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Medicinal Chemistry

Type: Keyphrase

Name: Medicinal Chemistry

First reported 7 hours ago - Updated 4 hours ago - 1 reports

Lund University

Breakthrough on Huntington’s disease

Researchers at Lund University have succeeded in preventing very early symptoms of Huntington’s disease, depression and anxiety, by deactivating the mutated huntingtin protein in the brains of mice. We are the first to show that it is possible to prevent ... [Published Health Canal - 7 hours ago]

Entities: Huntington's Disease, hypothalamus, Lund University, Mutation

First reported 21 hours ago - Updated 21 hours ago - 1 reports

University of Kansas

Design, Synthesis, and Biological Evaluation of Aminoalkylindole Derivatives as Cannabinoid Receptor Ligands with Potential for Treatment of Alcohol Abuse

$ Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas 66045, United States‡ Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas ... [Published Journal of Medicinal Chemistry - 21 hours ago]

Entities: University of Kansas, Ligands, Medicinal Chemistry, University of Arkansas for Medical Sciences

First reported May 22 2013 - Updated May 22 2013 - 1 reports

Studies in the Area of Medicinal Chemistry Reported from Mal. . .

Studies in the Area of Medicinal Chemistry Reported from Malaghan Institute of Medical ResearchMedicinal ChemistryNewsRx.comBy a News Reporter-Staff News Editor at Hematology Week -- Investigators publish new report on Medicinal Chemistry. According to ... [Published Equities.com - May 22 2013]

Entities: Medicinal Chemistry, Oxidation-Reduction, intracellular

First reported May 22 2013 - Updated May 22 2013 - 1 reports

Array BioPharma Inc

Researchers from Array BioPharma Detail Findings in Medicina. . .

Researchers from Array BioPharma Detail Findings in Medicinal ChemistryMedicinal ChemistryNewsRx.comBy a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Medicinal Chemistry have been published. According to news reporting ... [Published Equities.com - May 22 2013]

Entities: Array BioPharma Inc, Medicinal Chemistry, cerebrospinal fluid, Alzheimer's Disease

First reported May 22 2013 - Updated May 22 2013 - 2 reports

Roche Holding AG

Recent Research from F. Hoffmann-La Roche Highlight Findings. . .

Recent Research from F. Hoffmann-La Roche Highlight Findings in Medicinal ChemistryMedicinal ChemistryNewsRx.comBy a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Medicinal Chemistry is the subject of a report. According ... [Published Equities.com - May 22 2013]

Entities: Medicinal Chemistry, Roche Holding AG, Nutley (United States)

First reported May 22 2013 - Updated May 22 2013 - 1 reports

Researchers at F. Hoffmann-La Roche Report New Data on Diabe. . .

Researchers at F. Hoffmann-La Roche Report New Data on DiabetesDiabetesNewsRx.comBy a News Reporter-Staff News Editor at Diabetes Week -- Research findings on Diabetes are discussed in a new report. According to news reporting originating from Nutley, ... [Published Equities.com - May 22 2013]

Entities: Roche Holding AG, Nutley (United States), Medicinal Chemistry, Diabetes

First reported May 21 2013 - Updated May 21 2013 - 1 reports

Chuck Norris

Chuck Norris and Gena Norris Named As MAX International, L.L.C. World Ambassadors

/PRNewswire/ -- MAX International, L.L.C. (www.max.com/chuck) announces that Chuck Norris and his wife Gena Norris will serve as media campaign spokespersons and worldwide ambassadors for the company's health and sports nutraceutical products.(Photo: ... [Published FinanzNachrichten.de - May 21 2013]

Entities: Chuck Norris, glutathione, Gena

First reported May 21 2013 - Updated May 21 2013 - 1 reports

Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

$ Division of Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States‡ Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill ... [Published Journal of Medicinal Chemistry - May 21 2013]

Entities: Hauptman-Woodward Medical Research Institute, Pyrimidine, Medicinal Chemistry

First reported May 20 2013 - Updated May 20 2013 - 1 reports

Core Refinement toward Permeable β-Secretase (BACE-1) Inhibitors with Low hERG Activity

$ Department of Medicinal Chemistry, ‡Department of Neuroscience, and §Department of DMPK, AstraZeneca R&D Södertälje, SE-151 85, Södertälje, Sweden Discovery Sciences, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden ... [Published Journal of Medicinal Chemistry - May 20 2013]

