Type: Keyphrase
Name: Intramolecular
First reported 39 mins ago - Updated 39 mins ago - 1 reports

Mechanistic Insight into Asymmetric N–H Insertion Cooperatively Catalyzed by a Dirhodium Compound and a Spiro Chiral Phosphoric Acid

The insertion of a carbenoid into an N–H bond of an amine cooperatively catalyzed by a dirhodium catalyst and a spiro chiral phosphoric acid has been investigated in detail using density functional theory methods. Calculations indicate that the reaction ... [Published Organometallics - 39 mins ago]
First reported 5 hours ago - Updated 5 hours ago - 1 reports

Engineering exceptionally strong oxygen superbases with 1,8-diazanaphthalene di-N-oxides

DFT calculations revealed that 1,8-diazanaphthalene di-N-oxides provide extraordinary oxygen superbases, whose gas-phase and acetonitrile basicities surpass those of classical naphthalene-based nitrogen proton sponges. Such high basicity is almost entirely ... [Published RSC - 5 hours ago]
First reported 18 hours ago - Updated 18 hours ago - 1 reports

Inactivation and Adsorption of Human Carbonic Anhydrase II by Nanoparticles

The enzymatic activity of human carbonic anhydrase II (HCAII) was studied in the presence of nanoparticles of different nature and charge. Negatively charged nanoparticles inhibit HCAII whereas no effect is seen for positively charged particles. The kinetic ... [Published Langmuir - 18 hours ago]
First reported 20 hours ago - Updated 20 hours ago - 1 reports

Indium-Mediated Asymmetric Intramolecular Allenylation of N-tert-Butanesulfinyl Imines: Efficient and Practical Access to Chiral 3-Allenyl-4-aminochromanes

An efficient method for the preparation of highly optically active 3-allenyl- and 3-vinyl-4-aminochromanes by In-mediated intramolecular cyclization has been developed. The synthetic utilities of the approach were demonstrated by the construction of various ... [Published Organic Letters - 20 hours ago]
First reported 23 hours ago - Updated 23 hours ago - 1 reports

Synthesis of Polyfluoroalkyl Aza-Polycyclic Aromatic Hydrocarbons Enabled by Addition of Perfluoroalkyl Radicals onto Vinyl Azides

Radical perfluoroalkylation of α-(biaryl-2-yl)vinyl azides is capable of supplying polyfluoroalkyl aza-polycyclic aromatic hydrocarbons (aza-PAHs). Commercially available Me3SiRf (Rf = CF3, C2F5, and C3F7) are employed as the sources of perfluoroalkyl ... [Published Organic Letters - 23 hours ago]
First reported 23 hours ago - Updated 23 hours ago - 1 reports

Mono- and Binuclear Copper(I) Complexes of Thionucleotide Analogues and Their Catalytic Activity on the Synthesis of Dihydrofurans

The reaction of copper(I) halides with 2-thiouracil (TUC), 6-methyl-2-thiouacil (MTUC), and 4-methyl-2-mercaptopyrimidine (MPMTH) in the presence of triphenylphosphine (tpp) in a 1:1:2 molar ratio results in a mixed-ligand copper(I) complex with the formulas ... [Published Inorganic Chemistry - 23 hours ago]
First reported 23 hours ago - Updated 23 hours ago - 1 reports

Rhodium(III)-Catalyzed Directed peri-C–H Alkenylation of Anthracene Derivatives

Rhodium(III)-catalyzed oxidative coupling reactions of anthracene-9-carboxylic acid derivatives with electron-deficient olefins are reported. A cationic rhodium(III) catalyst, in combination with a copper(II) oxidant, promotes selective monoalkenylation ... [Published Organic Letters - 23 hours ago]
First reported Jul 26 2014 - Updated Jul 26 2014 - 1 reports

Intramolecular Dehydro-Diels–Alder Reaction Affords Selective Entry to Arylnaphthalene or Aryldihydronaphthalene Lignans

