Intramolecular

Type: Keyphrase
Name: Intramolecular
First reported 4 hours ago - Updated 4 hours ago - 1 reports

Palladium-Catalyzed Intramolecular Oxidative Coupling Involving Double C(sp2)–H Bonds for the Synthesis of Annulated Biaryl Sultams

The palladium-catalyzed intramolecular oxidative coupling described herein involves a double C(sp2)–H bond functionalization in sulfonanilides, providing a workable access to biaryl sultams annulated into a six-membered ring that are otherwise difficult ... [Published Journal of Organic Chemistry - 4 hours ago]
First reported Aug 21 2014 - Updated Aug 21 2014 - 1 reports

Differential Sensitivity of Src-Family Kinases to Activation by SH3 Domain Displacement

by Jamie A. Moroco, Jodi K. Craigo, Roxana E. Iacob, Thomas E. Wales, John R. Engen, Thomas E. SmithgallSrc-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs ... [Published Plosone.org - Aug 21 2014]
First reported Aug 21 2014 - Updated Aug 21 2014 - 1 reports

Asymmetric Synthesis of Chiral Heterocyclic Amino Acids via the Alkylation of the Ni(II) Complex of Glycine and Alkyl Halides

An investigation into the reactivity profile of alkyl halides has led to the development of a new method for the asymmetric synthesis of chiral heterocyclic amino acids. This protocol involves the asymmetric alkylation of the Ni(II) complex of glycine ... [Published Journal of Organic Chemistry - Aug 21 2014]
First reported Aug 21 2014 - Updated Aug 21 2014 - 1 reports

An Artificial Tongue Fluorescent Sensor Array for Identification and Quantitation of Various Heavy Metal Ions

Herein, a small-molecule fluorescent sensor array for rapid identification of seven heavy metal ions was designed and synthesized, with its sensing mechanism mimicking that of a tongue. The photoinduced electron transfer and intramolecular charge transfer ... [Published Analytical Chemistry - Aug 21 2014]
First reported Aug 20 2014 - Updated Aug 20 2014 - 1 reports

Protonation induced shifting of electron-accepting centers in intramolecular charge transfer chromophores: a theoretical study

aDepartment of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576E-mail: msehc@nus.edu.sgcDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 ... [Published RSC - Aug 20 2014]
First reported Aug 20 2014 - Updated Aug 20 2014 - 1 reports

Uncommon cis Configuration of a Metal–Metal Bridging Noninnocent Nindigo Ligand

In contrast to several reported coordination compounds of trans-Nindigo ligands [Nindigo = indigo-bis(N-arylimine) = LH2] with one or two six-membered chelate rings involving one indole N and one extracyclic N for metal binding, the new diruthenium complex ... [Published Inorganic Chemistry - Aug 20 2014]
First reported Aug 19 2014 - Updated Aug 19 2014 - 1 reports

Bayesian Inference of Accurate Population Sizes and FRET Efficiencies from Single Diffusing Biomolecules

It is of significant biophysical interest to obtain accurate intramolecular distance information and population sizes from single-molecule Förster resonance energy transfer (smFRET) data obtained from biomolecules in solution. Experimental methods of ... [Published Analytical Chemistry - Aug 19 2014]
First reported Aug 18 2014 - Updated Aug 18 2014 - 1 reports

A general overview of the organocatalytic intramolecular aza-Michael reaction

The organocatalytic intramolecular aza-Michael reaction gives access to enantiomerically enriched nitrogen-containing heterocycles in a very simple manner. Enals, enones, conjugated esters and nitro olefins have been employed as Michael acceptors, while ... [Published RSC - Aug 18 2014]
First reported Aug 16 2014 - Updated Aug 16 2014 - 1 reports

Rh(II)/Brønsted Acid Cocatalyzed Intramolecular Trapping of Ammonium Ylides with Enones: Diastereoselective Synthesis of 2,2,3-Trisubstituted Indolines

Highly diastereoselective intramolecular trapping of ammonium ylides with enones has been developed through a Rh(II)/Brønsted acid cocatalytic strategy. This process allows rapid and efficient construction of N-unprotected polyfunctional 2,2,3-trisubstituted ... [Published Journal of Organic Chemistry - Aug 16 2014]
First reported Aug 15 2014 - Updated Aug 15 2014 - 1 reports

Progress toward the Total Synthesis of N-Methylwelwitindolinone B Isothiocyanate

Progress toward the welwitindolinone alkaloid N-methylwelwitindolinone B isothiocyanate is reported. A key reaction to synthesize the [4.3.1] bicycle embedded in the core of the molecule is a furan type 2 intramolecular Diels–Alder reaction with a tetrasubstituted ... [Published Organic Letters - Aug 15 2014]
First reported Aug 15 2014 - Updated Aug 15 2014 - 1 reports

Diisobutylaluminum Hydride Promoted Cyclization of o-(Trimethylsilylethynyl)styrenes to Indenes

The reaction of o-(trimethylsilylethynyl)styrenes with diisobutylaluminum hydride (DIBAL-H) provides 2-trimethylsilyl-1H-indenes efficiently. The cyclization mechanism involves regioselective hydroalumination of the alkynyl moiety, geometrical isomerization ... [Published Journal of Organic Chemistry - Aug 15 2014]
First reported Aug 12 2014 - Updated Aug 12 2014 - 1 reports

