Ridaforolimus

Type: Product
Name: Ridaforolimus
First reported Aug 06 2014 - Updated Aug 06 2014 - 1 reports

Researchers' Work from Children's Hospital Focuses on Adverse Drug Reactions (A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and...

Researchers' Work from Children's Hospital Focuses on Adverse Drug Reactions (A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and pharmacodynamic study of ridaforolimus in patients with refractory solid tumors)By a News Reporter-Staff News ... [Published Pharmacy Choice - Aug 06 2014]
First reported Jul 28 2014 - Updated Jul 28 2014 - 1 reports

The PI3K/AKT/ mTOR Pathway in Breast Cancer

Andre, F., Campone, M., O'Regan, R., Manlius, C., Massacesi, C., Sahmoud, T. et al. (2010) Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 28: 5110 ... [Published General Medicine eJournal - Jul 28 2014]
First reported May 13 2014 - Updated May 13 2014 - 1 reports

IMPAKT Combination of mTOR and AKT inhibitors in patients with advanced breast cancer

A combination of mTOR inhibitor, ridaforolimus and novel AKT inhibitor, MK-2206, showed activity in heavily pretreated hormone positive and negative breast cancer patients who exhibit PI3K pathway dependence, based on low RAS signature score. The...Related ... [Published BioPortfolio - May 13 2014]
First reported Feb 28 2014 - Updated Feb 28 2014 - 1 reports

DOTW Keeps Tabs As Tax Trimming Fuels Deals

As an industry, biopharma actually fares pretty well when it comes to taxes. Among profitable companies, biotech and pharma have some of the lowest effective U.S. tax rates compared to companies in other sectors. But that doesn’t mean they have stopped ... [Published The IN VIVO Blog - Feb 28 2014]
First reported Feb 25 2014 - Updated Feb 25 2014 - 1 reports

Merck Abandons Once-Promising Experimental Cancer Drug to Ariad

Merck & Co. Inc.  ( NYSE:MRK ) has officially washed its hands of a once-lauded experimental cancer drug it invested in along with Ariad Pharmaceuticals Inc.  ( NASDAQ:ARIA ) Merck informed Ariad last week that it was terminating its license agreement ... [Published Wall St. Cheat Sheet - Feb 25 2014]

Quotes

...According to news originating from Aurora Colorado, by NewsRx correspondents, research stated, "Ridaforolimus (MK-8669, AP23573) is a potent and selective mammalian target of rapamycin (mTOR) inhibitor. Preclinically, ridaforolimus displays antiproliferative activity against a variety of human tumors in vitro and tumor xenograft models in vivo, with additive or synergistic activity when combined with other anticancer agents."
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Researchers' Work from Children's Hospital Focu... [Published Pharmacy Choice - Aug 06 2014]
The PI3K/AKT/ mTOR Pathway in Breast Cancer [Published General Medicine eJournal - Jul 28 2014]
IMPAKT Combination of mTOR and AKT inhibitors i... [Published BioPortfolio - May 13 2014]
DOTW Keeps Tabs As Tax Trimming Fuels Deals [Published The IN VIVO Blog - Feb 28 2014]
Merck Abandons Once-Promising Experimental Canc... [Published Wall St. Cheat Sheet - Feb 25 2014]
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sort by: Date | Relevance
DOTW Keeps Tabs As Tax Trimming Fuels Deals [Published The IN VIVO Blog - Feb 28 2014]
As an industry, biopharma actually fares pretty well when it comes to taxes. Among profitable companies, biotech and pharma have some of the lowest effective U.S. tax rates compared to companies in other sectors. But that doesn’t mean they have stopped ...
Merck Abandons Once-Promising Experimental Canc... [Published Wall St. Cheat Sheet - Feb 25 2014]
Merck & Co. Inc.  ( NYSE:MRK ) has officially washed its hands of a once-lauded experimental cancer drug it invested in along with Ariad Pharmaceuticals Inc.  ( NASDAQ:ARIA ) Merck informed Ariad last week that it was terminating its license agreement ...
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