Intramolecular

Type: Keyphrase

Name: Intramolecular

First reported 8 hours ago - Updated 8 hours ago - 1 reports

Total Synthesis of (−)-Hippodamine by Stereocontrolled Construction of Azaphenalene Skeleton Based on Extended One-Pot Asymmetric Azaelectrocyclization

The first asymmetric total synthesis of (−)-hippodamine has been accomplished via the concise construction of its azaphenalene core, which is featured by the 2,4,6-chiral piperidine synthesis based on one-pot asymmetric azaelectrocyclization in the partially ... [Published Organic Letters - 8 hours ago]

Entities: Synthesis, SKELETON, Construction

First reported 23 hours ago - Updated 23 hours ago - 1 reports

Observing tautomerization with transient 2D IR [Chemistry]

We provide a systematic characterization of the nanosecond ground-state lactam–lactim tautomerization of pyridone derivatives in aqueous solution under ambient conditions using temperature-jump transient 2D IR spectroscopy. Although electronic excited-state ... [Published PNAS - 23 hours ago]

Entities: Transient, Chemistry, Proton, nanosecond, Spectroscopy

First reported May 21 2013 - Updated May 21 2013 - 1 reports

Enantioselective Synthesis of Almorexant via Iridium-catalysed Intramolecular Allylic Amidation

Org. Biomol. Chem. , 2013, Accepted ManuscriptDOI : 10.1039/C3OB40655E, Paper Martin Fananas-Mastral, Johannes F. Teichert, Jose Antonio Fernandez-Salas, Dorus Heijnen, Ben L FeringaAn enantioselective synthesis of Almorexant, a potent antagonist of human ... [Published RSC - May 21 2013]

Entities: Intramolecular, Synthesis, AMIDE, Receptor

First reported May 20 2013 - Updated May 20 2013 - 1 reports

One-Pot Synthesis of 3-Hydroxyquinolin-2(1H)-ones from N-Phenylacetoacetamide via PhI(OCOCF3)2-Mediated α-Hydroxylation and H2SO4-Promoted Intramolecular Cyclization

A clean, one-pot synthesis of the biologically important 3-hydroxyquinolin-2(1H)-one compounds has been realized from the readily available N-phenylacetoacetamide derivatives through a PhI(OCOCF3)2-mediated α-hydroxylation and a H2SO4-promoted intramolecular ... [Published Journal of Organic Chemistry - May 20 2013]

Entities: Intramolecular, Synthesis, Tolerance

First reported May 20 2013 - Updated May 20 2013 - 1 reports

Chemical Biology: New Chemical Biology Study Results Reported from Free University

Today's Medical & Research NewsChemical Biology2013 MAY 20 -- By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Chemical Biology are presented in a new report. According to news originating from Berlin, Germany, by NewsRx correspondents, ... [Published NewsRX - May 20 2013]

Entities: Biology, Ligand, Chemical

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Tokyo Institute of Technology

Insight into cell survival

Catalytic centre in Atg3. In the absence of Atg12-Atg5, a catalytic Cys234 (magenta) is oriented away from Thr213 (orange) which is essential for Atg3 activity. When Atg3 interacts with Atg12-Atg5, Atg3 causes a conformational change, which reorients ... [Published Medical Xpress - May 17 2013]

Entities: Protein, Enzyme, Intramolecular, Tokyo Institute of Technology, Membrane

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Rhodium-Catalyzed Decarbonylative C–H Arylation of 2-Aryloxybenzoic Acids Leading to Dibenzofuran Derivatives

Rhodium-catalyzed intramolecular C–H arylation of 2-aryloxybenzoic acids proceeded accompanied by decarbonylation to give dibenzofuran derivatives in high yields. The present reaction is widely applicable to substrates bearing various functionalities ... [Published Organic Letters - May 17 2013]

Entities: Acids, Intramolecular, Substrate, Acid, yield

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Total Synthesis of Entecavir

Entecavir (BMS-200475) was synthesized from 4-trimethylsilyl-3-butyn-2-one and acrolein. The key features of its preparation are: (i) a stereoselective boron–aldol reaction to afford the acyclic carbon skeleton of the methylenecylopentane moiety; (ii) ... [Published Journal of Organic Chemistry - May 16 2013]

Entities: Entecavir, Synthesis, Acrolein, Intramolecular, Purine

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Self-Assembled Ln(III)4 (Ln = Eu, Gd, Dy, Ho, Yb) [2 × 2] Square Grids: a New Class of Lanthanide Cluster

Self-assembly of the Ln(III) ions (Ln = Eu, Gd, Dy, Ho, Yb) into square [2 × 2] grid-like arrays has been readily effected using simple, symmetric ditopic ligands based on a carbohydrazone core. The metal ions are connected via single atom bridges (e.g., ... [Published Inorganic Chemistry - May 16 2013]

Entities: Ion, Ligand, Intramolecular

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Cyclometalated Iridium Complexes of Bis(Aryl) Phosphine Ligands: Catalytic C–H/C–D Exchanges and C–C Coupling Reactions

This work details the synthesis and structural identification of a series of complexes of the (η5-C5Me5)Ir(III) unit coordinated to cyclometalated bis(aryl)phosphine ligands, PR′(Ar)2, for R′ = Me and Ar = 2,4,6-Me3C6H2, 1b; 2,6-Me2-4-OMe-C6H2, 1c; 2,6-Me2-4-F-C6H2, ... [Published Inorganic Chemistry - May 16 2013]

