Publication: Journal of Medicinal Chemistry

First reported 17 hours ago - Updated 17 hours ago - 1 reports

Design, Synthesis, and Biological Evaluation of Aminoalkylindole Derivatives as Cannabinoid Receptor Ligands with Potential for Treatment of Alcohol Abuse

$ Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas 66045, United States‡ Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas ... [Published Journal of Medicinal Chemistry - 17 hours ago]

Entities: University of Kansas, Ligands, Medicinal Chemistry, University of Arkansas for Medical Sciences

First reported May 21 2013 - Updated May 21 2013 - 1 reports

Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

$ Division of Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States‡ Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill ... [Published Journal of Medicinal Chemistry - May 21 2013]

Entities: Hauptman-Woodward Medical Research Institute, Pyrimidine, Medicinal Chemistry

First reported May 20 2013 - Updated May 20 2013 - 1 reports

AstraZeneca PLC

Core Refinement toward Permeable β-Secretase (BACE-1) Inhibitors with Low hERG Activity

$ Department of Medicinal Chemistry, ‡Department of Neuroscience, and §Department of DMPK, AstraZeneca R&D Södertälje, SE-151 85, Södertälje, Sweden Discovery Sciences, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden ... [Published Journal of Medicinal Chemistry - May 20 2013]

Entities: Mölndal (Sweden), AstraZeneca PLC, Södertälje, Medicinal Chemistry, Research & Development

First reported May 17 2013 - Updated May 17 2013 - 1 reports

University of Oxford

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

$ Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, U.K.‡ Target Discovery Institute (TDI), University of Oxford, NDM Research Building, ... [Published Journal of Medicinal Chemistry - May 17 2013]

Entities: University of Oxford, Phosphorylation, Discovery Institute, Longwood (United States), Molecular Pharmacology

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Monitoring Conformational Changes in Peroxisome Proliferator-Activated Receptor α by a Genetically Encoded Photoamino Acid, Cross-Linking, and Mass Spectrometry

Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, D-06120 Halle/Saale, Germany ... [Published Journal of Medicinal Chemistry - May 17 2013]

Entities: Peroxisome, Pharmaceutical Chemistry, Mass Spectrometer

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase-1 (COX-1) Inhibitors

$ Dipartimento di Farmacia-Scienze del Farmaco, Universit$ degli Studi di Bari “A. Moro”, Via Orabona 4, 70125 Bari, Italy‡ Dipartimento di Farmacia, “Drug Discovery” Laboratory, Universit$ di Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy§Department ... [Published Journal of Medicinal Chemistry - May 17 2013]

Entities: Bari, Naples, Italy, Chieti (Italy)

First reported May 17 2013 - Updated May 17 2013 - 1 reports

Florida State University

Matrix Metalloproteinase Inhibitors Based on the 3-Mercaptopyrrolidine Core

Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States ... [Published Journal of Medicinal Chemistry - May 17 2013]

Entities: Molecular Biophysics, Florida State University, Biochemistry, Tallahassee (United States)

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Enantioselective Inhibition of Microbial Lipolytic Enzymes by Nonracemic Monocyclic Enolphosphonate Analogues of Cyclophostin

$ CNRS, Aix-Marseille Université, Enzymologie Interfaciale et Physiologie de la Lipolyse, UMR 7282, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France‡ Department of Chemistry and Biochemistry, University of Missouri−St. Louis, One University ... [Published Journal of Medicinal Chemistry - May 16 2013]

Entities: Enzymes, French National Centre for Scientific Research, University of Missouri, Biochemistry, Marseille

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Discovery of Novel STAT3 Small Molecule Inhibitors via in Silico Site-Directed Fragment-Based Drug Design

$ Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States‡ Center for Childhood Cancer, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, ... [Published Journal of Medicinal Chemistry - May 16 2013]

Entities: Ohio State University, Pharmacognosy, Drug Design, Medicinal Chemistry

First reported May 16 2013 - Updated May 16 2013 - 1 reports

CROSS: An Efficient Workflow for Reaction-Driven Rescaffolding and Side-Chain Optimization Using Robust Chemical Reactions and Available Reagents

$ Struct., Design & Informatics, R&D LGCR, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main, Germany‡ F2S IAIS PnS, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main, Germany Chemistry, R&D LGCR, ... [Published Journal of Medicinal Chemistry - May 16 2013]

Entities: Hochst (Germany), Sanofi SA, Germany

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo

$ Laboratorio di Chimica Bioinorganica, Polo Scientifico, Universit$ degli Studi di Firenze, Rm. 188 Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy‡ Department of Pharmacology, Faculty of Pharmacy, Bezmialem Vakif University, Vatan Caddesi, ... [Published Journal of Medicinal Chemistry - May 16 2013]

Entities: Florence, Sesto Fiorentino (Italy), Italy, Clinical Pharmacology, Pharmacology

First reported May 15 2013 - Updated May 15 2013 - 1 reports

Development and Therapeutic Implications of Selective Histone Deacetylase 6 Inhibitors

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, United States ... [Published Journal of Medicinal Chemistry - May 15 2013]

Entities: Pharmacognosy, histone deacetylase, Medicinal Chemistry, University of Illinois at Chicago

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Design, Synthesis, and Biological Evaluation o... [Published Journal of Medicinal Chemistry - 17 hours ago]
Design, Synthesis, and Molecular Modeling of N... [Published Journal of Medicinal Chemistry - May 21 2013]
Core Refinement toward Permeable β-Secretase (B... [Published Journal of Medicinal Chemistry - May 20 2013]
X-ray Crystal Structure of ERK5 (MAPK7) in Co... [Published Journal of Medicinal Chemistry - May 17 2013]
Monitoring Conformational Changes in Peroxisom... [Published Journal of Medicinal Chemistry - May 17 2013]
Synthesis, Pharmacological Characterization, a... [Published Journal of Medicinal Chemistry - May 17 2013]
Matrix Metalloproteinase Inhibitors Based on t... [Published Journal of Medicinal Chemistry - May 17 2013]
Enantioselective Inhibition of Microbial Lipol... [Published Journal of Medicinal Chemistry - May 16 2013]
Discovery of Novel STAT3 Small Molecule Inhibi... [Published Journal of Medicinal Chemistry - May 16 2013]
CROSS: An Efficient Workflow for Reaction-Driv... [Published Journal of Medicinal Chemistry - May 16 2013]
Xanthates and Trithiocarbonates Strongly Inhib... [Published Journal of Medicinal Chemistry - May 16 2013]
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