Intramolecular

Type: Keyphrase
Name: Intramolecular
First reported 10 hours ago - Updated 10 hours ago - 1 reports

Theory of Substituent Effects on the Regioselectivity of Di-π-methane Rearrangements of Dibenzobarrelenes

The regioselectivities of the di-π-methane rearrangements of unsymmetrically substituted dibenzobarrelenes have been explored with DFT (UM06-2X). Regioselectivity depends on the intramolecular hydrogen bonding and originates from specific stabilization ... [Published Organic Letters - 10 hours ago]
First reported Sep 18 2014 - Updated Sep 18 2014 - 1 reports

Nickel-Catalyzed Intramolecular [3 + 2 + 2] Cycloadditions of Alkylidenecyclopropanes. A Straightforward Entry to Fused 6,7,5-Tricyclic Systems

A highly diastereo- and chemoselective intramolecular nickel-catalyzed cycloaddition of alkene- and alkyne-tethered alkynylidenecyclopropanes is reported. The method constitutes the first fully intramolecular [3 + 2 + 2] alkylidenecyclopropropane cycloaddition ... [Published Organic Letters - Sep 18 2014]
First reported Sep 18 2014 - Updated Sep 18 2014 - 1 reports

Atom Transfer Radical Cyclization of Trichloroacetamides to Electron-Rich Acceptors Using Grubbs’ Catalysts: Synthesis of the Tricyclic Framework of FR901483

Intramolecular Kharasch-type additions of trichloroacetamides on anisole and enol acetates catalyzed by Grubbs’ ruthenium carbenes are described. This protocol provides access to highly functionalized 2-azaspiro[4.5]decanes, morphan compounds, and the ... [Published Journal of Organic Chemistry - Sep 18 2014]
First reported Sep 18 2014 - Updated Sep 18 2014 - 1 reports

Brönsted Acid-Mediated Intramolecular Cyclization of Biaryl Triazenes for the Synthesis of Fluorenes and 9,10-Dihydro-Phenanthrenes

The efficient synthesis of fluorenes from biaryl triazenes is successfully developed. Up to 27 examples of biaryl triazenes are converted into their corresponding fluorene derivatives in the presence of CF3COOH (4.0 equiv). Mechanism research indicates ... [Published Journal of Organic Chemistry - Sep 18 2014]
First reported Sep 18 2014 - Updated Sep 18 2014 - 1 reports

Patent Issued for Chiral Pyrrolidine Core Compounds En Route to Inhibitors of Nitric Oxide Synthase

By a News Reporter-Staff News Editor at Life Science Weekly -- From Alexandria, Virginia , NewsRx journalists report that a patent by the inventors Silverman , Richard B. ( Winnetka, IL ); Xue, Fengtian ( Baton Rouge, LA ), filed on March 4, 2013 , was ... [Published 4 Traders - Sep 18 2014]
First reported Sep 17 2014 - Updated Sep 17 2014 - 1 reports

Annulation Reactions of Allenyl Esters: An Approach to Bicyclic Diones and Medium-Sized Rings

A flexible approach to construct sterically congested bicyclo-alkenedione frameworks is reported. Under the action of potassium carbonate, α-sulphonyl cycloalkanones are added to functionalized allenyl esters, leading to a lactone intermediate that is ... [Published Journal of Organic Chemistry - Sep 17 2014]
First reported Sep 16 2014 - Updated Sep 16 2014 - 1 reports

Amidation of Esters with Amino Alcohols Using Organobase Catalysis

A catalytic protocol for the base-mediated amidation of unactivated esters with amino alcohol derivatives is reported. Investigations into mechanistic aspects of the process indicate that the reaction involves an initial transesterification, followed ... [Published Journal of Organic Chemistry - Sep 16 2014]
First reported Sep 13 2014 - Updated Sep 13 2014 - 1 reports

Benzhydrylamines via Base-Mediated Intramolecular sp3 C-Arylation of N-Benzyl-2-nitrobenzenesulfonamidesAdvanced Intermediates for the Synthesis of Nitrogenous Heterocycles