Entities: Mölndal (Sweden), AstraZeneca PLC, Södertälje, Medicinal Chemistry, Research & Development

First reported May 20 2013 - Updated May 20 2013 - 1 reports

Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting

4 minutes ago, 7:08am (ET) 05/20/2013 Federal RegisterPursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting.The meeting will be closed to the public in accordance with ... [Published Zecco - May 20 2013]

Entities: National Institute of Child Health, Eunice Kennedy Shriver, National Institute of Child Health and Human De..., Federal

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Discovery of Novel STAT3 Small Molecule Inhibitors via in Silico Site-Directed Fragment-Based Drug Design

$ Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States‡ Center for Childhood Cancer, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, ... [Published Journal of Medicinal Chemistry - May 16 2013]

Entities: Ohio State University, Pharmacognosy, Drug Design, Medicinal Chemistry

First reported May 16 2013 - Updated May 16 2013 - 1 reports

Assistant / Associate / Full Professor in Pharmaceutical Sciences - College of Pharmacy

Assistant/Associate/Full Professor in Pharmaceutical Sciences – College of PharmacyUniversity of New EnglandPortland, METhe University of New England (UNE) College of Pharmacy is seeking a dynamic and creative tenure-track faculty member to join the Department ... [Published Molecular Systems Biology - May 16 2013]

Entities: University of New England, Proteomics, Pharmacokinetics, Molecular Biology

Quotes

In introducing his award, Heidi Hamm, Ph D , chair of Pharmacology on scholarly leave of absence this year, said, "Craig's role here at Vanderbilt has been nothing short of transformative ? He led the chemistry effort in the neuroscience drug discovery program that allowed four novel programs to advance to the clinical candidate stage in 2011, and three of which will be in phase 1 clinical trials this year."

2013 Academic Enterprise Faculty AwardsMay 23, 2013 [Published Noodls - 39 mins ago]

Our news journalists obtained a quote from the research from the Malaghan Institute of Medical Research, "We established that quaternary ammonium salt moieties carrying highly hindered, positive electronic charges located to the plasma membrane. A ten-carbon chain linked to these moieties was effective at positioning the redox-active ubiquinone-like function within the lipid bilayer to disrupt tPMET in human leukemic cells (IC50 9 1 M). TPMET inhibition alone was not sufficient to induce significant cell death, but positively charged compounds could also enter the cell and disrupt intracellular redox balance, distinct from their effects on mitochondrial electron transport. The synergistic effect of tPMET inhibition plus intracellular redox disruption gave strong antiproliferative activity (IC50 2 0.2 M)."

Studies in the Area of Medicinal Chemistry Reported from Mal. . . [Published Equities.com - May 22 2013]

According to the news reporters, the research concluded: "Optimization of brain exposure led to the discovery of -50 which reduced CSF A in rodents and in monkey."

Researchers from Array BioPharma Detail Findings in Medicina. . . [Published Equities.com - May 22 2013]

According to the news editors, the research concluded: "Compounds bearing this conformation participated in a favorable hydrophobic interaction with a cysteine residue in the JAK3 binding pocket, which imparted high selectivity versus the kinome and improved selectivity within the JAK family."

Recent Research from F. Hoffmann-La Roche Highlight Findings. . . [Published Equities.com - May 22 2013]

