flecainide

Type: Keyphrase

Name: flecainide

First reported May 21 2013 - Updated May 21 2013 - 1 reports

Comparison of electrophysiological data from human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to functional pre-clinical safety assays

AbstractAIM: Human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) are a potential source to develop assays for predictive electrophysiological safety screening. Published studies show that the relevant physiology and pharmacology exists, but ... [Published Toxicological Sciences - May 21 2013]

Entities: Assay, Ion Channel, Sodium, Cisapride

First reported Nov 29 2012 - Updated Nov 29 2012 - 1 reports

Coroner rules Caversham drowing was accidental

An 84-year-old man who drowned in the River Thames may have been suffering from blurred vision and dizziness caused by his heart medicine.Coroner Peter Bedford recorded a verdict of accidental death at the inquest of Peter Bell, of Silverthorne Drive ... [Published Reading Post - Nov 29 2012]

Entities: Peter Bell, flecainide, Peter Bedford

Quotes

"The pooled analyses represent an important body of evidence supporting MYRBETRIQ as a potential treatment option for OAB symptoms of urge urinary incontinence, urgency and urinary frequency" said Shontelle Dodson, PharmD, Senior Director, Astellas Scientific and Medical Affairs

Data on MYRBETRIQ® (mirabegron) as Treatment for Overactive Bladder Presented at AUA 2013 [Published OSIX News - May 07 2013]

...Transit was delayed in ten of these eleven subjects. The authors observed: "when there was delayed esophageal transit of tablets, the initial absorption of acetaminophen (measured as AUC over the first 60 min) was lower than that after normal esophageal transit of tablets. The peak plasma acetaminophen concentration was also lower and occurred 90 min later when transit was delayed. These kinetic changes decrease the effectiveness of acetaminophen as an analgesic." See K S Channer and C J Roberts, "Effect of Delayed Esophageal Transit on Acetaminophen Absorption" Clinical Pharmacology and Therapeutics 37, 72-76...

Solid dosage form that promotes reliable oral, esophageal and GI transit [Published PharmCast - Mar 14 2013]

The coroner rejected the idea Mr Bell wished to end his own life and said the far more likely explanation was the effects of the Flecainide meant he "found his way into the river and had not been able to recover"

Coroner rules Caversham drowing was accidental [Published Reading Post - Nov 29 2012]

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Comparison of electrophysiological data from hu... [Published Toxicological Sciences - May 21 2013]
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Data on MYRBETRIQ® (mirabegron) as Treatment fo... [Published OSIX News - May 07 2013]
Data on MYRBETRIQ (mirabegron) as Treatment for... [Published FinanzNachrichten.de - May 07 2013]
Solid dosage form that promotes reliable oral, ... [Published PharmCast - Mar 14 2013]
Coroner rules Caversham drowing was accidental [Published Reading Post - Nov 29 2012]
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