Ethylene Transposition: Ruthenium Hydride Catalyzed Intramolecular trans-Silylvinylation of Internal Alkynes

A highly selective intramolecular trans-silylvinylation of internal alkynes catalyzed by RuHCl(CO)(SIMes)(PPh3) has been accomplished. The use of methyl vinyl ketone as an additive increased the efficiency of this transformation. This process was used ... [Published Organic Letters - Aug 12 2014]

Quotes

...According to news reporting out of Waltham, Massachusetts , by NewsRx editors, research stated, "AZD5099 (compound 63) is an antibacterial agent that entered phase 1 clinical trials targeting infections caused by Gram-positive and fastidious Gram-negative bacteria. It was derived from previously reported pyrrolamide antibacterials and a fragment-based approach targeting the ATP binding site of bacterial type II topoisomerases."
"According to WO 2007/081486, the function of the defensins is to directly target and kill bacteria in the lumen to prevent them from invading the epithelial tissue. That is, the function of the defensins is purely as an anti-infective compound."

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Palladium-Catalyzed Intramolecular Oxidative C... [Published Journal of Organic Chemistry - 4 hours ago]
Differential Sensitivity of Src-Family Kinases ... [Published Plosone.org - Aug 21 2014]
Asymmetric Synthesis of Chiral Heterocyclic Am... [Published Journal of Organic Chemistry - Aug 21 2014]
An Artificial Tongue Fluorescent Sensor Array f... [Published Analytical Chemistry - Aug 21 2014]
Researchers at AstraZeneca Release New Data on ... [Published 4 Traders - Aug 20 2014]
Protonation induced shifting of electron-accept... [Published RSC - Aug 20 2014]
Uncommon cis Configuration of a Metal–Metal Br... [Published Inorganic Chemistry - Aug 20 2014]
Bayesian Inference of Accurate Population Sizes... [Published Analytical Chemistry - Aug 19 2014]
Characterization of Poly(N-isopropylacrylamide)... [Published RSC - Aug 18 2014]
A general overview of the organocatalytic intra... [Published RSC - Aug 18 2014]
Functionalized Lanthanide Coordination Polymers... [Published RSC - Aug 18 2014]
Rh(II)/Brønsted Acid Cocatalyzed Intramolecula... [Published Journal of Organic Chemistry - Aug 16 2014]
Progress toward the Total Synthesis of N-Methyl... [Published Organic Letters - Aug 15 2014]
Diisobutylaluminum Hydride Promoted Cyclizatio... [Published Journal of Organic Chemistry - Aug 15 2014]
Identification of Atomic-Level Mechanisms for G... [Published Accounts of Chemical Research - Aug 14 2014]
Novozymes A/S : Patent Application Titled "Oral... [Published 4 Traders - Aug 14 2014]
United Therapeutics Corp. v. Sandoz, Inc. (D.N.... [Published JD Supra - Aug 13 2014]
Ethylene Transposition: Ruthenium Hydride Catal... [Published Organic Letters - Aug 12 2014]
Synthesis of 4-Chalcogeno-1-aza-1,3-butadiene ... [Published Journal of Organic Chemistry - Aug 12 2014]
Structure–Property Relationship Study of Subst... [Published ACS Applied Materials & Interfaces - Aug 12 2014]
Formation, Structural Characterization, and Rea... [Published RSC - Aug 12 2014]
Distinguishable Zn(II) and Pb(II) template effe... [Published RSC - Aug 12 2014]
Structure and Dynamic Behavior of Phosphine Gol... [Published Organometallics - Aug 12 2014]
Preparation, Photophysical Characterization, an... [Published Langmuir - Aug 11 2014]
Synthesis of Pyrrolo-/Indolo[1,2-a]quinolines a... [Published Organic Letters - Aug 11 2014]
Solid-state photochromism and thermochromism of... [Published RSC - Aug 11 2014]
Human skin equivalents expressing exogenous pol... [Published PharmCast - Aug 11 2014]
Enantioselective Carbocycle Formation through I... [Published Organic Letters - Aug 09 2014]
Bioinspired Total Synthesis of Gymnothelignan N [Published Organic Letters - Aug 08 2014]
Ultrafast Z [rightward arrow] E photoisomerisat... [Published RSC - Aug 08 2014]
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What If Total Syntheses Had Only 25 Steps to Wo... [Published In the Pipeline - Mar 17 2014]
Via the Baran lab's Twitter feed, here's a provocative article on whether total organic synthesis has a place in the modern world or not. One may wonder why this situation has passed undisputed for such a long time. Currently however, wide parts ...
SGS Informs on New EFSA Assessment on Risks of ... [Published PR.com Press Releases - Jan 31 2014]
Münich, Germany, January 31, 2014 --( PR.com )-- What is Aspartame? Aspartame is a low-calorie, intense artificial sweetener. It is a white, odorless powder, approximately 200 times sweeter than sugar. Aspartame is a dipeptide of L-phenylalanine methyl ...
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