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extracellular

Type: Keyphrase

Name: extracellular

First reported 6 hours ago - Updated 6 hours ago - 1 reports

pH-Triggered Charge-Reversal Polypeptide Nanoparticles for Cisplatin Delivery: Preparation and In Vitro Evaluation

A series of pH-responsive random copolymer poly(l-glutamic acid-co-l-lysine) [P(Glu-co-Lys)] were synthesized through the ring-opening polymerization (ROP) of γ-benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and 3-benzyloxycarbonyl-l-lysine N-carboxyanhydride ... [Published Biomacromolecules - 6 hours ago]

Entities: Nanoparticle, cisplatin, In Vitro

First reported 9 hours ago - Updated 9 hours ago - 1 reports

Estimation of Ligand Efficacies of Metabotropic Glutamate Receptors from Conformational Forces Obtained from Molecular Dynamics Simulations

Group 1 metabotropic glutamate receptors (mGluR) are G-protein coupled receptors with a large bilobate extracellular ligand binding region (LBR) that resembles a Venus fly trap. Closing of this LBR in the presence of a ligand is associated with the activation ... [Published Journal of Chemical Information and Modeling - 9 hours ago]

Entities: Ligand, Receptor, agonist

First reported 21 hours ago - Updated 14 hours ago - 1 reports

Macrophages required for regeneration [Immunology]

The failure to replace damaged body parts in adult mammals results from a muted growth response and fibrotic scarring. Although infiltrating immune cells play a major role in determining the variable outcome of mammalian wound repair, little is known ... [Published PNAS - 21 hours ago]

Entities: macrophage, Immunology, Axolotl, Salamander, INFILTRATION

First reported May 20 2013 - Updated May 20 2013 - 1 reports

Dynamic Dosing Assay Relating Real-Time Respiration Responses of Staphylococcus aureus Biofilms to Changing Microchemical Conditions

Bacterial biofilms are a metabolically heterogeneous community of bacteria distributed in an extracellular matrix comprised primarily of hydrated polysaccharides. Effective inhibitory concentrations measured under planktonic conditions are not applicable ... [Published Analytical Chemistry - May 20 2013]

Entities: Respiration, Assay, Bacteria

First reported May 20 2013 - Updated May 20 2013 - 1 reports

Non-Local Interaction via Diffusible Resource Prevents Coexistence of Cooperators and Cheaters in a Lattice Model

by David Bruce Borenstein, Yigal Meir, Joshua W. Shaevitz, Ned S. WingreenMany cellular populations cooperate through the secretion of diffusible extracellular resources, such as digestive enzymes or virulence factors. Diffusion of these resources leads ... [Published Elites TV - May 20 2013]

Entities: Diffusion, David Bruce, Interaction, Attribution, extracellular

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Findings from University Medical Center Update Understanding of Aminoacyltransferases

(NewsRx) -- By a News Reporter-Staff News Editor at Proteomics Weekly -- Investigators publish new report on Enzymes and Coenzymes. According to news reporting out of Kiel, Germany, by NewsRx editors, research stated, "Extracellular kallikrein-related ... [Published NewsRX - May 17 2013]

Entities: Protease, protease inhibitor, Serine, Enzymes

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Engineering Functional Nanothin Multilayers on Food Packaging: Ice-Nucleating Polyethylene Films

Polyethylene is the most prevalent plastic and is commonly used as a packaging material. Despite its common use, there are not many studies on imparting functionalities to those films which can make them more desirable for frozen food packaging. Here, ... [Published Journal of Agricultural and Food Chemistry - May 17 2013]

Entities: Polyethylene, Hydrophilic, extracellular

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Studies from Department of Physiology Have Provided New Information about Blood Pressure

(NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Fresh data on Blood Pressure are presented in a new report. According to news reporting originating from Paris, France, by NewsRx correspondents, research stated, "Proteinase-activated ... [Published NewsRX - May 17 2013]

Entities: Physiology, Receptor, Trypsin

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Studies from University of Michigan Have Provided New Information about Tissue Engineering

(NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- A new study on Biotechnology is now available. According to news reporting from Ann Arbor, Michigan, by NewsRx journalists, research stated, "We hypothesize that intervertebral disc (IVD) ... [Published NewsRX - May 17 2013]

Entities: Tissue Engineering, University of Michigan, Oxygen, Hypoxia, extracellular

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Halozyme Therapeutics Inc (HALO) : Most Active Health Stock

