MPTP

Type: Keyphrase

Name: MPTP

First reported Apr 19 2013 - Updated Apr 19 2013 - 1 reports

Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

by Daniel Alvarez-Fischer, Carmen Noelker, Franca Vulinović, Anne Grünewald, Caroline Chevarin, Christine Klein, Wolfgang H. Oertel, Etienne C. Hirsch, Patrick P. Michel, Andreas HartmannBee venom has recently been suggested to possess beneficial effects ... [Published Elites TV - Apr 19 2013]

Entities: Neuroprotective Agents, Parkinson's Disease, MPTP, Neuron

First reported Jan 21 2013 - Updated Jan 22 2013 - 1 reports

Hope for Parkinson's Tx

share this storyResearchers have found a possible way to mitigate some of the symptoms of Parkinson's Disease, a brain disorder that affects as many as one million Americans, the majority of whom are over 50. Narayan G. Avadhani and colleagues at the ... [Published ThirdAge - Jan 21 2013]

Entities: Contaminant, Parkinson's Disease, MPTP

Quotes

...in several validated preclinical mouse models of dystonia are very compelling," stated Graham Dixon, Ph D , Chief Scientific Officer at Addex. "These preclinical data as well as our findings in the Phase 2a clinical trial measuring levodopa-induced dyskinesia in Parkinson's patients and the MPTP monkey model of Parkinson's disease suggest that an mGlu5 negative allosteric modulator may potentially be an effective therapeutic approach for the treatment of certain dystonias. We plan to initiate a Phase 2 trial in the first half of the year to explore this hypothesis."

Addex Dipraglurant Normalizes Striatal Cholinergic Dysfunction in a Validated Preclinical Model o ... [Published Presscontacts.com - Apr 18 2013]

"These results are pivotal for our pre-clinical Parkinson's program showing, as they do, that the hpSC-derived neuronal cells can potentially ameliorate the behavioral symptoms without triggering dyskinesias. This data forms the foundation of our discussions with the FDA as we move towards our IND in 2013" said Dr Ruslan Semechkin, principal Investigator of this study, head of R&D for International Stem Cell Corporation and Member of the American Academy...

ISCC announces positive stem cell data in Parkinson's disease [Published PharmaBiz - Mar 22 2013]

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Addex Dipraglurant Normalizes Striatal Choliner... [Published Presscontacts.com - Apr 18 2013]
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Addex Dipraglurant Normalizes Striatal Choliner... [Published Best Invest - Apr 18 2013]
Addex Dipraglurant Normalizes Striatal Choliner... [Published Zecco - Apr 18 2013]
ISCC announces positive stem cell data in Parki... [Published PharmaBiz - Mar 22 2013]
Hope for Parkinson's Tx [Published ThirdAge - Jan 21 2013]
Fact Sheet for Pattani United Liberation Organi... [Published Able2Act - Feb 26 2008]