Molecular Probes

Type: Keyphrase
Name: Molecular Probes
First reported 22 hours ago - Updated 22 hours ago - 1 reports

Polymerase I and Transcript Release Factor Acts As an Essential Modulator of Glioblastoma Chemoresistance

This study is to investigate if polymerase I and transcript release factor (PTRF) acts as a modulator in glioblastoma (GBM) chemoresistance.MethodsMultidrug resistant (MDR) GBM cell line U251AR was established by exposing the U251 cell line to imatinib. ... [Published PLoS medicine - 22 hours ago]
First reported Apr 14 2014 - Updated Apr 14 2014 - 1 reports

Plasminogen Deficiency Causes Reduced Corticospinal Axonal Plasticity and Functional Recovery after Stroke in Mice

Tissue plasminogen activator (tPA) has been implicated in neurite outgrowth and neurological recovery post stroke. tPA converts the zymogen plasminogen (Plg) into plasmin. In this study, using plasminogen knockout (Plg-/-) mice and their Plg-native littermates ... [Published PLoS medicine - Apr 14 2014]
Entities: Neuron, Axon, Fibrinolysin
First reported Apr 13 2014 - Updated Apr 13 2014 - 1 reports

WISP-1 Contributes to Fractionated Irradiation-Induced Radioresistance in Esophageal Carcinoma Cell Lines and Mice

Cancer cells that survive fractionated irradiation can be radioresistant and cause tumor recurrence. However, the molecular mechanisms underlying the development of radioresistance in cancer cells remain elusive. The aim of this study was to investigate ... [Published PLoS medicine - Apr 13 2014]
First reported Apr 10 2014 - Updated Apr 10 2014 - 1 reports

ABBOTT LABORATORIES : Patent Application Titled "Double Stranded Linear Nucleic Acid Probe" Published Online

By a News Reporter-Staff News Editor at AIDS Weekly -- According to news reporting originating from Washington, D.C. , by NewsRx journalists, a patent application by the inventors Abravaya, Klara X. ( Kenilworth, IL ); Hackett, John R. ( Libertyville, ... [Published 4 Traders - Apr 10 2014]
First reported Mar 23 2014 - Updated Mar 23 2014 - 1 reports

Underlying Mechanism of Antimicrobial Activity of Chitosan Microparticles and Implications for the Treatment of Infectious Diseases

The emergence of antibiotic resistant microorganisms is a great public health concern and has triggered an urgent need to develop alternative antibiotics. Chitosan microparticles (CM), derived from chitosan, have been shown to reduce E. coli O157:H7 shedding ... [Published PLoS medicine - Mar 23 2014]
First reported Mar 19 2014 - Updated Mar 19 2014 - 1 reports

Strong Static Magnetic Fields Elicit Swimming Behaviors Consistent with Direct Vestibular Stimulation in Adult Zebrafish

Zebrafish (Danio rerio) offer advantages as model animals for studies of inner ear development, genetics and ototoxicity. However, traditional assessment of vestibular function in this species using the vestibulo-ocular reflex requires agar-immobilization ... [Published PLoS medicine - Mar 19 2014]
First reported Mar 19 2014 - Updated Mar 19 2014 - 1 reports

Ascl1 as a Novel Player in the Ptf1a Transcriptional Network for GABAergic Cell Specification in the Retina

In contrast with the wealth of data involving bHLH and homeodomain transcription factors in retinal cell type determination, the molecular bases underlying neurotransmitter subtype specification is far less understood. Using both gain and loss of function ... [Published PLoS medicine - Mar 19 2014]
Entities: Embryo, Neuron, ectopic
First reported Mar 14 2014 - Updated Mar 14 2014 - 1 reports

Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8

Signaling via heterotrimeric G-protein is involved in the development of human diseases including ischemia-reperfusion injury of the heart. We previously identified an ischemia-inducible G-protein activator, activator of G-protein signaling 8 (AGS8), ... [Published PLoS medicine - Mar 14 2014]
First reported Mar 12 2014 - Updated Mar 12 2014 - 1 reports

Rosamines Targeting the Cancer Oxidative Phosphorylation Pathway

IntroductionConventional cancer chemotherapy depends on drugs that act by interrupting DNA replication, i.e. by inhibiting the synthesis or function of new nucleic materials, or by causing irreparable damage to vital nucleic acids through intercalation, ... [Published PLoS medicine - Mar 12 2014]
First reported Mar 12 2014 - Updated Mar 12 2014 - 1 reports

Neonatal Peripheral Immune Challenge Activates Microglia and Inhibits Neurogenesis in the Developing Murine Hippocampus

The early postnatal period represents an important window in rodent hippocampal development with peak hilar neurogenesis and widespread microgliogenesis occurring in the first week of life. Inflammation occurring during this period may negatively influence ... [Published Sexual Development - Mar 12 2014]
First reported Mar 12 2014 - Updated Mar 12 2014 - 1 reports

