Intramolecular

Type: Keyphrase
Name: Intramolecular
First reported 2 hours ago - Updated 2 hours ago - 1 reports

Novel Synthesis of Right Segment of Solanoeclepin A

.01,6]decene skeleton of solanoeclepin A was synthesized through two key C–C bond forming processes; thus, a Hg(TFA)2-mediated oxymercuration followed an intramolecular aldol reaction to B and a SmI2-mediated cyclization of C between an aldehyde and an ... [Published Organic Letters - 2 hours ago]
First reported 2 hours ago - Updated 2 hours ago - 1 reports

One-Pot Regioselective Synthesis of meta-Terphenyls via [3 + 3] Annulation of Nitroallylic Acetates with Alkylidenemalononitriles

A highly efficient one-pot method has been developed for the synthesis of meta-terphenyls via a regioselective [3 + 3] annulation-elimination sequence involving Morita–Baylis–Hillman (MBH) acetates of nitroalkenes and alkylidenemalononitriles. The reaction ... [Published Journal of Organic Chemistry - 2 hours ago]
First reported 17 hours ago - Updated 17 hours ago - 1 reports

Patent Issued for Clickable Cross-Linker

By a News Reporter-Staff News Editor at Life Science Weekly -- According to news reporting originating from Alexandria, Virginia , by NewsRx journalists, a patent by the inventors Sohn , Chang Ho ( Pasadena, CA ); Beauchamp, Jesse L . ( La Canada Flintridge, ... [Published HispanicBusiness.com - 17 hours ago]
First reported 21 hours ago - Updated 21 hours ago - 1 reports

Palladium(0)-Catalyzed Intramolecular Decarboxylative Allylation of Ortho Nitrobenzoic Esters

A Pd/Ag bimetallic system has been developed for the decarboxylative allylation of ortho-nitrobenzoic esters in an intramolecular fashion. In contrast to the typical sp2–sp3 cross-coupling approach which requires air and moisture sensitive preformed organometallic ... [Published Organic Letters - 21 hours ago]
First reported 21 hours ago - Updated 21 hours ago - 1 reports

Rh(III)-Catalyzed Intramolecular Redox-Neutral or Oxidative Cyclization of Alkynes: Short, Efficient Synthesis of 3,4-Fused Indole Skeletons

A Rh(III)-catalyzed intramolecular redox-neutral or oxidative annulation of a tethered alkyne has been developed to efficiently construct 3,4-fused indoles via a C–H activation pathway. The advantages of this process are (1) ready availability of annulation ... [Published Organic Letters - 21 hours ago]
First reported Jul 23 2014 - Updated Jul 23 2014 - 1 reports

Impact of Inter- and Intramolecular Interactions on the Physical Stability of Indomethacin Dispersed in Acetylated Saccharides

Differential scanning calorimetry (DSC), broadband dielectric (BDS), and Fourier transform infrared (FTIR) spectroscopies as well as theoretical computations were applied to investigate inter- and intramolecular interactions between the active pharmaceutical ... [Published Molecular Pharmaceutics - Jul 23 2014]
First reported Jul 23 2014 - Updated Jul 23 2014 - 1 reports

Annulated Isoxazoles via [3 + 2] Cycloaddition of Alkenyl Bromides and Oximoyl Chlorides and Ag(I) Promoted Elimination

Substituted salicylaldehydes are converted to fused tetracyclic isoxazoles through a synthetic sequence incorporating substitution of 2-bromo-2-cyclohexen-1-ol, formation of an oxime function, conversion to an oximoyl chloride, intramolecular [3 + 2] ... [Published Journal of Organic Chemistry - Jul 23 2014]
First reported Jul 22 2014 - Updated Jul 22 2014 - 1 reports

Tautomeric Preference and Conformation Locking in Fenobam, Thiofenobam, and Their Analogues: The Decisive Role of Hydrogen Bond Hierarchy

