lysosome

Type: Keyphrase
Name: lysosome
First reported 1 hour ago - Updated 1 hour ago - 1 reports

Oligosaccharide-protein conjugates

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder ... [Published Free Patents Online - 1 hour ago]
First reported 10 hours ago - Updated 10 hours ago - 1 reports

Cancer cells tricked into gobbling up poison

Researchers have discovered a biological mechanism that causes colon cancer cells to ingest toxins and die without harming other tissue, paving the way for an immunotoxin therapy for colorectal cancer.They found that when they injected a monoclonal antibody ... [Published Gastroenterology Update - 10 hours ago]
First reported Sep 14 2014 - Updated Sep 14 2014 - 1 reports

Understanding Pathways and Pathophysiologic Implications of Autophagy

Autophagy functions in numerous critical ways, including in quality control, cell remodeling, and energy production. Understanding the molecular pathways of autophagy can result in understanding and treating neurodegenerative disorders, metabolic disorders, ... [Published American Journal of Managed Care - Sep 14 2014]
First reported Sep 11 2014 - Updated Sep 11 2014 - 1 reports

Calix[2]triazole[2]arene-Based Fluorescent Chemosensor for Probing the Copper Trafficking Pathway in Wilson's Disease

A pyrenyl-appended calix[2]triazole[2]arene displaying excellent selectivity for Cu2+ over other metal ions in pyrenyl excimer emission changes was synthesized. The binding mode with Cu2+ was supported through nuclear magnetic resonance (NMR) studies ... [Published RSC - Sep 11 2014]
First reported Sep 11 2014 - Updated Sep 11 2014 - 1 reports

Altered Surfactant Homeostasis and Alveolar Epithelial Cell Stress in Amiodarone-Induced Lung Fibrosis

AbstractAmiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects. Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may cause interstitial pneumonia as well as lung fibrosis. Apoptosis ... [Published Toxicological Sciences - Sep 11 2014]
First reported Sep 10 2014 - Updated Sep 10 2014 - 2 reports

Genzyme Announces Launch of "Expression of Hope III" Program to Build Awareness of Lysosomal Storage Disorders Through Works of Art

CAMBRIDGE, Mass.---- Genzyme, a Sanofi company, today announced the launch of Expression of Hope III, a global program of inspiration and awareness featuring works of art by the community of people affected by lysosomal storage disorders. ... [Published CNBC - Sep 10 2014]
First reported Sep 09 2014 - Updated Sep 09 2014 - 1 reports

Gobbling up Poison: a Method for Killing Colon Cancer

A new Immunotoxin works by getting shuttled into cancer cells, selectively destroying colon cancer, thanks to a quirk of biology(PHILADELPHIA) - These days, cancer researchers aim to design targeted and specific therapy - those that kill cancer but spare ... [Published Dotmed - Sep 09 2014]
First reported Sep 09 2014 - Updated Sep 09 2014 - 1 reports

Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors

Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal pH (pHL), or acidifying an abnormally elevated pHL, thus ... [Published Free Patents Online - Sep 09 2014]
First reported Sep 03 2014 - Updated Sep 03 2014 - 4 reports

Ultragenyx Announces Positive Data From Phase 1/2 Study Of RhGUS In MPS 7

Ultragenyx Pharmaceutical Inc. (RARE: Quote), a biopharmaceutical company focused on the development of novel products for rare and ultra-rare diseases, Wednesday announced the presentation of positive interim data from the Phase 1/2 study of recombinant ... [Published RTTNews.com - Sep 03 2014]
First reported Aug 26 2014 - Updated Aug 27 2014 - 2 reports

Attacking a rare disease at its source with gene therapy

PHILADELPHIA Treating the rare disease MPS I is a challenge. MPS I, caused by the deficiency of a key enzyme called IDUA, eventually leads to the abnormal accumulation of certain molecules and cell death.The two main treatments for MPS I are bone marrow ... [Published Bio-Medicine - Aug 26 2014]
First reported Aug 21 2014 - Updated Aug 21 2014 - 2 reports