† Departmentof Organic Chemistry, Institute of Molecular and Translational Medicine,Faculty of Science, Palacký University , 17. Listopadu 12, 771 46 Olomouc, Czech Republic ‡ Departmentof Chemistry and Biochemistry, Universityof Notre Dame , 251 Nie ... [Published Journal of Combinatorial Chemistry - Sep 13 2014]
First reported Sep 11 2014 - Updated Sep 11 2014 - 1 reports

Direct Inter- and Intramolecular Addition of Amides to Arylalkenes Promoted by KOt-Bu/DMF

Direct addition of tetrahydroisoquinoline derived amides to arylalkenes has been achieved in the presence of KOt-Bu/DMF. Both intermolecular and intramolecular reactions could occur in good yields. α-Amido alkyl radicals are proposed to be generated under ... [Published Journal of Organic Chemistry - Sep 11 2014]
First reported Sep 09 2014 - Updated Sep 09 2014 - 1 reports

A Step-Economical Route to Fused 1,2,3-Triazoles via an Intramolecular 1,3-Dipolar Cycloaddition between a Nitrile and an in Situ Generated Aryldiazomethane

An intramolecular 1,3-dipolar cycloaddition strategy for rapid entry into triazole-fused heterocyclic compounds without recourse to the traditional Cu(1)-catalyzed azide–alkyne cycloadditions is described. Central to the strategy is the in situ generation ... [Published Journal of Organic Chemistry - Sep 09 2014]
First reported Sep 05 2014 - Updated Sep 05 2014 - 1 reports

Phosphine Oxide-Catalyzed Enantioselective Intramolecular Aldol Reaction via Regioselective Enolization of Unsymmetrical Diketones with Tetrachlorosilane

The phosphine oxide-catalyzed asymmetric intramolecular aldol reactions of diketones were investigated. The combination of tetrachlorosilane and a chiral phosphine oxide catalyst promoted the acetyl-selective enolization of diketones, and the subsequent ... [Published Organic Letters - Sep 05 2014]
First reported Sep 04 2014 - Updated Sep 04 2014 - 1 reports

[Cu]-Catalyzed Domino Sonogashira Coupling Followed by Intramolecular 5-exo-dig Cyclization: Synthesis of 1,3-Dihydro-2-benzofurans

An efficient [Cu]-catalyzed domino Sonogashira coupling of o-bromobenzyl tertiary alcohols with terminal aryl acetylenes followed by an intramolecular anti-5-exo-dig cyclization is presented. The terminal aryl acetylenes were identified as ideal coupling ... [Published Journal of Organic Chemistry - Sep 04 2014]

Quotes

News editors obtained the following quote from the background information supplied by the inventors: "Selective inhibition of the neuronal isozyme of nitric oxide synthase (nNOS) has attracted significant interest as a novel strategy in developing therapeutics for the treatment of neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and Huntington's disease. Efforts to design nNOS selective inhibitors include development of a stereospecific pyrrolidine-based inhibitor (1, FIG. 1), which showed great potency (K.sub.i=5 nM) and extremely high selectivity for nNOS over closely related isoforms, endothelial NOS (eNOS, 3800 fold) and inducible NOS (iNOS, 1200 fold). Animal tests demonstrated that 1 could lead to a remarkable reduction in neurological damage to rabbit fetuses under hypoxic conditions, making 1 a strong candidate as a new drug for the treatment of neurodegenerative diseases."
...According to news reporting originating in Bangalore India , by NewsRx journalists, research stated, "Ten new organometallic half-sandwich ruthenium complexes with heterocyclic ligands have been synthesized (H1-H10). The substituents on the ancillary heterocyclic ligands were varied to understand the effect of substitution on anticancer activity."
"X represents --(CH.sub.2).sub.nNH.sub.2, --(CH.sub.2).sub.nNHQ--, CH.dbd.CH--CH--NH.sub.2, CH.dbd.CH--CH--NHQ, CH.dbd.CH--C(.dbd.O)--NH--(CH.sub.2).sub.nNH.sub.2, CH.dbd.CH--C(.dbd.O)--NH--(CH.sub.2).sub.nNH.sub.2-Q, wherein n=2 to 18, or a nucleotide having a pyrimidine base, said nucleotide carrying an aminolinker at a 5-position of the pyrimidine base; and wherein Q represents an active moiety."