The crystal and molecular structures of the potential antidepressant drug fenobam and its derivatives are examined in terms of the preferred form among the two possible tautomeric structures. In this study, chemical derivatization has been utilized as ... [Published Crystal Growth & Design - Jul 22 2014]
First reported Jul 21 2014 - Updated Jul 21 2014 - 1 reports

Synthesis of 1-Arylcycloalkenamines by Intramolecular Arylation of Lithiated Ureas

School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, U.K. Org. Process Res. Dev. , Article ASAP DOI: 10.1021/op500173q Publication Date (Web): June 27, 2014 Copyright © 2014 American Chemical Society AbstractThe deprotonation ... [Published Organic Process Research & Development - Jul 21 2014]
First reported Jul 21 2014 - Updated Jul 21 2014 - 1 reports

Redox-Triggered Self-Assembly of Gadolinium-Based MRI Probes for Sensing Reducing Environment

Controlled self-assembly of small molecule gadolinium (Gd) complexes into nanoparticles (GdNPs) is emerging as an effective approach to design activatable magnetic resonance imaging (MRI) probes and amplify the r1 relaxivity. Herein, we employ a reduction-controlled ... [Published Bioconjugate Chemistry - Jul 21 2014]
First reported Jul 18 2014 - Updated Jul 18 2014 - 1 reports

Total Synthesis of the Marine Pyridoacridine Alkaloid Demethyldeoxyamphimedine

A four-step total synthesis of the marine pyridoacridine alkaloid demethyldeoxyamphimedine (5) is presented. With an overall yield of 6.4%, this pentacyclic compound has been synthesized by utilizing only two commercial building blocks, ethyl nicotinate ... [Published Journal of Organic Chemistry - Jul 18 2014]
First reported Jul 18 2014 - Updated Jul 18 2014 - 1 reports

Macrocyclic Influences in CO2 Uptake and Stabilization

Two 24-member diamine-tetraamido macrocycles (R = H and CH3), readily synthesized in one or two steps, were found to react with CO2 rapidly and efficiently (100% conversion within 1 min at rt). The resulting carbamate formation was demonstrated by 1H, ... [Published Organic Letters - Jul 18 2014]

Quotes

Reporters obtained the following quote from the background information supplied by the inventors: "The elucidation of three-dimensional structures of protein complexes and protein protein interactions (PPIs) is one of the central goals in current biological research. Proteins bind to each other to carry out specific biological functions by forming various protein complexes (Hartwell et al., Nature 1999, 402, C47; Pereira-Leal, et al. Philosophical Transactions of the Royal Society B: Biological Sciences 2006, 361, 507). On average, proteins in vivo do not act alone, but rather act as part of a protein complex comprising 10 protein subunits in the cell (Sharan et al., Proc. Natl. Acad. Sci. U S A 2005, 102, 1974. The proteasome is a good example of a functional protein complex (King, R W ; Deshaies, R JJ Peters, J -M .; Kirschner , M W Science 1996, 274, 1652). The development of new reagents and methods for identification of binding partners and their interfaces is important for advancement in proteomic science."
Our news journalists obtained a quote from the research from the University of Paris , "Here, the bowl shape of resorcinarene allows such a coordination environment for ZnII complexes. A detailed NMR study with various carboxylic acids evidences size-, shape-, and, thus, regioselectivity for carboxylate coordination in the endo position, the exo position, or both. The coordination of diketonates unambiguously demonstrates the relative cis position of the two labile sites present in the tris(imidazole)zinc(II) bowl complex. An interesting intramolecular exchange process was also observed."