Equitymarketreport.com is devoted to fetch you the most exclusive stocks in the market today. Apart from scanning the markets for the most underrated stocks. We propel those victors directly to your email inbox first ahead of the rest of the marketplace ... [Published SBWire - May 16 2013]

Entities: Halozyme Therapeutics Incorporated, Roche Holding AG, Intrexon Corp, ViroPharma Inc, extracellular

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Biological Chemistry: Reports from Ludwig-Maximilians-University Describe Recent Advances in Biological Chemistry

Today's Medical & Research NewsBiological Chemistry2013 MAY 16 -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Biological Chemistry. According to news reporting from Munich, Germany, by NewsRx journalists, ... [Published NewsRX - May 16 2013]

Entities: Chemistry, extracellular, Sodium

First reported May 15 2013 - Updated May 15 2013 - 1 reports

Extracellular matrix proteins of stem cell niches promote breast cancer metastasis

Home » Syndicated Content » ecancer reporter Peter Goodwin talks to Dr Thordur Oskarsson of the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) at IMPAKT 2013 in Brussels. They discuss how the extracellular matrix proteins ... [Published BioPortfolio - May 15 2013]

Entities: extracellular, Stem Cell, Metastasis, Protein, Breast Cancer

Quotes

...Moussa. "We reasoned that small doses—for these mice, an equivalent to 1% of the dose used in humans—would turn on just enough autophagy in neurons that the cells would clear malfunctioning proteins, and nothing else. We successfully tested this for several diseases models that have an accumulation of intracellular protein. It gets rid of alpha-synuclein and tau in a number of movement disorders, such as Parkinson's disease as well as Lewy body dementia."

Nilotinib Enhances Toxic Protein Removal from Parkinson's Disease Neurons [Published Biotech Daily - 8 hours ago]

...enrollment in TRAVERSE represents another important milestone for Pexa-Vec's development," said Philippe Archinard, Chairman and CEO of Transgene. "We expect top line data from the primary analysis of TRAVERSE in Q4 of this year. These data, together with data from other ongoing trials with Pexa-Vec, should enable us to determine the optimal phase 3 trial design."

Transgene Announces Completion of Enrollment in TRAVERSE, a Phase 2b Clinical Trial of Pexa-Vec f ... [Published FinanzNachrichten.de - 9 hours ago]

...another important milestone for Pexa-Vec development and we expect top-line data from the primary analysis by the end of the year," said Fischer. "We look forward to advancing Pexa-Vec into Phase 3 trials and the potential of developing a novel therapeutic option with meaningful efficacy."

Jennerex Announces Completion of Enrollment in Phase 2b Clinical Trial of Pexa-Vec for the Treatm ... [Published Market Wire - 9 hours ago]

Dr Mark Vaeck, CEO of Complix, comments: "Our recently generated data on Alphabodies, particularly CPABs, show the promise of our Alphabody platform to transform drug development as we know it today. Alphabodies represent a unique therapeutic class. Unlike currently available biologics or small molecule drugs, Alphabodies have the potential to target a broad and validated but untouched target universe of proteins that are located inside cells. The unprecedented versatility, stability and cell penetrating capacity of Alphabodies enables them to target these intracellular PPIs, which are known to play a key role in the initiation and progression of major diseases such as cancer, autoimmunity, CNS and metabolic diseases. We are confident that our Alphabody platform can create next-generation therapeutics that will make a real difference in the treatment of disease and ultimately to the life of patients."

Complix to Present at Upcoming BioEquity Europe 2013 [Published TickerTech.com - 14 hours ago]