Cyclic Strain-Induced Cytoskeletal Rearrangement of Human Periodontal Ligament Cells via the Rho Signaling Pathway

Although mechanical stimulations are known have a significant impact on cytoskeletal rearrangement, little is known regarding the behavioral alteration of human periodontal ligament cells (hPDLCs) under cyclic strain. The aim of this study was to elucidate ... [Published PLoS medicine - Mar 12 2014]
First reported Mar 10 2014 - Updated Mar 11 2014 - 3 reports

Scientists invent a pair of high-tech glasses that help surgeons visualize cancer cells during surgeries

A team of scientists at Washington University School of Medicine in St. Louis (WUSTL) and the University of Arizona (UA) in Tucson led by Samuel Achilefu have created a pair of high-tech glasses that help surgeons visualize cancer cells during surgeries, ... [Published News-Medical.Net - Mar 11 2014]
Entities: Cancer, Surgeon, Spie

Quotes

"One preferred amplification format is known as a real-time homogeneous assay. A real-time assay is one that produces data indicative of the presence or quantity of a target molecule during the amplification process, as opposed to the end of the amplification process. A homogeneous assay is one in which the amplification and detection reagents are mixed together and simultaneously contacted with a sample, which may contain a target nucleic acid molecule. Thus, the ability to detect and quantify DNA targets in real-time homogeneous systems as amplification proceeds is centered in single-tube assays in which the processes required for target molecule amplification and detection take place in a single 'close-tube' reaction format. For example, current techniques that use PCR amplification and have these features are generally known as Real-Time PCR techniques. Similarly, non-PCR-based technologies are also within the skill of the ordinary artisan and are amenable to homogeneous detection methods."

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Polymerase I and Transcript Release Factor Acts... [Published PLoS medicine - 22 hours ago]
Plasminogen Deficiency Causes Reduced Corticosp... [Published PLoS medicine - Apr 14 2014]
WISP-1 Contributes to Fractionated Irradiation-... [Published PLoS medicine - Apr 13 2014]
ABBOTT LABORATORIES : Patent Application Titled... [Published 4 Traders - Apr 10 2014]
Underlying Mechanism of Antimicrobial Activity ... [Published PLoS medicine - Mar 23 2014]
Combination Therapy Accelerates Diabetic Wound ... [Published PLoS medicine - Mar 20 2014]
Roles of Autophagy in MPP+-Induced Neurotoxicit... [Published PLoS medicine - Mar 19 2014]
Strong Static Magnetic Fields Elicit Swimming B... [Published PLoS medicine - Mar 19 2014]
Ascl1 as a Novel Player in the Ptf1a Transcript... [Published PLoS medicine - Mar 19 2014]
Anti-Scarring Properties of Different Tryptopha... [Published PLoS medicine - Mar 18 2014]
Long Term Expansion of Bone Marrow-Derived hMSC... [Published PLoS medicine - Mar 18 2014]
Palmitoyl Acyltransferase, Zdhhc13, Facilitates... [Published PLoS medicine - Mar 18 2014]
Monocyte Chemoattractant Protein-1 (MCP-1) Regu... [Published PLoS medicine - Mar 14 2014]
Protection of Cardiomyocytes from the Hypoxia-M... [Published PLoS medicine - Mar 14 2014]
Structural Bases of Norovirus RNA Dependent RNA... [Published PLoS medicine - Mar 12 2014]
The Involvement of Proteoglycans in the Human P... [Published PLoS medicine - Mar 12 2014]
Mitochondrial-Targeted Curcuminoids: A Strategy... [Published PLoS medicine - Mar 12 2014]
Rosamines Targeting the Cancer Oxidative Phosph... [Published PLoS medicine - Mar 12 2014]
Neonatal Peripheral Immune Challenge Activates ... [Published Sexual Development - Mar 12 2014]
Cyclic Strain-Induced Cytoskeletal Rearrangemen... [Published PLoS medicine - Mar 12 2014]
Epigenetic Silencing of Apoptosis-Inducing Gene... [Published PLoS medicine - Mar 11 2014]
Scientists invent a pair of high-tech glasses t... [Published News-Medical.Net - Mar 11 2014]
Samuel Achilefu, WUSTL scientists develop high-... [Published Brightsurf Science News - Mar 10 2014]
New high-tech glasses detect cancer cells durin... [Published Bio-Medicine - Mar 10 2014]
Detection of molecular interactions using a red... [Published PharmCast - Oct 09 2013]
Detection of disease related genes [Published PharmCast - Oct 04 2013]
Epic Sciences Announces Appointment of Dr. Mura... [Published PR Newswire - Aug 22 2013]
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Epic Sciences Announces Appointment of Dr. Mura... [Published PR Newswire - Aug 22 2013]
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