More Content

All (70) | News (68) | Reports (0) | Blogs (2) | Audio/Video (0) | Fact Sheets (0) | Press Releases (0)
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Novel Synthesis of Right Segment of Solanoeclep... [Published Organic Letters - 2 hours ago]
One-Pot Regioselective Synthesis of meta-Terph... [Published Journal of Organic Chemistry - 2 hours ago]
Patent Issued for Clickable Cross-Linker [Published HispanicBusiness.com - 17 hours ago]
Highly Efficient One-Dimensional ZnO Nanowire-... [Published ACS Applied Materials & Interfaces - 20 hours ago]
New Supramolecular Research Study Findings Have... [Published HispanicBusiness.com - 20 hours ago]
Rh(III)-Catalyzed Intramolecular Redox-Neutral ... [Published Organic Letters - 21 hours ago]
Palladium(0)-Catalyzed Intramolecular Decarboxy... [Published Organic Letters - 21 hours ago]
Impact of Inter- and Intramolecular Interaction... [Published Molecular Pharmaceutics - Jul 23 2014]
Annulated Isoxazoles via [3 + 2] Cycloaddition... [Published Journal of Organic Chemistry - Jul 23 2014]
Combinatorial biosynthesis of fungal polyketide... [Published PNAS - Jul 22 2014]
Tautomeric Preference and Conformation Locking ... [Published Crystal Growth & Design - Jul 22 2014]
Synthesis of 1-Arylcycloalkenamines by Intramo... [Published Organic Process Research & Development - Jul 21 2014]
Redox-Triggered Self-Assembly of Gadolinium-Ba... [Published Bioconjugate Chemistry - Jul 21 2014]
Total Synthesis of the Marine Pyridoacridine A... [Published Journal of Organic Chemistry - Jul 18 2014]
Macrocyclic Influences in CO2 Uptake and Stabi... [Published Organic Letters - Jul 18 2014]
Researchers at University of Melbourne Have Rep... [Published HispanicBusiness.com - Jul 17 2014]
New Biological Pigments Findings from King Abdu... [Published HispanicBusiness.com - Jul 16 2014]
Genetically Encoding an Electrophilic Amino Aci... [Published ACS Chemical Biology - Jul 16 2014]
Asymmetric Annulation of 3-Alkynylacrylaldehyde... [Published Journal of Organic Chemistry - Jul 16 2014]
An Intramolecular [2 + 2] Photocycloaddition A... [Published Journal of Organic Chemistry - Jul 16 2014]
Steric Congestion at, and Proximity to, a Ferro... [Published Inorganic Chemistry - Jul 16 2014]
Clickable cross-linker [Published Free Patents Online - Jul 15 2014]
Enantioselective Synthesis of Polycyclic Nitrog... [Published Organic Letters - Jul 15 2014]
Regioselective Synthesis of Fused Imidazo[1,2-... [Published Journal of Organic Chemistry - Jul 14 2014]
Supramolecular activation of a molecular photoc... [Published RSC - Jul 14 2014]
Methyl Ketone Oxime Esters as Nucleophilic Cou... [Published Journal of Organic Chemistry - Jul 11 2014]
Lots of Autoantibodies Equal Lupus? [Published General Medicine eJournal - Jul 11 2014]
Cell imaging using red fluorescent light-up pro... [Published RSC - Jul 10 2014]
Synthesis of a D-Ring Isomer of Galanthamine ... [Published Journal of Organic Chemistry - Jul 09 2014]
Photoinduced intramolecular charge transfer in ... [Published RSC - Jul 09 2014]
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What If Total Syntheses Had Only 25 Steps to Wo... [Published In the Pipeline - Mar 17 2014]
Via the Baran lab's Twitter feed, here's a provocative article on whether total organic synthesis has a place in the modern world or not. One may wonder why this situation has passed undisputed for such a long time. Currently however, wide parts ...
SGS Informs on New EFSA Assessment on Risks of ... [Published PR.com Press Releases - Jan 31 2014]
Münich, Germany, January 31, 2014 --( PR.com )-- What is Aspartame? Aspartame is a low-calorie, intense artificial sweetener. It is a white, odorless powder, approximately 200 times sweeter than sugar. Aspartame is a dipeptide of L-phenylalanine methyl ...
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