More Content

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Therapeutic use of anti-CS1 antibodies [Published PharmCast - 2 hours ago]
pH-Triggered Charge-Reversal Polypeptide Nanopa... [Published Biomacromolecules - 6 hours ago]
Nilotinib Enhances Toxic Protein Removal from P... [Published Biotech Daily - 8 hours ago]
Estimation of Ligand Efficacies of Metabotropic... [Published Journal of Chemical Information and Modeling - 9 hours ago]
Transgene Announces Completion of Enrollment in... [Published FinanzNachrichten.de - 9 hours ago]
Jennerex Announces Completion of Enrollment in ... [Published Market Wire - 9 hours ago]
Acne Pharmacotherapy: A Review [Published U.S.Pharmacist - 10 hours ago]
Control of Myeloid Cell Trafficking in Resolution [Published Sexual Development - 14 hours ago]
Myeloid Cells in Traffic [Published Sexual Development - 14 hours ago]
Mycobacterium tuberculosis-Induced Neutrophil E... [Published Sexual Development - 14 hours ago]
Complix to Present at Upcoming BioEquity Europe... [Published TickerTech.com - 14 hours ago]
Complix to Present at Upcoming BioEquity Europe... [Published KATV - 14 hours ago]
Stimulating Myocardial Regeneration with Perios... [Published Elites TV - 17 hours ago]
Economic Dynamics: Researchers from Boston Univ... [Published NewsRX - 20 hours ago]
Macrophages required for regeneration [Immunology] [Published PNAS - 21 hours ago]
Circadian mCry1 expression in SCN [Neuroscience] [Published PNAS - 21 hours ago]
Construction of Tregs by targeting IL-2 and CTL... [Published PNAS - 21 hours ago]
Proteomic Analysis of Temperature Dependent Ext... [Published Journal of Proteome Research - 22 hours ago]
Humanized C-kit antibody [Published PharmCast - 23 hours ago]
Mechanism of Siglec-8–mediated cell death in IL... [Published Journal of Allergy and Clinical Immunology - May 20 2013]
Dynamic Dosing Assay Relating Real-Time Respir... [Published Analytical Chemistry - May 20 2013]
Gilead Sciences' Management Presents at the 201... [Published Seeking Alpha - May 20 2013]
Genetic Engineering Study Reveals Molecular Mec... [Published Biotech Daily - May 20 2013]
Endostatin, an angiogenesis inhibitor, ameliora... [Published Respiratory Research - May 20 2013]
Researchers examine how BRD4 contributes to sus... [Published News-Medical.Net - May 20 2013]
Team finds mechanism linking key inflammatory m... [Published EurekAlert! - May 20 2013]
Non-Local Interaction via Diffusible Resource P... [Published Elites TV - May 20 2013]
Inhibitory Neuron and Hippocampal Circuit Dysfu... [Published Elites TV - May 20 2013]
Toll-Like Receptor 4 Mediates Acute Lung Injury... [Published Elites TV - May 20 2013]
Dry Skin: Nourish From The Inside Out For Dewy,... [Published Rescu - May 20 2013]

Blogs

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Considering Anti-Amyloid Immunotherapy [Published Fight Aging! - May 15 2013] Amyloids are solid masses that form in tissues as a result of misfolded proteins. The amount of amyloid increases with age, perhaps due to a failure of mechanisms that keep the levels of damaged or misfolded proteins under control, and this is thought ...
Fight Aging! Newsletter, May 13th 2013 [Published Fight Aging! - May 12 2013] FIGHT AGING! NEWSLETTERMay 13th 2013 The Fight Aging! Newsletter is a weekly email containing news, opinions, and happenings for people interested in aging science and engineered longevity: making use of diet, lifestyle choices, technology, and proven ...
Comments on Rapamycin and Metformin [Published Fight Aging! - May 10 2013] Three of the better known efforts to create a drug that modestly slows the rate of aging are centered on the following items: Resveratrol analogs that target sirtuins Rapamycin analogs that target mTOR Metformin Of these, ways to manipulate the ...
Fight Aging! Newsletter, May 6th 2013 [Published Fight Aging! - May 05 2013] FIGHT AGING! NEWSLETTERMay 6th 2013 The Fight Aging! Newsletter is a weekly email containing news, opinions, and happenings for people interested in aging science and engineered longevity: making use of diet, lifestyle choices, technology, and proven ...
Recent Research Results from the Study of Naked... [Published Fight Aging! - May 03 2013] Naked mole rats are well studied by the aging research community: there are large colonies of naked mole rats in US laboratories, and a steady output of new papers on naked mole rat biology from numerous research groups. Their genome was sequenced ...

Press Releases

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ACell MatriStem® Technology Ranks Highest in Co... [Published PR Newswire: Health - May 15 2013]
Research and Markets: Interfering With the ECM-... [Published Business Wire Health News - Mar 27 2013]
Research and Markets: Fc Epsilon RI Signaling P... [Published Business Wire Health News - Mar 25 2013]
Vitro Biopharma Appoints Established Life Scien... [Published CisionWire - English - Feb 20 2013]
Vitro Biopharma Launches New Stem Cell Products... [Published CisionWire - English - Jan 22 2013]