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Theory of Substituent Effects on the Regioselec... [Published Organic Letters - 10 hours ago]
Nickel-Catalyzed Intramolecular [3 + 2 + 2] Cyc... [Published Organic Letters - Sep 18 2014]
Atom Transfer Radical Cyclization of Trichloro... [Published Journal of Organic Chemistry - Sep 18 2014]
Brönsted Acid-Mediated Intramolecular Cycliza... [Published Journal of Organic Chemistry - Sep 18 2014]
Patent Issued for Chiral Pyrrolidine Core Compo... [Published 4 Traders - Sep 18 2014]
A conformational switch in collybistin determin... [Published EMBO Journal - Sep 17 2014]
Regulation of cargo-selective endocytosis by dy... [Published EMBO Journal - Sep 17 2014]
Cell death pre-mRNA-encoding DNA [Published PharmCast - Sep 17 2014]
Annulation Reactions of Allenyl Esters: An App... [Published Journal of Organic Chemistry - Sep 17 2014]
Amidation of Esters with Amino Alcohols Using ... [Published Journal of Organic Chemistry - Sep 16 2014]
Asymmetric Synthesis Continues to Advance [Published PharmTech.com - Sep 15 2014]
Platinum blue staining of cells grown in electr... [Published Bio Techniques - Sep 13 2014]
Benzhydrylamines via Base-Mediated Intramolecul... [Published Journal of Combinatorial Chemistry - Sep 13 2014]
Mechanistic Study of the Selectivity of Olefin... [Published Journal of Organic Chemistry - Sep 11 2014]
Indian Institute of Science Reports Findings in... [Published HispanicBusiness.com - Sep 11 2014]
Direct Inter- and Intramolecular Addition of A... [Published Journal of Organic Chemistry - Sep 11 2014]
Single-molecule correlated chemical probing of ... [Published PNAS - Sep 10 2014]
A Step-Economical Route to Fused 1,2,3-Triazol... [Published Journal of Organic Chemistry - Sep 09 2014]
The Effect of Mechano-stimuli on the Amorphous-... [Published RSC - Sep 09 2014]
Luminescent bi-metallic fluoroborate derivative... [Published RSC - Sep 09 2014]
Ruthenium-Catalyzed Cyclization of Aromatic Nit... [Published Organic Letters - Sep 09 2014]
One-Pot Sequential Organocatalytic Michael–Tis... [Published Journal of Organic Chemistry - Sep 08 2014]
Hyperuralones A and B, New Acylphloroglucinol D... [Published Organic Letters - Sep 08 2014]
2,3-Dihalo-1-propenes as Building Blocks in Cu(... [Published Organic Letters - Sep 05 2014]
Chemical Profiling of Jatropha Tissues under Di... [Published Plosone.org - Sep 05 2014]
Phosphine Oxide-Catalyzed Enantioselective Intr... [Published Organic Letters - Sep 05 2014]
Communication Routes in ARID Domains between Di... [Published Plosone.org - Sep 05 2014]
A New Method for Synthesis of Peptide Thioester... [Published Organic Letters - Sep 05 2014]
Methods for treating viral infection using IL-2... [Published PharmCast - Sep 05 2014]
Near-Infrared Silver Cluster Optically Signalin... [Published Analytical Chemistry - Sep 05 2014]
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Seeing and touching a single synthetic molecula... [Published the Foresight Institute - Aug 25 2014]
Schematic illustration for single-molecule motion capturing and manipulation of 1-nm sized synthetic molecular machine by optical microscopy using a bead probe. A large bead attached to the rotor part of the synthetic molecular bearing (double decker ...
SGS Informs on New EFSA Assessment on Risks of ... [Published PR.com Press Releases - Jan 31 2014]
Münich, Germany, January 31, 2014 --( PR.com )-- What is Aspartame? Aspartame is a low-calorie, intense artificial sweetener. It is a white, odorless powder, approximately 200 times sweeter than sugar. Aspartame is a dipeptide of L-phenylalanine methyl ...
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