Population Genetics

Type: Keyphrase
Name: Population Genetics
First reported Jun 25 2014 - Updated Jun 25 2014 - 1 reports

Fish Genes and Climate from Medieval to Modern Times

ReferenceOlafsdottir, G.A., Westfall, K.M., Edvardsson, R. and Palsson, S. 2014. Historical DNA reveals the demographic history of Atlantic cod (Gadus morhua) in medieval and early modern Iceland. Proceedings of the Royal Society B 281 : 10.1098/r ... [Published CO2 Science - Jun 25 2014]
First reported Jun 19 2014 - Updated Jun 19 2014 - 1 reports

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease

Supported by the Grand Opportunity (GO) Exome Sequencing Project (ESP), through which grants were provided by the NHLBI (RC2 HL-103010 [HeartGO], RC2 HL-102923 [LungGO], RC2 HL-102924 [Women's Health Initiative ESP], RC2 HL-102925 [BroadGO], and RC2 HL-102926 ... [Published New England Journal of Medicine - Jun 19 2014]
First reported Jun 16 2014 - Updated Jun 16 2014 - 1 reports

BRCA2 Gene Now Connected to Lung Cancer, Doubling a Smoker's Risk

New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations. An international consortium of scientists including investigators at the Institute for Cancer Research ... [Published Advance for Administrators of the Laboratory - Jun 16 2014]
First reported Jun 12 2014 - Updated Jun 12 2014 - 1 reports

Patent Issued for Method of Tagging Using a Split DBR

By a News Reporter-Staff News Editor at Journal of Technology -- According to news reporting originating from Alexandria, Virginia , by VerticalNews journalists, a patent by the inventors Casbon, James (Hinxton, GB); Brenner , Sydney (Ely, GB); Osborne, ... [Published HispanicBusiness.com - Jun 12 2014]
First reported Jun 06 2014 - Updated Jun 06 2014 - 1 reports

Breast cancer gene linked to lung cancer

About a quarter of smokers who have a defect in the BRCA2 gene, best known for increasing the risk of breast cancer, will develop lung cancer at some point in their lifetime, according to a study published in Nature Genetics on June 1.Researchers led ... [Published HealthImaging - Jun 06 2014]
First reported Jun 03 2014 - Updated Jun 03 2014 - 1 reports

Genetics of Epilepsy, Vol 213

The book chapters cover different aspects of epilepsy genetics, starting with the "classical" concept of epilepsies as ion channel disorders. The second part of the book gives credit to the fact that by now non-ion channel genes are recognized as equally ... [Published Research and Markets - Jun 03 2014]
First reported Jun 01 2014 - Updated Jun 02 2014 - 2 reports

BRCA2 gene now connected to lung cancer, doubling a smoker's risk

PUBLIC RELEASE DATE: 2-Jun-2014New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations. An international consortium of scientists including investigators at ... [Published EurekAlert! - Jun 02 2014]

Quotes

...8 times," said study leader Richard Houlston, professor of Molecular and Population Genetics at The Institute of Cancer Research (ICR). "Smokers in general have nearly a 15 per cent chance of developing lung cancer, far higher than in non-smokers. Our results show that some smokers with BRCA2 mutations are at an enormous risk of lung cancer - somewhere in the region of 25 per cent over their lifetime. Lung cancer claims more than a million lives a year worldwide and is by far the biggest cancer killer in the UK. We know that the single biggest thing we can do to reduce death rates is to persuade people not to smoke, and our new findings make plain that this is even more critical in people with an underlying genetic risk."
"In certain embodiments, aspects of the subject invention are drawn to methods of determining the number of starting polynucleotide molecules sequenced from multiple different samples. In certain embodiments, the method includes: (1) attaching an adapter to starting polynucleotide molecules in multiple different samples, where the adapter for each sample includes: a unique MID specific for the sample; and a degenerate base region (DBR) (e g., a DBR with at least one nucleotide base selected from: R, Y, S, W, K, M, B D H, V, N, and modified versions thereof); (2) pooling the multiple different adapter-attached samples to generate a pooled sample; (3) amplifying the adapter-attached polynucleotides in the pooled sample; (4) sequencing a plurality of the amplified adapter-attached polynucleotides, where the sequence of the MID, the DBR and at least a portion of the polynucleotide is obtained for each of the plurality of adapter-attached polynucleotides; and (5) determining the number of distinct DBR sequences present in the plurality of sequenced adapter-attached polynucleotides from each sample to determine or estimate the number of starting polynucleotides from each sample that were sequenced in the sequencing step."
"These findings indicate that around a quarter of smokers with a specific defect in their BRCA2 gene will develop lung cancer – a disease which is almost invariably fatal. All smokers are taking a considerable risk with their health, regardless of their genetic profile, but the odds are stacked even more heavily against those with this genetic defect who smoke."
"But we have shown that you cannot assume that raising HDL by any mechanism will help patients. Perhaps other mechanisms exist that can lower risk, but we will need to keep searching for them" Kathiresan added

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Fish Genes and Climate from Medieval to Modern ... [Published CO2 Science - Jun 25 2014]
Loss-of-Function Mutations in APOC3, Triglyceri... [Published New England Journal of Medicine - Jun 19 2014]
BRCA2 Gene Now Connected to Lung Cancer, Doubli... [Published Advance for Administrators of the Laboratory - Jun 16 2014]
Patent Issued for Method of Tagging Using a Spl... [Published HispanicBusiness.com - Jun 12 2014]
Breast cancer gene linked to lung cancer [Published HealthImaging - Jun 06 2014]
Genetics of Epilepsy, Vol 213 [Published Research and Markets - Jun 03 2014]
BRCA2 gene now connected to lung cancer, doubli... [Published EurekAlert! - Jun 02 2014]
Smokers with gene defect have one in four chanc... [Published Medical Xpress - Jun 01 2014]
Raising `good cholesterol` may not always cut h... [Published Topnews.in - May 17 2012]
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