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rapamycin

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Name: rapamycin

First reported 7 hours ago - Updated 7 hours ago - 1 reports

Calorie Restriction Slows Loss of Neurogenesis

Neural plasticity is the ability of the brain to remodel and adapt, and one of the necessary mechanisms supporting this process is neurogenesis , the creation of new neurons . The practice of calorie restriction has been shown to slow the age-related ... [Published Fight Aging! - 7 hours ago]

Entities: Calorie Restriction, Age-Related, Neuron, rapamycin

First reported 22 hours ago - Updated 22 hours ago - 1 reports

University of Texas Health Science Center at Houston

Sugar overload is dangerous for the heart

Too much sugar in a diet appears to a trigger for heart problems, according to new research. Certain types of glucose appear to have an adverse effect on heart muscle. A research finding indicates that a single small molecule found in sugar (a glucose ... [Published Digital Journal - 22 hours ago]

Entities: Sugar, Glucose, University of Texas Health Science Center at Ho...

First reported Jun 16 2013 - Updated Jun 17 2013 - 3 reports

How too much sugar harms the heart

Consuming a diet high in sugar and starch may not be just about weight watching. New research has uncovered how carbohydrates and sugar damage the heart to lead to congestive heart failure.Researchers at University of Texas found a protein can accumulate ... [Published EMax Health - Jun 16 2013]

Entities: Sugar, congestive heart failure, Metabolite, Carbohydrates, Glucose

First reported Jun 16 2013 - Updated Jun 16 2013 - 1 reports

Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice

Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months. The research, led by a team of scientists at the Buck Institute for ... [Published Biosingularity - Jun 16 2013]

Entities: Age-Related, Heart Disease, rapamycin

First reported Jun 15 2013 - Updated Jun 15 2013 - 3 reports

Sugar overload can cause heart damage

India June 15(IM):Eating too much sugar can set people down a pathway to heart failure. A single small molecule, the glucose metabolite glucose 6-phosphate (G6P), causes stress to the heart that changes the muscle proteins and induces poor pump function ... [Published Indian Mirror - Jun 15 2013]

Entities: University of Texas Health Science Center at Ho..., Sugar, congestive heart failure, Glucose

First reported Jun 14 2013 - Updated Jun 14 2013 - 1 reports

Radiation-Induced Esophagitis Exacerbated by Everolimus

Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin 2013;63:11-30.Murphy JD, Spalding AC, Somnay YR, Markwart S, Ray ME, Hamstra DA: Inhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature. Clin Cancer Res ... [Published Sexual Development - Jun 14 2013]

Entities: everolimus, esophagitis, Cancer, Dosage, Drugs

First reported Jun 13 2013 - Updated Jun 14 2013 - 1 reports

Drug Development: To Sue or Not to Sue?

Although it may not happen often, clinical trials can sometimes be halted by patent disputes, leading to costly delays in bringing new drugs to market. At last, the UK Government has decided to do something about this in a bid to make UK patent law more ... [Published Pharma-Mag - Jun 13 2013]

Entities: Drugs, Patent, Patent Infringement

First reported Jun 12 2013 - Updated Jun 12 2013 - 2 reports

Novato Research Team Goes Back to the Future to Fight Father…

Scientists will probably never win the battle against Father Time, but a group of Novato researchers may have just won an important skirmish.The Buck Institute for Research on Aging on Monday announced the results of a study it says offers hope to those ... [Published Novato Patch - Jun 12 2013]

Entities: Age-Related, rapamycin, Heart Disease

First reported Jun 10 2013 - Updated Jun 11 2013 - 5 reports

Rapamycin Improves Heart Function in Old Mice

Long term administration of rapamycin has been demonstrated to slow aging in mice , and here one aspect of that outcome is examined in more detail: Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function ... [Published Fight Aging! - Jun 11 2013]

Entities: rapamycin, Age-Related, Drugs, echocardiography

First reported Jun 04 2013 - Updated Jun 04 2013 - 1 reports

Notes from the 2013 AGE Meeting

The American Aging Association (AGE) held its 2013 meeting a few days ago. The program was a mix of old-school and irrelevant research such as the effects of specific foods on parameters of aging, nothing that's going to help us meaningfully extend ... [Published Fight Aging! - Jun 04 2013]

Entities: rapamycin, Human Growth Hormone, Anti-Aging, American Aging Association

First reported May 28 2013 - Updated May 28 2013 - 1 reports

Looking at the Commercial Development of Rapamycin

The standard script is being followed for drug development based on rapamycin , by the look of things. Rapamycin reliably extends life in mice , which is more than can be said for the last set of overhyped alleged longevity-enhancing drugs , but it's ... [Published Fight Aging! - May 28 2013]

Entities: rapamycin, Commercial Development Company Limited, Drugs, University of Texas Health Science Center

First reported May 23 2013 - Updated May 24 2013 - 3 reports

University Of Montreal Scientists Discover How Rapamycin Slows Cell Growth

University of Montreal researchers have discovered a novel molecular mechanism that can potentially slow the progression of some cancers and other diseases of abnormal growth. In the May 23 edition of the journal Cell, scientists from the University of ... [Published BioSpace - May 24 2013]

Entities: rapamycin, Cell Growth, University of Montreal

Quotes

...481. The company identified these prognostic imbalances as: "...age, platinum failure, CA-125 level, geography, tumor size, months since last platinum treatment, and ECOG as baseline factors." These imbalances, plus the small number FR (100%) patients in each arm (n=23 in vintafolide + PLD arm and n=15 in PLD arm), could lead to OS variation...