Research and Markets: Global Lysosomal Storage Diseases Market 2014-2018: Key Vendors are Actelion Pharmaceuticals, …

DUBLIN--(BUSINESS WIRE)--Research and Markets ( http://www.researchandmarkets.com/research/5f7fvn/global_lysosomal ) has announced the addition of the "Global Lysosomal Storage Diseases Market 2014-2018" report to their offering.The Global Lysosomal ... [Published Yahoo! Finance - Aug 21 2014]
First reported Aug 18 2014 - Updated Aug 18 2014 - 2 reports

Global Lysosomal Storage Diseases Market 2014-2018: Key Vendors are Actelion, BioMarin, Genzyme and Shire

These deficiencies result in deficient enzymatic activity which, in turn, leads to accumulation of partially digested or undigested macromolecules inside the cell. The clinical manifestations of lysosomal storage diseases depend on the type of substrate ... [Published Indianapolis Business Journal - Aug 18 2014]

Quotes

...vitro through nucleic acid machinery that generally only allows linear DNA/RNA to be packaged through a portal channel," Liu tells Medical Xpress. "However, in vitro protein packaging is generally impossible, because for most viral nanoparticles there is no protein packaging machinery comparable to nucleic acid packaging machinery." While protein may be chemically cross-linked to the capsid inner surface, this is expected to lead to protein denaturation and loss of enzymatic act...
Reporters obtained the following quote from the background information supplied by the inventors: "Mammalian cathepsins are cysteine-type proteases involved in key steps of biological and pathological events. Cathepsins are considered tractable drug targets as it is feasible to inhibit enzymatic activity with small molecules and are therefore of interest to the pharmaceutical industry (Bromme, D (2001), `Papain-like cysteine proteases`, Curr Protoc Protein Sci, Chapter 21, Unit 21 2; Roberts, R (2005), `Lysosomal cysteine proteases: structure, function and inhibition of cathepsins`, Drug News Perspect, 18 (10), 605-14)."
...presents during childhood," said Paige Kaplan, MB, BCh, Section of Biochemical Genetics (Metabolic Diseases), Children's Hospital of Philadelphia. "It is important that children with this disease have access to a range of FDA-approved treatment options that are effective."