Intramolecular dehydro-Diels–Alder (DDA) reactions are performed affording arylnaphthalene or aryldihydronaphthalene lactones selectively as determined by choice of reaction solvent. This constitutes the first report of an entirely selective formation ... [Published Organic Letters - Jul 26 2014]
First reported Jul 25 2014 - Updated Jul 25 2014 - 1 reports

Synthesis of Multisubstituted 2-Aminopyrroles/pyridines via Chemoselective Michael Addition/Intramolecular Cyclization Reaction

A facile and efficient synthetic strategy to construct polysubstituted 2-aminopyrroles/pyridines was developed via chemoselective Michael addition/intramolecular cyclization reaction under very mild conditions. It suggested that the chemoselectivity of ... [Published Organic Letters - Jul 25 2014]
First reported Jul 25 2014 - Updated Jul 25 2014 - 1 reports

How Tethers Control the Chemo- and Regioselectivities of Intramolecular Cycloadditions between Aryl-1-aza-2-azoniaallenes and Alkenes

Cationic 1-aza-2-azoniaallenes react intermolecularly with terminal alkenes to give 1,5-substituted (3 + 2)-cycloadducts, but intramolecular reactions lead to either 1,5- or 1,4-substituted (3 + 2)-cycloadducts or (4 + 2)-cycloadducts, depending on the ... [Published Organic Letters - Jul 25 2014]
First reported Jul 24 2014 - Updated Jul 24 2014 - 1 reports

Novel Synthesis of Right Segment of Solanoeclepin A

.01,6]decene skeleton of solanoeclepin A was synthesized through two key C–C bond forming processes; thus, a Hg(TFA)2-mediated oxymercuration followed an intramolecular aldol reaction to B and a SmI2-mediated cyclization of C between an aldehyde and an ... [Published Organic Letters - Jul 24 2014]
First reported Jul 23 2014 - Updated Jul 23 2014 - 1 reports

Palladium(0)-Catalyzed Intramolecular Decarboxylative Allylation of Ortho Nitrobenzoic Esters

A Pd/Ag bimetallic system has been developed for the decarboxylative allylation of ortho-nitrobenzoic esters in an intramolecular fashion. In contrast to the typical sp2–sp3 cross-coupling approach which requires air and moisture sensitive preformed organometallic ... [Published Organic Letters - Jul 23 2014]


Reporters obtained the following quote from the background information supplied by the inventors: "The elucidation of three-dimensional structures of protein complexes and protein protein interactions (PPIs) is one of the central goals in current biological research. Proteins bind to each other to carry out specific biological functions by forming various protein complexes (Hartwell et al., Nature 1999, 402, C47; Pereira-Leal, et al. Philosophical Transactions of the Royal Society B: Biological Sciences 2006, 361, 507). On average, proteins in vivo do not act alone, but rather act as part of a protein complex comprising 10 protein subunits in the cell (Sharan et al., Proc. Natl. Acad. Sci. U S A 2005, 102, 1974. The proteasome is a good example of a functional protein complex (King, R W ; Deshaies, R JJ Peters, J -M .; Kirschner , M W Science 1996, 274, 1652). The development of new reagents and methods for identification of binding partners and their interfaces is important for advancement in proteomic science."
Our news journalists obtained a quote from the research from the University of Paris , "Here, the bowl shape of resorcinarene allows such a coordination environment for ZnII complexes. A detailed NMR study with various carboxylic acids evidences size-, shape-, and, thus, regioselectivity for carboxylate coordination in the endo position, the exo position, or both. The coordination of diketonates unambiguously demonstrates the relative cis position of the two labile sites present in the tris(imidazole)zinc(II) bowl complex. An interesting intramolecular exchange process was also observed."