Why Endocyte's Small Molecule Drug Conjugates + Imaging Platform Is Undervalued [Published Seeking Alpha - Jun 18 2013]

...in too much glucose, it adds insult to injury," said Professor Heinrich Taegtmeyer from the University of Texas Health Science Center at Houston. "We propose that glucose metabolic changes precede and regulate functional (and possibly also structural) remodelling of the heart" the authors explained

High sugar consumption directly linked to heart failure, data suggests [Published Food Navigator - Jun 18 2013]

"These drugs have a potential for treatment and this has now cleared a path to future studies with patients" Taegtmeyer said. (MR-16.6)

Sugar overload may lead to heart damage [Published DDI News - Jun 16 2013]

"Treatment is difficult. Physicians can give diuretics to control the fluid, and beta-blockers and ACE inhibitors to lower the stress on the heart and allow it to pump more economically. But we still have these terrible statistics and no new treatment for the past 20 years."

Too Much Sugar Can Cause Heart Failure [Published MediLexicon - Jun 16 2013]

More Content

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Calorie Restriction Slows Loss of Neurogenesis [Published Fight Aging! - 7 hours ago]
Immunosenescence Does Not Abrogate Engraftment ... [Published Transplantation - 14 hours ago]
Exercise After Cancer Diagnosis: Time to Get Mo... [Published Cancernetwork.com - 16 hours ago]
Demethoxycurcumin Inhibits Energy Metabolic and... [Published Journal of Agricultural and Food Chemistry - 18 hours ago]
Sugar overload is dangerous for the heart [Published Digital Journal - 22 hours ago]
Why Endocyte's Small Molecule Drug Conjugates +... [Published Seeking Alpha - Jun 18 2013]
High sugar consumption directly linked to heart... [Published Food Navigator - Jun 18 2013]
Structure of the cohesin inhibitor Wapl [Biophy... [Published PNAS - Jun 18 2013]
Postmenopausal Hormone Receptor–Positive Advanc... [Published Cancernetwork.com - Jun 18 2013]
UTHealth Research: Sugar Overload Can Damage Heart [Published Nutrition Horizon - Jun 16 2013]
How too much sugar harms the heart [Published EMax Health - Jun 16 2013]
Lifespan-Extending Drug Given Late in Life Reve... [Published Biosingularity - Jun 16 2013]
Sugar Can Stress Out Your Heart [Published Red Orbit - Jun 16 2013]
Sugar overload may lead to heart damage [Published DDI News - Jun 16 2013]
Too Much Sugar Can Cause Heart Failure [Published MediLexicon - Jun 16 2013]
The Benefits of a Ketogenic Diet and its Role i... [Published Mercola - Jun 16 2013]
Sugar overload can cause heart damage [Published Indian Mirror - Jun 15 2013]
Sugar overload can cause heart damage: study [Published msn.co.in - Jun 15 2013]
Study: Too much sugar can lead to heart failure [Published Individual.com - Jun 15 2013]
Sugar overload can damage heart according to UT... [Published EurekAlert! - Jun 14 2013]
BOLERO-3: Everolimus tweaks trastuzumab-resista... [Published Oncology Report - Jun 14 2013]
1α,25-Dihydroxycholecalciferol (Vitamin D3) Ind... [Published Sexual Development - Jun 14 2013]
Radiation-Induced Esophagitis Exacerbated by Ev... [Published Sexual Development - Jun 14 2013]
Research and Markets: mTOR Signaling Pathway in... [Published Business Wire Professional Services News - Jun 14 2013]
Incidence and Risk of Treatment-Related Mortali... [Published Elites TV - Jun 14 2013]
mTOR Signaling Pathway in Oncology Drug Pipelin... [Published Individual.com - Jun 14 2013]
Drug Development: To Sue or Not to Sue? [Published Pharma-Mag - Jun 13 2013]
LAM Therapeutics Kicks Off Operations to Develo... [Published Individual.com - Jun 12 2013]
Novato Research Team Goes Back to the Future to... [Published Novato Patch - Jun 12 2013]
Old drug may help aging hearts [Published Individual.com - Jun 12 2013]

Blogs

sort by: Date \| Relevance
Calorie Restriction Slows Loss of Neurogenesis [Published Fight Aging! - 7 hours ago] Neural plasticity is the ability of the brain to remodel and adapt, and one of the necessary mechanisms supporting this process is neurogenesis , the creation of new neurons . The practice of calorie restriction has been shown to slow the age-related ...
Lifespan-Extending Drug Given Late in Life Reve... [Published Biosingularity - Jun 16 2013] Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months. The research, led by a team of scientists at the Buck Institute for ...
Drug Development: To Sue or Not to Sue? [Published Pharma-Mag - Jun 13 2013] Although it may not happen often, clinical trials can sometimes be halted by patent disputes, leading to costly delays in bringing new drugs to market. At last, the UK Government has decided to do something about this in a bid to make UK patent law more ...
Rapamycin Improves Heart Function in Old Mice [Published Fight Aging! - Jun 11 2013] Long term administration of rapamycin has been demonstrated to slow aging in mice , and here one aspect of that outcome is examined in more detail: Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function ...
Organ Transplant Drug Reverses Age-Related Hear... [Published Pharma-Mag - Jun 11 2013] The lifespan-extending properties – at least in mice – of the transplant rejection drug rapamycin have long been batted from journal to journal and commentary to commentary, but researchers at the Buck Institute for Age Research have published new work ...

Press Releases

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Research and Markets: mTOR Signaling Pathway in... [Published Business Wire Professional Services News - Jun 14 2013]