
Tarceva Forecast [Published PR Newswire: Entertainment & Media - Jun 19 2014]
NEW YORK, June 19, 2014 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:Tarceva Forecasthttp://www.reportlinker.com/p02162048/Tarceva-Forecast.htmlThe BCC Research Tarceva Forecast is a quantitative ...
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