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Mechanistic Insight into Asymmetric N–H Insert... [Published Organometallics - 39 mins ago]
Engineering exceptionally strong oxygen superba... [Published RSC - 5 hours ago]
Inactivation and Adsorption of Human Carbonic A... [Published Langmuir - 18 hours ago]
Indium-Mediated Asymmetric Intramolecular Allen... [Published Organic Letters - 20 hours ago]
Mono- and Binuclear Copper(I) Complexes of Thio... [Published Inorganic Chemistry - 23 hours ago]
Rhodium(III)-Catalyzed Directed peri-C–H Alkeny... [Published Organic Letters - 23 hours ago]
Synthesis of Polyfluoroalkyl Aza-Polycyclic Aro... [Published Organic Letters - 23 hours ago]
Intramolecular Dehydro-Diels–Alder Reaction Af... [Published Organic Letters - Jul 26 2014]
Synthesis and Photophysical Studies of a Serie... [Published Journal of Organic Chemistry - Jul 25 2014]
Elucidation of Conformational States, Dynamics... [Published Journal of Chemical Information and Modeling - Jul 25 2014]
Synthesis of Multisubstituted 2-Aminopyrroles/p... [Published Organic Letters - Jul 25 2014]
TBHP-promoted sequential radical silylation and... [Published RSC - Jul 25 2014]
How Tethers Control the Chemo- and Regioselecti... [Published Organic Letters - Jul 25 2014]
Protonation Pattern, Tautomerism, Conformerism,... [Published Crystal Growth & Design - Jul 25 2014]
Efficient Synthesis of N-Alkylated α,β-Unsatur... [Published Organic Letters - Jul 25 2014]
Novel Synthesis of Right Segment of Solanoeclep... [Published Organic Letters - Jul 24 2014]
One-Pot Regioselective Synthesis of meta-Terph... [Published Journal of Organic Chemistry - Jul 24 2014]
Patent Issued for Clickable Cross-Linker [Published - Jul 24 2014]
Highly Efficient One-Dimensional ZnO Nanowire-... [Published ACS Applied Materials & Interfaces - Jul 24 2014]
New Supramolecular Research Study Findings Have... [Published - Jul 24 2014]
Rh(III)-Catalyzed Intramolecular Redox-Neutral ... [Published Organic Letters - Jul 23 2014]
Palladium(0)-Catalyzed Intramolecular Decarboxy... [Published Organic Letters - Jul 23 2014]
Impact of Inter- and Intramolecular Interaction... [Published Molecular Pharmaceutics - Jul 23 2014]
Annulated Isoxazoles via [3 + 2] Cycloaddition... [Published Journal of Organic Chemistry - Jul 23 2014]
Combinatorial biosynthesis of fungal polyketide... [Published PNAS - Jul 22 2014]
Tautomeric Preference and Conformation Locking ... [Published Crystal Growth & Design - Jul 22 2014]
Synthesis of 1-Arylcycloalkenamines by Intramo... [Published Organic Process Research & Development - Jul 21 2014]
Redox-Triggered Self-Assembly of Gadolinium-Ba... [Published Bioconjugate Chemistry - Jul 21 2014]
Total Synthesis of the Marine Pyridoacridine A... [Published Journal of Organic Chemistry - Jul 18 2014]
Macrocyclic Influences in CO2 Uptake and Stabi... [Published Organic Letters - Jul 18 2014]
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What If Total Syntheses Had Only 25 Steps to Wo... [Published In the Pipeline - Mar 17 2014]
Via the Baran lab's Twitter feed, here's a provocative article on whether total organic synthesis has a place in the modern world or not. One may wonder why this situation has passed undisputed for such a long time. Currently however, wide parts ...
SGS Informs on New EFSA Assessment on Risks of ... [Published Press Releases - Jan 31 2014]
Münich, Germany, January 31, 2014 --( )-- What is Aspartame? Aspartame is a low-calorie, intense artificial sweetener. It is a white, odorless powder, approximately 200 times sweeter than sugar. Aspartame is a dipeptide of L-phenylalanine methyl ...
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