Entities: Phosphine, Chloride, Ligands, Intramolecular

First reported May 15 2013 - Updated May 15 2013 - 1 reports

Mechanism Elucidation of the cis–trans Isomerization of an Azole Ruthenium–Nitrosyl Complex and Its Osmium Counterpart

Synthesis and X-ray diffraction structures of cis and trans isomers of ruthenium and osmium metal complexes of general formulas (nBu4N)[cis-MCl4(NO)(Hind)], where M = Ru (1) and Os (3), and (nBu4N)[trans-MCl4(NO)(Hind)], where M = Ru (2) and Os (4) and ... [Published Inorganic Chemistry - May 15 2013]

Entities: Ruthenium, Osmium, Isomer, Intramolecular, Entropy

First reported May 15 2013 - Updated May 15 2013 - 1 reports

A Phosphine-Accelerated ArF–Chloride Bond Activation Process by Palladium

We present a mechanistic study demonstrating selective Arf–Cl bond activation preceded by η2 coordination of Pd(PEt3)2 to a C═C moiety of a partially fluorinated substrate. An intramolecular ring-walking process to activate the Arf–Cl bond is plausible, ... [Published Organometallics - May 15 2013]

Entities: Moiety, Intramolecular, Intermolecular, Fluorine, Chloride

Quotes

According to the news editors, the research concluded: "Our insights, particularly the possibility of intramolecular bivalent binding on a single ER monomer, may provide an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer."

Chemical Biology: New Chemical Biology Study Results Reported from Free University [Published NewsRX - May 20 2013]

"This study reveals the mechanism of the key reaction that drives membrane biogenesis during autophagy" explain Yoshinori Ohsumi, Machiko Sakoh-Nakatogawa and colleagues at Tokyo Institute of Technology, Institute of Microbial Chemistry and Hokkaido Un...

Insight into cell survival [Published Medical Xpress - May 17 2013]

"It is another object of the invention to utilize trehalose in an amount that is sufficient to stabilize a lyophilized BMP, at least one BMP, a biocompatible matrix, and additional excipients, said additional excipients selected from the group consisting of a buffer, a surfactant and mixtures thereof, to provide compositions and methods of preparing a lyophilized biocompatible matrix containing BMP that is stable and retains at least 60% of the biological activity upon rehydration, such that the rehydrated malleable product can be easily handled by the surgeon."

Patent Issued for Protein Stabilization Formulations [Published Equities.com - May 15 2013]

More Content

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Total Synthesis of (−)-Hippodamine by Stereocon... [Published Organic Letters - 8 hours ago]
Glutaredoxin contains GIY-YIG endonuclease moti... [Published PNAS - 23 hours ago]
Observing tautomerization with transient 2D IR ... [Published PNAS - 23 hours ago]
Enantioselective Synthesis of Almorexant via Ir... [Published RSC - May 21 2013]
One-Pot Synthesis of 3-Hydroxyquinolin-2(1H)-on... [Published Journal of Organic Chemistry - May 20 2013]
Chemical Biology: New Chemical Biology Study Re... [Published NewsRX - May 20 2013]
Insight into cell survival [Published Medical Xpress - May 17 2013]
Rhodium-Catalyzed Decarbonylative C–H Arylation... [Published Organic Letters - May 17 2013]
Total Synthesis of Entecavir [Published Journal of Organic Chemistry - May 16 2013]
Self-Assembled Ln(III)4 (Ln = Eu, Gd, Dy, Ho, ... [Published Inorganic Chemistry - May 16 2013]
Cyclometalated Iridium Complexes of Bis(Aryl) ... [Published Inorganic Chemistry - May 16 2013]
Mechanism Elucidation of the cis–trans Isomeri... [Published Inorganic Chemistry - May 15 2013]
Patent Issued for Protein Stabilization Formula... [Published Equities.com - May 15 2013]
A Phosphine-Accelerated ArF–Chloride Bond Acti... [Published Organometallics - May 15 2013]
Tandem Synthesis of Pyrroloacridones via [3 + 2... [Published Journal of Organic Chemistry - May 14 2013]
Synthesis of Differentially Substituted 2-Amino... [Published Journal of Organic Chemistry - May 14 2013]
A conical intersection model to explain aggrega... [Published RSC - May 14 2013]
Facile In-Situ Fabrication of Organic-Inorganic... [Published RSC - May 14 2013]
Synthesis of some fluorescent benzimidazole der... [Published RSC - May 10 2013]
Recent Advances in Catalytic Sequential Reactio... [Published Chemical Reviews - May 10 2013]
Palladium-Catalysed Aerobic Oxidative Heck-type... [Published RSC - May 09 2013]
Direct Observation of the Role of Lanthanides i... [Published RSC - May 09 2013]
Thermal Induced Intramolecular [2+2] Cycloaddit... [Published RSC - May 09 2013]
Characterization and Quantification of Mining-R... [Published Environmental Science & Technology - May 08 2013]
Computational Design of Two-Photon Fluorescent... [Published Inorganic Chemistry - May 08 2013]
Synthesis and Solvatochromic Fluorescence of Bi... [Published Organic Letters - May 08 2013]
Intramolecular Halogen-Halogen Bonds? [Published RSC - May 08 2013]
Synthesis, Structures, and Reactivity of Ruthen... [Published Organometallics - May 06 2013]
CuCN-Mediated Cascade Cyclization of 4-(2-Bromo... [Published Journal of Organic Chemistry - May 06 2013]
Interaction between Platinum Complexes and the... [Published Inorganic Chemistry - May 04 2013]