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All (219) | News (158) | Reports (0) | Blogs (56) | Audio/Video (1) | Fact Sheets (0) | Press Releases (3)
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Heme induces inflammasome activation [Immunolog... [Published PNAS - 26 mins ago]
Nanocontainers for nanocargo: Delivering genes ... [Published PhysOrg.com - 32 mins ago]
Oligosaccharide-protein conjugates [Published Free Patents Online - 1 hour ago]
Cancer cells tricked into gobbling up poison [Published Gastroenterology Update - 10 hours ago]
Understanding Pathways and Pathophysiologic Imp... [Published American Journal of Managed Care - Sep 14 2014]
Considering Intracellular Amyloid Beta in Alzhe... [Published Fight Aging! - Sep 12 2014]
Unique Antibody Responses to Malondialdehyde-Ac... [Published Plosone.org - Sep 11 2014]
PiZ Mouse Liver Accumulates Polyubiquitin Conju... [Published Plosone.org - Sep 11 2014]
Calix[2]triazole[2]arene-Based Fluorescent Chem... [Published RSC - Sep 11 2014]
Altered Surfactant Homeostasis and Alveolar Epi... [Published Toxicological Sciences - Sep 11 2014]
Patent Issued for Azetidine Derivatives [Published 4 Traders - Sep 11 2014]
Sangamo Biosciences' (SGMO) CEO Edward Lanphier... [Published Seeking Alpha - Sep 10 2014]
The urinary proteome and metabonome differ from... [Published Kidney International - Sep 10 2014]
Genzyme Announces Launch of "Expression of Hope... [Published CNBC - Sep 10 2014]
Genzyme Announces Launch of “Expression of Hope... [Published Genzyme Press Release - Sep 10 2014]
Genzyme Announces Launch of “Expression of Hope... [Published Business Wire Health News - Sep 10 2014]
Pfizer and Protalix BioTherapeutics Announce FD... [Published Pharmacy Choice - Sep 10 2014]
Sangamo BioSciences Announces Target Date For F... [Published Pettinga Financial Advisors - Sep 10 2014]
Novel Gene Therapy Payment Model Proposed [Published Genetic Engineering News - Sep 10 2014]
BioMarin Pharmaceutical Has Returned 10.6% Sinc... [Published Comtex SmarTrend - Sep 09 2014]
Gobbling up Poison: a Method for Killing Colon ... [Published Dotmed - Sep 09 2014]
Mitochondrial localization of the OAS1 p46 isof... [Published BMC - Sep 09 2014]
Method for treatment of macular degeneration by... [Published Free Patents Online - Sep 09 2014]
'Fingerprinting' cell metabolism points toward ... [Published PhysOrg.com - Sep 08 2014]
Poison As Cancer Treatment: Immunotoxins Derive... [Published Medical Daily - Sep 08 2014]
Gobbling up poison: A method for killing colon ... [Published Medical Xpress - Sep 08 2014]
Role of Vitamin C & Multivitamin Diets for Enha... [Published The Fish Site - Sep 08 2014]
Bacteria engage in a hazardous hide-and-seek [Published Health Canal - Sep 06 2014]
100 rise to Ice Bucket Challenge [Published New Straits Times - Sep 06 2014]
First Long-Term Study of Children with Infantil... [Published Neurology Today - Sep 05 2014]
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Considering Intracellular Amyloid Beta in Alzhe... [Published Fight Aging! - Sep 12 2014]
There is a growing diversity of views in the Alzheimer's research community regarding mechanisms and future directions, which is probably to be expected given the slow path to results on the consensus approach of removing amyloid β . Here is a representative ...
Genzyme Announces Launch of “Expression of Hope... [Published Business Wire Health News - Sep 10 2014]
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Genzyme announces the launch of Expression of Hope III, a global program of inspiration and awareness featuring works of art by the community of people affected by lysosomal storage disorders (LSD). ...
Cognitive Nanorobots for Pathology Resoulution ... [Published Broader Perspective - Sep 02 2014]
One way to think of cognitive nanorobots is as a subset of medical nanorobots, meaning nanorobots for use in the body related to medical purposes, in this case, neural processes. Nanorobots are tiny computing machines at the nanoscale that can perform ...
Global Lysosomal Storage Diseases Market 2014-2... [Published PR Newswire: General Business - Aug 18 2014]
DUBLIN, Aug. 18, 2014 /PRNewswire/ -- Research and Markets has announced the addition of the "Global Lysosomal Storage Diseases Market 2014-2018" report to their offering. The term lysosomal storage diseases refers to a group of rare inherited disorders ...
Working Towards a Way to Clear Cytomegalovirus [Published Fight Aging! - Aug 14 2014]
Like other herpesviruses , cytomegalovirus (CMV) cannot be effectively naturally cleared from the body as it has evolved the means to hide from the immune system . It is harmless for most people in the short term, but over the long term it causes ...
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Magnetically treated nanoparticles help tumour ... [Published Reuters Video: Technology - Jul 07 2014]
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Genzyme Announces Launch of “Expression of Hope... [Published Genzyme Press Release - Sep 10 2014]
Amicus Therapeutics Analyst Report; Solid Pipel... [Published Financial Services - Jul 07 2014]
BioMarin Doses First Patient in Phase 3 INSPIRE... [Published GlobeNewswire: Acquisitions News - May 27 2014]
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