More Content

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2013 Academic Enterprise Faculty AwardsMay 23, ... [Published Noodls - 39 mins ago]
Breakthrough on Huntington’s disease [Published Health Canal - 7 hours ago]
Design, Synthesis, and Biological Evaluation o... [Published Journal of Medicinal Chemistry - 21 hours ago]
Studies in the Area of Medicinal Chemistry Repo... [Published Equities.com - May 22 2013]
Researchers from Array BioPharma Detail Finding... [Published Equities.com - May 22 2013]
Recent Research from F. Hoffmann-La Roche Highl... [Published Equities.com - May 22 2013]
Findings on Medicinal Chemistry Discussed by In... [Published Equities.com - May 22 2013]
Researchers at F. Hoffmann-La Roche Report New ... [Published Equities.com - May 22 2013]
Emerging Pharma at ChemOutsourcing 2013 in Reco... [Published BioPortfolio - May 21 2013]
Design, Synthesis, and Molecular Modeling of N... [Published Journal of Medicinal Chemistry - May 21 2013]
eFFECTOR Therapeutics Raises $45 Million Series A [Published PE Hub News - May 21 2013]
Chuck Norris and Gena Norris Named As MAX Inter... [Published FinanzNachrichten.de - May 21 2013]
Ignyta Announces Acquisition of Actagene Oncolo... [Published Business Wire - May 20 2013]
Core Refinement toward Permeable β-Secretase (B... [Published Journal of Medicinal Chemistry - May 20 2013]
eFFECTOR Therapeutics Raises $45 Million in Ser... [Published FinanzNachrichten.de - May 20 2013]
Eunice Kennedy Shriver National Institute of Ch... [Published Zecco - May 20 2013]
Discovery of Novel STAT3 Small Molecule Inhibi... [Published Journal of Medicinal Chemistry - May 16 2013]
Assistant / Associate / Full Professor in Pharm... [Published Molecular Systems Biology - May 16 2013]
Development and Therapeutic Implications of Se... [Published Journal of Medicinal Chemistry - May 15 2013]
How Exercise Alters Brain Chemistry [Published EHow.com - May 15 2013]
Fragment-Based Drug Discovery of 2-Thiazolidin... [Published Journal of Medicinal Chemistry - May 15 2013]
Pharmaceutical Breakfast Briefing: 21st May [Published Terrapinn - May 14 2013]
Coordinated TAKTIC [Published Drug Discovery News - May 13 2013]
Cyclica collaborates with Dalton Pharma Services [Published Drug Discovery News - May 13 2013]
ProQinase GmbH and Mercachem Holding B.V. Obtai... [Published BioSpace - May 13 2013]
ProQinase and Mercachem Obtain €2.5m EU Eurosta... [Published Pharma-Mag - May 13 2013]
Findings from Scripps Research Institute in Med... [Published NewsRX - May 11 2013]
Mobile Alliance for Maternal Action gives SA ma... [Published Lead SA - May 10 2013]
Why Not Share More Bioactivity Data? [Published In the Pipeline - May 10 2013]
Data from Institute for Research in Biomedicine... [Published NewsRX - May 10 2013]

Blogs

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ProQinase and Mercachem Obtain €2.5m EU Eurosta... [Published Pharma-Mag - May 13 2013] ProQinase and Mercachem received a €2.5m grant from the EU’s Eurostars program to support their joint efforts in establishing and expanding an innovative, small molecule drug discovery platform. The platform will comprise novel biological and pharmacological ...
Why Not Share More Bioactivity Data? [Published In the Pipeline - May 10 2013] The ChEMBL database of compoundshas been including bioactivity data for some time, and the next version of it is slated to have even more. There are a lot of numbers out in the open literature that can be collected, and a lot of numbers inside academic ...
Travel (University of Wisconsin) [Published In the Pipeline - Apr 30 2013] I'm in Madison, Wisconsin, where I'll be giving the Organic Chemistry McElvain Seminar later on today. The title of my talk, which I'm not sure if I'll live up to or not, is "Medicinal Chemistry: Getting Old, Or Just Starting to Grow Up?". It's at 3:30 ...
Dalton obtains notice of award form NIDA for re... [Published PBR - News - Mar 28 2013] Dalton Medicinal Chemistry has obtained a notice of award to fund research from The National Institute On Drug Abuse (NIDA) of the National Institutes of Health (NIH). ...
Putting the (Hard) Chemistry Back in Med Chem [Published In the Pipeline - Mar 04 2013] While I'm on the subject of editorials, Takashi Tsukomoto of Johns Hopkins has one out in ACS Medicinal Chemistry Letters . Part of it is a follow-up to my own trumpet call in the journal last year (check the top of the charts here ; the royalties ...

Press Releases

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Ignyta Announces Acquisition of Actagene Oncolo... [Published Business Wire - May 20 2013]
University of Minnesota Educator and Scientist ... [Published Business Wire - Apr 23 2013]
Reaxys® Medicinal Chemistry Provided as Part of... [Published PR Newswire: Entertainment & Media - Feb 04 2013]
Research and Markets: Neurodegenerative Disease... [Published Business Wire Health News - Dec 20 2012]